Results 1 to 10 of about 51,717 (306)

HMGB1 SASP Cytokine Production.

, 2014
Bar graphs show cytokine concentrations in p38MAPK inhibitor SB203580, HMGB1 inhibitor (GA), and HMGB1treated, and simultaneous HMGB1 with SB203580 (30 uM), GA (100 uM), or a combination of both SB203580 and GA treated fetal membrane culture media.
Talar Kechichian (232438), Tariq A. Syed (668711), James H. Deford (668710), Sarah Bredeson (668709), George R. Saade (502573), Ramkumar Menon (201971), John Papaconstantinou (52191)   +6 more
core   +1 more source

HMGB1’in Kanser ve Tedavisiyle İlişkisi

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2019
Yüksek mobilite grup kutusu 1 (HMGB1)histon olmayan DNA proteini olup, kısaca DAMP olarak ifade edilen(Damage-associated molecular pattern) tehlike sinyali veya alarmı olarak görevyapar.
Celal Güven, Eylem Taşkın Güven, Salih Tunç Kaya, Yusuf Sevgiler   +3 more
doaj   +1 more source

HMGB1: Endogenous Danger Signaling

Molecular Medicine, 2008
While foreign pathogens and their products have long been known to activate the innate immune system, the recent recognition of a group of endogenous molecules that serve a similar function has provided a framework for understanding the overlap between the inflammatory responses activated by pathogens and injury.
Klune, John R, Dhupar, Rajeev, Cardinal, Jon, Billiar, Timothy R, Tsung, Allan   +4 more
openaire   +2 more sources

Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer [PDF]

, 2018
[Abstract] High Mobility Group B (HMGB) proteins are involved in cancer progression and in cellular responses to platinum compounds used in the chemotherapy of prostate and ovary cancer. Here we use affinity purification coupled to mass spectrometry (MS)
Esther Rodríguez-Belmonte, Yu, L, Aida Barreiro-Alonso, Barreiro-Alonso, A, Lamas, Mónica, Lamas-Maceiras, M, Rodríguez-Belmonte, E, Barreiro-Alonso, Aida, Cerdán, ME, Mónica Lamas-Maceiras, Rosa García-Díaz, Choudhary, Jyoti, Lu Yu, María Esperanza Cerdán, García-Díaz, R, Jyoti S. Choudhary, Rodríguez-Belmonte, Esther, Pardo, M, García-Díaz, Rosa, Yu, Lu, Cerdán, María Esperanza, Mercedes Pardo, Choudhary, JS, Pardo, Mercedes   +23 more
core   +1 more source

Exploring the Neuroinflammatory Pathway in Epilepsy and Cognitive Impairment: Role of HMGB1 and Translational Challenges

Frontiers in Bioscience-Landmark
Neuroinflammation has emerged as a shared molecular mechanism in epilepsy and cognitive impairment, offering new insights into the complex interplay between immune responses and brain function.
Irma Wati Ngadimon, Eryse Amira Seth, Mohd. Farooq Shaikh   +2 more
doaj   +1 more source

HMGB1: a signal of necrosis.

Autoimmunity, 2007
When tissues are damaged, they usually heal. The cellular responses towards healing require the prior recognition that damage has occurred. High Mobility Group Box 1 protein (HMGB1) is a ubiquitous nuclear protein that is passively released by cells that have died in a traumatic, non-programmed way (necrosis).
RAUCCI A, PALUMBO R, BIANCHI , MARCO EMILIO   +2 more
openaire   +2 more sources

Fingolimod Alleviates Inflammation after Cerebral Ischemia via HMGB1/TLR4/NF-κB Signaling Pathway

Journal of Integrative Neuroscience
Background: Clinically, ischemic reperfusion injury is the main cause of stroke injury. This study aimed to assess the effectiveness of fingolimod in suppressing inflammation caused by ischemic brain injury and explore its pharmacological mechanisms ...
Yao Xing, Liyuan Zhong, Jun Guo, Cuifen Bao, Yumin Luo, Lianqiu Min   +5 more
doaj   +1 more source

miR- 26a Sensitizes Melanoma Cells To Dabrafenib Via Targeting HMGB1-Dependent Autophagy Pathways

Drug Design, Development and Therapy, 2019
Yan Yu,1,* Niu Xiang,2,* Min Lin,2 Jin-Wen Huang,2 Jing Zhang,2 Bo Cheng,2 Chao Ji2 1Department of Dermatology, First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China; 2Department of Dermatology, The First ...
Yu Y, Xiang N, Lin M, Huang JW, Zhang J, Cheng B, Ji C   +6 more
doaj  

A Preliminary Finding: N-butyl-phthalide Plays a Neuroprotective Role by Blocking the TLR4/HMGB1 Pathway and Improves Mild Cognitive Impairment Induced by Acute Cerebral Infarction

Journal of Integrative Neuroscience
Background: Most acute cerebral infarctions (ACI) may develop vascular dementia (VD), which involves almost all types of cognitive impairment. Unfortunately, there is currently no effective treatment for VD.
Hong Zhou, Sijun Li, Cheng Huang, Yingping Chen, Liwen Wang, Junliang Lin, Yuan Lv   +6 more
doaj   +1 more source

DataSheet1_Pharmacological Inhibition of HMGB1 Prevents Muscle Wasting.pdf

, 2021
Background: Cachexia is a multifactorial disorder characterized by weight loss and muscle wasting, making up for about 20% of cancer-related death. However, there are no effective drugs to combat cachexia at present.Methods: In this study, the effect of ...
Su Wen (95583), Huiquan Liu (147143), Shiying Yu (762728), Xiaofen Fu (4642165), Weili Tao (10772154), Lu Li (14069)   +5 more
core   +1 more source