Results 11 to 20 of about 51,717 (306)

Endogenous HMGB1 regulates autophagy [PDF]

Journal of Cell Biology, 2010
Autophagy clears long-lived proteins and dysfunctional organelles and generates substrates for adenosine triphosphate production during periods of starvation and other types of cellular stress.
Daolin Tang, Rui Kang, Kristen M Livesey   +2 more
exaly   +4 more sources

HMGB1 release by inflammasomes [PDF]

Virulence, 2011
High-mobility group box 1 (HMGB1) was originally identified as a highly conserved nuclear DNA-binding protein that participates in DNA replication, repair and transcriptional regulation of gene expression.
Thirumala-Dev Kanneganti, Kanneganti, Thirumala-Devi, Vande Walle, Lieselotte, Mohamed Lamkanfi, Vande Walle, LieselotteGE350019973966178010018125430009-0001-3953-936722109836-F0EE-11E1-A9DE-61C894A0A6B4, Lieselotte Vande Walle, Lamkanfi, MohamedGE350019960063828010015031530000-0002-6350-72691E5D1DC2-F0EE-11E1-A9DE-61C894A0A6B4, Lamkanfi, Mohamed   +7 more
core   +3 more sources

Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation [PDF]

Molecular Medicine, 2019
Background Extracellular high mobility group box 1 protein  (HMGB1) serves a central role in inflammation as a transporter protein, which binds other immune-activating molecules that are endocytosed via the receptor for advanced glycation end-products ...
Huan Yang, Kai Fan Cheng, Tracey, K. J., Mingzhu He, Yang, H., Zeng, Q., Yousef Al-Abed, +3 additional authors, Hui Liu, Addorisio, M. E., Imperato, G. H., Gavin H. Imperato, Sangeeta S. Chavan, Meghan E. Addorisio, He, M., Jianhua Li, Ulf Andersson, Liu, H., Al-Abed, Y., Qiong Zeng, Cheng, K. F., Helena E. Harris, Chavan, S. S., Kevin J. Tracey   +23 more
core   +4 more sources

Editorial: The Role of HMGB1 in Immunity [PDF]

Frontiers in Immunology, 2020
High mobility group box 1 (HMGB1) is an evolutionarily conserved nuclear protein that can be released by almost all cell types. Scientists have uncovered a variety of molecular mechanisms by which HMGB1 in both immune and non-immune cells modulates the ...
Jeon-Soo Shin, Son, M., Betty Diamond, Shin, J., Myoungsun Son, Diamond, B.   +5 more
core   +5 more sources

Targeting Inflammation Driven by HMGB1

Frontiers in Immunology, 2020
© Copyright © 2020 Yang, Wang and Andersson. High mobility group box 1 (HMGB1) is a highly conserved, nuclear protein present in all cell types. It is a multi-facet protein exerting functions both inside and outside of cells. Extracellular HMGB1 has been
Huan Yang, Haichao Wang, Ulf Andersson   +2 more
exaly   +3 more sources

HMGB1 redox during sepsis

Redox Biology, 2017
During sepsis, the alarmin HMGB1 is released from tissues and promotes systemic inflammation that results in multi-organ damage, with the kidney particularly susceptible to injury.
Rameen Hashemiyoon, Edson Jules, Tala Azar, Lipphardt, Mark, Abdulmahdi, Wasan, Wasan Abdulmahdi, Patel, Devika, Rabadi, May, Mark Lipphardt, Ratliff, Brian B, May M. Rabadi, Devika Patel, Azar, Tala, Jules, Edson, Brian B. Ratliff, Hashemiyoon, Rameen   +15 more
core   +4 more sources

HMGB1: Functions, inhibitors and clinical significance [PDF]

, 2022
Damage-associated molecular patterns (DAMPs), a term also known as alarmins coined by Walter G. Land, Seong, and Matzinger, are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting
Taşkın, E., Kaya, Salih Tunç, Güven, Celal   +2 more
core   +3 more sources

HMGB1, anti-HMGB1 antibodies, and ratio of HMGB1/anti-HMGB1 antibodies as diagnosis indicator in fever of unknown origin [PDF]

Scientific Reports, 2021
AbstractTo evaluate the feasibility of serum HMGB1, anti-HMGB1 antibodies, and HMGB1/anti-HMGB1 ratio as a diagnosis indicator of initial clinical classification in patients with fever of unknown origin (FUO). Ninety-four patients with classical FUO and ninety healthy controls were enrolled in this study.
Mingkun Chen, Li Zhu, Miao Xue, Rongrong Zhu, Liling Jing, Huaizhou Wang, Yanghua Qin   +6 more
openaire   +3 more sources

Serum HMGB1 in febrile seizures [PDF]

Epilepsy Research
The role of high-mobility group box 1 (HMGB1) in the pathogenesis of febrile seizures (FSs) is unclear. In our controlled follow-up study, we compared serum levels of HMGB1 (s-HMGB1) in the same individuals after the first FS, during febrile episodes ...
Hautala, Maria K, Koskela, Ulla V, Rannikko, Sirpa K, Uhari, Matti K, Uhari, Matti K., Helander, Heli M., Hautala, Maria K., Rannikko, Sirpa K., Pokka, Tytti M.L., Koskela, Ulla V., Helander, Heli M, Mikkonen, Kirsi H., Glumoff, Virpi, Rantala, Heikki M.J., Mikkonen, Kirsi H, Pokka, Tytti M L, Rantala, Heikki M J   +16 more
core   +4 more sources

Inflammatory signaling of HMGB1 in depressive disorder

Stress and Brain, 2023
Background:Depressive disorder is a common disease characterized by depressed mood and loss of pleasure, which often brings a great grief to patients and a huge burden to the society.
Qian Jiang, Chaoran Li, Huijing Xu, Taosheng Liu, Yunxia Wang   +4 more
doaj   +1 more source