Results 21 to 30 of about 51,717 (306)
HMGB1 in inflammation and cancer [PDF]
Journal of Hematology & Oncology, 2020 AbstractHigh mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability maintenance. In response to stimulus like bacteria or chemoradiotherapy, HMGB1 can translocate to extracellular context as a danger alarmin, activate the immune ...
Shumin Wang, Yi Zhang
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HMGB1: A pleiotropic activity [PDF]
Pediatric Allergy and Immunology, 2020 AbstractHigh‐mobility group box 1 (HMGB1) is a nuclear protein involved in DNA replication, transcription, recombination, and repair. In the extracellular space, the HMGB1 plays an essential role in the onset and perpetuation of inflammation, belonging to the group of damage‐associated molecular pattern (DAMP) molecules, also called alarmins. For this,
Colavita, Laura +3 more
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Virulence, 2021 High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, can be released into extracellular space and function as a strong proinflammatory cytokine, which plays critical roles in the pathogenesis of various inflammatory diseases.
Wenqing Fan +3 more
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Journal of Behçet Uz Children's Hospital, 2023 Objective: Familial Mediterranean fever (FMF) is an autoinflammatory disease that commonly presents with fever, peritonitis, and pleuritis. Recent studies have reported ongoing inflammation in the attack-free period of patients with FMF.
Betül Öztürk +5 more
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Медицинская иммунология, 2022 Chronic non-infectious inflammation of low intensity is the most important mechanism of development and progression in atherosclerosis. Under the conditions of persistent non-resolving inflammation observed in the vascular wall and atherosclerotic plaque
V. V. Genkel +8 more
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Targeting HMGB1 in inflammation [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010 High mobility group box 1 (HMGB1), a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. Elevated levels of HMGB1 in serum and tissues occur during sterile tissue injury and during infection, and ...
Huan, Yang, Kevin J, Tracey
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The cytokine activity of HMGB1 [PDF]
Journal of Leukocyte Biology, 2005 AbstractHigh mobility group box 1 (HMGB1) is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types. We recently discovered that HMGB1 is secreted into the extracellular milieu and acts as a proinflammatory cytokine.
Huan, Yang +3 more
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HMGB1 in health and disease [PDF]
Molecular Aspects of Medicine, 2014 Complex genetic and physiological variations as well as environmental factors that drive emergence of chromosomal instability, development of unscheduled cell death, skewed differentiation, and altered metabolism are central to the pathogenesis of human diseases and disorders.
Rui, Kang +17 more
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The mechanism of HMGB1 secretion and release [PDF]
Experimental & Molecular Medicine, 2022 AbstractHigh mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone that maintains the structure and function of chromosomes. In the cytoplasm, HMGB1 can promote autophagy by binding to BECN1 protein.
Chen, Ruochan, Kang, Rui, Tang, Daolin
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, 2021 Molecular studies have proven beneficial in understanding the pathophysiology of PD. Besides, the advancing application of zebrafish as a PD model has enabled researchers to conduct molecular studies with more promising outcomes and significance. Current
Mohamed, Wael +6 more
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