Results 11 to 20 of about 56,183 (304)
HMGB1 release by inflammasomes [PDF]
Virulence, 2011 High-mobility group box 1 (HMGB1) was originally identified as a highly conserved nuclear DNA-binding protein that participates in DNA replication, repair and transcriptional regulation of gene expression. Although the nuclear role of HMGB1 is not quite understood, recent studies characterized the emerging role of extracellular HMGB1 as a prototypical ...
Lieselotte, Vande Walle +2 more
openaire +3 more sources
Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation [PDF]
Molecular Medicine, 2019 Extracellular high mobility group box 1 protein (HMGB1) serves a central role in inflammation as a transporter protein, which binds other immune-activating molecules that are endocytosed via the receptor for advanced glycation end-products (RAGE). These pro-inflammatory complexes are targeted to the endolysosomal compartment, where HMGB1 permeabilizes
Huan Yang +12 more
openaire +5 more sources
HMGB1 redox during sepsis [PDF]
Redox Biology, 2017 During sepsis, the alarmin HMGB1 is released from tissues and promotes systemic inflammation that results in multi-organ damage, with the kidney particularly susceptible to injury. The severity of inflammation and pro-damage signaling mediated by HMGB1 appears to be dependent on the alarmin's redox state.
Wasan Abdulmahdi +7 more
openaire +4 more sources
HMGB1, anti-HMGB1 antibodies, and ratio of HMGB1/anti-HMGB1 antibodies as diagnosis indicator in fever of unknown origin [PDF]
Scientific Reports, 2021 AbstractTo evaluate the feasibility of serum HMGB1, anti-HMGB1 antibodies, and HMGB1/anti-HMGB1 ratio as a diagnosis indicator of initial clinical classification in patients with fever of unknown origin (FUO). Ninety-four patients with classical FUO and ninety healthy controls were enrolled in this study.
Mingkun Chen +6 more
openaire +3 more sources
HMGB1 related pathways in epilepsy [PDF]
, 2022 Epilepsy is one of the most common neurological illnesses, affecting an estimated 70 million individuals worldwide. A mechanistic approach to discovering crucial pathogenic brain abnormalities driving seizure onset, recurrence, and advancement is ...
Önal, C. +3 more
core +2 more sources
HMGB1: Functions, inhibitors and clinical significance [PDF]
, 2022 Damage-associated molecular patterns (DAMPs), a term also known as alarmins coined by Walter G. Land, Seong, and Matzinger, are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting
Taşkın, E. +2 more
core +1 more source
Inflammatory signaling of HMGB1 in depressive disorder
Stress and Brain, 2023 Background:Depressive disorder is a common disease characterized by depressed mood and loss of pleasure, which often brings a great grief to patients and a huge burden to the society.
Qian Jiang +4 more
doaj +1 more source
HMGB1 in inflammation and cancer [PDF]
Journal of Hematology & Oncology, 2020 AbstractHigh mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability maintenance. In response to stimulus like bacteria or chemoradiotherapy, HMGB1 can translocate to extracellular context as a danger alarmin, activate the immune ...
Shumin Wang, Yi Zhang
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HMGB1: A pleiotropic activity [PDF]
Pediatric Allergy and Immunology, 2020 AbstractHigh‐mobility group box 1 (HMGB1) is a nuclear protein involved in DNA replication, transcription, recombination, and repair. In the extracellular space, the HMGB1 plays an essential role in the onset and perpetuation of inflammation, belonging to the group of damage‐associated molecular pattern (DAMP) molecules, also called alarmins. For this,
Colavita, Laura +3 more
openaire +2 more sources
The role of ferroptotic cell death-related HMGB1 in inflammation crosstalk with cancer and myocardial Ischemia/reperfusion injury [PDF]
, 2022 Inflammation is one of the critical defense pathways against pathogen and pathologic conditions, including cancer and myocardial ischemia/ reperfusion (MIR) injury. Therefore, inflammation has positive and negative impacts on tissues and organs.
Taşkın, E. +2 more
core +3 more sources