Results 1 to 10 of about 44,760 (265)

Endogenous HMGB1 regulates autophagy [PDF]

Journal of Cell Biology, 2010
Autophagy clears long-lived proteins and dysfunctional organelles and generates substrates for adenosine triphosphate production during periods of starvation and other types of cellular stress. Here we show that high mobility group box 1 (HMGB1), a chromatin-associated nuclear protein and extracellular damage-associated molecular pattern molecule, is a
Daolin Tang, Marco Emilio Bianchi, Adam M Farkaš   +2 more
exaly   +3 more sources

HMGB1, anti-HMGB1 antibodies, and ratio of HMGB1/anti-HMGB1 antibodies as diagnosis indicator in fever of unknown origin [PDF]

Scientific Reports, 2021
AbstractTo evaluate the feasibility of serum HMGB1, anti-HMGB1 antibodies, and HMGB1/anti-HMGB1 ratio as a diagnosis indicator of initial clinical classification in patients with fever of unknown origin (FUO). Ninety-four patients with classical FUO and ninety healthy controls were enrolled in this study.
Mingkun Chen, Li Zhu, Miao Xue, Rongrong Zhu, Liling Jing, Huaizhou Wang, Yanghua Qin   +6 more
openaire   +3 more sources

Inflammatory signaling of HMGB1 in depressive disorder

Stress and Brain, 2023
Background:Depressive disorder is a common disease characterized by depressed mood and loss of pleasure, which often brings a great grief to patients and a huge burden to the society.
Qian Jiang, Chaoran Li, Huijing Xu, Taosheng Liu, Yunxia Wang   +4 more
doaj   +1 more source

HMGB1 in inflammation and cancer [PDF]

Journal of Hematology & Oncology, 2020
AbstractHigh mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability maintenance. In response to stimulus like bacteria or chemoradiotherapy, HMGB1 can translocate to extracellular context as a danger alarmin, activate the immune ...
Shumin Wang, Yi Zhang
openaire   +3 more sources

HMGB1: A pleiotropic activity [PDF]

Pediatric Allergy and Immunology, 2020
AbstractHigh‐mobility group box 1 (HMGB1) is a nuclear protein involved in DNA replication, transcription, recombination, and repair. In the extracellular space, the HMGB1 plays an essential role in the onset and perpetuation of inflammation, belonging to the group of damage‐associated molecular pattern (DAMP) molecules, also called alarmins. For this,
Colavita, Laura, Ciprandi, Giorgio, Salpietro, Annamaria, Cuppari, Caterina   +3 more
openaire   +2 more sources

β-catenin has potential effects on the expression, subcellular localization, and release of high mobility group box 1 during bovine herpesvirus 1 productive infection in MDBK cell culture

Virulence, 2021
High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, can be released into extracellular space and function as a strong proinflammatory cytokine, which plays critical roles in the pathogenesis of various inflammatory diseases.
Wenqing Fan, Weifeng Yuan, Xiuyan Ding, Liqian Zhu   +3 more
doaj   +1 more source

Can High Mobility Group Box 1 Protein Predict Ongoing Subclinical Inflammation in Patients With Familial Mediterranean Fever?

Journal of Behçet Uz Children's Hospital, 2023
Objective: Familial Mediterranean fever (FMF) is an autoinflammatory disease that commonly presents with fever, peritonitis, and pleuritis. Recent studies have reported ongoing inflammation in the attack-free period of patients with FMF.
Betül Öztürk, Esra Baskın, Kaan Gülleroğlu, Begüm Avcı, Nilüfer Bayraktar, Feride İffet Şahin   +5 more
doaj   +1 more source

Relationships between serum HMGB1 concentration and subpopulation composition of circulating monocytes in patients with subclinical atherosclerosis

Медицинская иммунология, 2022
Chronic non-infectious inflammation of low intensity is the most important mechanism of development and progression in atherosclerosis. Under the conditions of persistent non-resolving inflammation observed in the vascular wall and atherosclerotic plaque
V. V. Genkel, I. I. Dolgushin, I. L. Baturina, A. Yu. Savochkina, K. V. Nikushkina, A. A. Minasova, L. R. Pykhova, A. S. Kuznetcova, I. I. Shaposhnik   +8 more
doaj   +1 more source

Targeting HMGB1 in inflammation [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010
High mobility group box 1 (HMGB1), a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. Elevated levels of HMGB1 in serum and tissues occur during sterile tissue injury and during infection, and ...
Huan, Yang, Kevin J, Tracey
openaire   +2 more sources

HMGB1 release by inflammasomes [PDF]

Virulence, 2011
High-mobility group box 1 (HMGB1) was originally identified as a highly conserved nuclear DNA-binding protein that participates in DNA replication, repair and transcriptional regulation of gene expression. Although the nuclear role of HMGB1 is not quite understood, recent studies characterized the emerging role of extracellular HMGB1 as a prototypical ...
Lieselotte, Vande Walle, Thirumala-Dev, Kanneganti, Mohamed, Lamkanfi   +2 more
openaire   +2 more sources