Transplantation and Damage-Associated Molecular Patterns (DAMPs)
American Journal of Transplantation, 2016 Upon solid organ transplantation and during cancer immunotherapy, cellular stress responses result in the release of damage-associated molecular patterns (DAMPs). The various cellular stresses have been characterized in detail over the last decades, but a unifying classification based on clinically important aspects is lacking.
W Land +2 more
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Inflammatory and fibrotic responses of cardiac fibroblasts to myocardial damage associated molecular patterns (DAMPs) [PDF]
Journal of Molecular and Cellular Cardiology, 2016 Cardiac fibroblasts (CF) are well-established as key regulators of extracellular matrix (ECM) turnover in the context of myocardial remodelling and fibrosis. Recently, this cell type has also been shown to act as a sensor of myocardial damage by detecting and responding to damage-associated molecular patterns (DAMPs) upregulated with cardiac injury. CF
Neil A Turner
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Sequestering of damage-associated molecular patterns (DAMPs): a possible mechanism affecting the immune-stimulating properties of aluminium adjuvants. [PDF]
Immunol Res, 2017 Aluminium-based adjuvants (ABAs) have been used in human and veterinary vaccines for decades, and for a long time, the adjuvant properties were believed to be mediated by an antigen depot at the injection site, prolonging antigen exposure to the immune system.
Svensson A +3 more
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Untangling Local Pro-Inflammatory, Reparative, and Regulatory Damage-Associated Molecular-Patterns (DAMPs) Pathways to Improve Transplant Outcomes. [PDF]
Front Immunol, 2021 Dwyer GK, Turnquist HR.
europepmc +2 more sources
The Role of Damage-Associated Molecular Patterns (DAMPs) in Human Diseases: Part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine. [PDF]
Sultan Qaboos Univ Med J, 2015 This article is the second part of a review that addresses the role of damage-associated molecular patterns (DAMPs) in human diseases by presenting examples of traumatic (systemic inflammatory response syndrome), cardiovascular (myocardial infarction), metabolic (type 2 diabetes mellitus), neurodegenerative (Alzheimer's disease), malignant and ...
Land WG.
europepmc +5 more sources
FEBS Letters, 2011 An efficient sensing of danger and a rapid activation of the immune system are crucial for the survival of plants. Conserved pathogen/microbe‐associated molecular patterns (PAMPs/MAMPs) and endogenous molecular patterns, which are present only when the tissue is infected or damaged (damage‐associated molecular patterns or DAMPs), can act as danger ...
Giulia de Lorenzo +2 more
exaly +4 more sources
Diagnostic accuracy of damage-associated molecular patterns (DAMPs) in patients with heart failure with a reduced ejection fraction. [PDF]
J Clin Transl Sci, 2017 Hartupee J +6 more
europepmc +5 more sources
In silico selection of damage-associated molecular patterns (DAMPS) and their receptors in humans
Research, Society and Development, 2022 Damage-associated molecular patterns (DAMPs) are intracellular molecules released into the extracellular environment after injury. These are recognized by pattern recognition receptors (PRRs) and activate the innate immune system, triggering an inflammatory response.
Erika Aparecida Oliveira +6 more
openaire +2 more sources
Extracellular ATP acts as a damage-associated molecular pattern (DAMP) signal in plants [PDF]
Frontiers in Plant Science, 2014 As sessile organisms, plants have evolved effective mechanisms to protect themselves from environmental stresses. Damaged (i.e., wounded) plants recognize a variety of endogenous molecules as danger signals, referred to as damage-associated molecular patterns (DAMPs).
Tanaka, Kiwamu +3 more
openaire +4 more sources
Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors
Cells, 2022 Study of the initial steps of the CD95-mediated signaling pathways is a field of intense research and a long list of actors has been described in the literature. Nonetheless, the dynamism of protein-protein interactions (PPIs) occurring in the presence or absence of its natural ligand, CD95L, and the cellular distribution where these PPIs take place ...
Galli, Gael +4 more
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