Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders. [PDF]
Int J Mol Sci, 2022 Damage-associated molecular patterns (DAMPs) are endogenous danger molecules released from the extracellular and intracellular space of damaged tissue or dead cells. Recent evidence indicates that DAMPs are associated with the sterile inflammation caused by aging, increased ocular pressure, high glucose, oxidative stress, ischemia, mechanical trauma ...
Mahaling B +7 more
europepmc +5 more sources
Role of Damage-Associated Molecular Patterns (DAMPS) in the Postoperative Period after Colorectal Surgery. [PDF]
Int J Mol Sci, 2023 Anastomotic leakage (AL) is a defect of the intestinal wall at the anastomotic site and is one of the most severe complications in colorectal surgery. Previous studies have shown that the immune system response plays a significant role in the development of AL.
Caballero-Herrero MJ +4 more
europepmc +4 more sources
Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy. [PDF]
Mol BiomedAbstract Damage-associated molecular patterns (DAMPs) are endogenous danger signal molecules released by damaged, stressed or dead cells that bind to pattern recognition receptors (PRRs), activating immune responses and inflammatory signaling pathways to play critical regulatory roles in various pathophysiological processes.
Lin H, Xiong W, Fu L, Yi J, Yang J.
europepmc +5 more sources
Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases. [PDF]
Mitochondrion, 2018 Inflammation represents a comprehensive host response to external stimuli for the purpose of eliminating the offending agent, minimizing injury to host tissues and fostering repair of damaged tissues back to homeostatic levels. In normal physiologic context, inflammatory response culminates with the resolution of infection and tissue damage response ...
Dela Cruz CS, Kang MJ.
europepmc +5 more sources
Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation. [PDF]
Burns, 2017 Burns are associated with activation of the innate immunity that can contribute to complications. Damage-associated molecular patterns (DAMPs) released after tissue injury play a critical role in the activation of the innate immunity, which appears to be mediated via toll-like receptors (TLRs).
Rani M +3 more
europepmc +5 more sources
Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats. [PDF]
Brain Behav Immun, 2018 We have recently reported that a short course of morphine, starting 10days after sciatic chronic constriction injury (CCI), prolonged the duration of mechanical allodynia for months after morphine ceased. Maintenance of this morphine-induced persistent sensitization was dependent on spinal NOD-like receptor protein 3 (NLRP3) inflammasomes-protein ...
Grace PM +5 more
europepmc +6 more sources
Role of Damage-Associated Molecular Patterns (DAMPs/Alarmins) in Severe Ocular Allergic Diseases. [PDF]
Cells, 2022 Severe ocular allergic diseases, such as atopic keratoconjunctivitis and vernal keratoconjunctivitis, cause severe allergic inflammation in the conjunctiva and corneal epithelial damage, resulting in visual disturbances. The involvement of damage (danger)-associated molecular patterns (DAMPs/alarmins) in the pathogenesis of these diseases has been ...
Fukuda K +6 more
europepmc +4 more sources
Damage-associated molecular patterns (DAMPs) in vascular diseases. [PDF]
J Biol ChemResearch into the role of chronic sterile inflammation (i.e., a prolonged inflammatory state not caused by an infectious agent) in vascular disease progression has continued to grow over the last few decades. DAMPs have a critical role in this research due to their ability to link stress-causing cardiovascular risk factors to inflammatory phenotypes ...
Antonello J, Roy P.
europepmc +3 more sources
The Damage-Associated Molecular Patterns (DAMPs) as Potential Targets to Treat Osteoarthritis: Perspectives From a Review of the Literature. [PDF]
Front Med (Lausanne), 2020 During the osteoarthritis (OA) process, activation of immune systems, whether innate or adaptive, is strongly associated with low-grade systemic inflammation. This process is initiated and driven in the synovial membrane, especially by synovium cells, themselves previously activated by damage-associated molecular patterns (DAMPs) released during ...
Lambert C +5 more
europepmc +7 more sources
Old and new damage‐associated molecular patterns (DAMPs) in autoimmune diseases
Rheumatology & Autoimmunity, 2022 AbstractAll organisms living in complex environments have evolved effective mechanisms of dynamic responses to extracellular stimuli. The immune system activates when damaged or injured cells release damage‐associated molecular patterns (DAMPs). In addition to well‐characterized DAMPs such as high‐mobility group box 1 and adenosine triphosphate ...
Wanli Liu
exaly +3 more sources