Results 11 to 20 of about 44,760 (265)

The cytokine activity of HMGB1 [PDF]

Journal of Leukocyte Biology, 2005
AbstractHigh mobility group box 1 (HMGB1) is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types. We recently discovered that HMGB1 is secreted into the extracellular milieu and acts as a proinflammatory cytokine.
Huan, Yang, Haichao, Wang, Christopher J, Czura, Kevin J, Tracey   +3 more
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HMGB1 in health and disease [PDF]

Molecular Aspects of Medicine, 2014
Complex genetic and physiological variations as well as environmental factors that drive emergence of chromosomal instability, development of unscheduled cell death, skewed differentiation, and altered metabolism are central to the pathogenesis of human diseases and disorders.
Rui, Kang, Ruochan, Chen, Qiuhong, Zhang, Wen, Hou, Sha, Wu, Lizhi, Cao, Jin, Huang, Yan, Yu, Xue-Gong, Fan, Zhengwen, Yan, Xiaofang, Sun, Haichao, Wang, Qingde, Wang, Allan, Tsung, Timothy R, Billiar, Herbert J, Zeh, Michael T, Lotze, Daolin, Tang   +17 more
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The mechanism of HMGB1 secretion and release [PDF]

Experimental & Molecular Medicine, 2022
AbstractHigh mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone that maintains the structure and function of chromosomes. In the cytoplasm, HMGB1 can promote autophagy by binding to BECN1 protein.
Chen, Ruochan, Kang, Rui, Tang, Daolin
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Editorial: The Role of HMGB1 in Immunity [PDF]

Frontiers in Immunology, 2020
open
Myoungsun Son, Myoungsun Son, Betty Diamond, Betty Diamond, Jeon-Soo Shin, Jeon-Soo Shin, Jeon-Soo Shin   +6 more
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Integrative Atherosclerosis Treatment: Harnessing Herbal and Synthetic HMGB1 Inhibitors [PDF]

Research Journal of Pharmacognosy
Human group box protein 1 (HMGB1) is a nuclear protein critical in various cellular processes. It is released in response to stress, infection, or tissue damage and acts as a danger signal, triggering immunological responses.
Ceaser Wankumbu Silumbwe*, Xiaoman Ji, Wang Jin, Chernor Sulaiman Bah, Julius Mulumba, Lukundo Siame, Ming Xu   +6 more
doaj   +1 more source

Electroacupuncture inhibits the expression of HMGB1/RAGE and alleviates injury to the primary motor cortex in rats with cerebral ischemia

Translational Neuroscience, 2023
The high-mobility group box 1 (HMGB1)/receptor for advanced glycation end products (RAGE) signaling pathway holds promise as a potential therapeutic target for ischemic brain injury. The effects of FPS-ZM1 and electroacupuncture (EA) on activation of the
Nie Zeyin, Miao Huachun, Li Chenyu, Wu Feng   +3 more
doaj   +1 more source

The Effect of PD-1 Inhibitor Combined with Irradiation on HMGB1-Associated Inflammatory Cytokines and Myocardial Injury

Journal of Inflammation Research, 2022
Jie Bai,1– 3,* Bibo Wu,1– 3,* Shasha Zhao,1– 3,* Gang Wang,1– 3,* Shengfa Su,1– 3 Bing Lu,1– 3 Yinxiang Hu,1– 3 Yichao Geng,1,3 Zhengneng Guo,1– 3 Jun Wan,2,3 Weiwei OuYang,1– 3 Cheng Hu,1– 3 Jie Liu1– 3 1Department of Oncology, The ...
Bai J, Wu B, Zhao S, Wang G, Su S, Lu B, Hu Y, Geng Y, Guo Z, Wan J, OuYang W, Hu C, Liu J   +12 more
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HMGB1 loves company [PDF]

Journal of Leukocyte Biology, 2009
Abstract HMGB1 outside of a cell is both a trigger of inflammation and a stimulus for tissue reconstruction; the balance may depend on the complexes it forms with other molecules. HMGB1, outside of a cell, is a trigger of inflammation and a stimulus for tissue reconstruction; the balance may depend on the complexes it ...
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MicroRNA-98 inhibition accelerates the development of atherosclerosis via regulation of dysfunction of endothelial cell

Clinical and Experimental Hypertension, 2023
Background Atherosclerosis has been recognized as a chronic inflammation initiated by dysfunction of endothelial cell that contributes to the increased morbidity and mortality of severe cardiovascular events.
Huai Yu, Hui Cao, Hang Yu
doaj   +1 more source

The Role of HMGB1 in Rheumatic Diseases [PDF]

Frontiers in Immunology, 2022
HMGB1, a highly conserved non-histone nuclear protein, is widely expressed in mammalian cells. HMGB1 in the nucleus binds to the deoxyribonucleic acid (DNA) to regulate the structure of chromosomes and maintain the transcription, replication, DNA repair, and nucleosome assembly.
Yuanji Dong, Bingxia Ming, Lingli Dong
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