Results 1 to 10 of about 135,792 (165)
TLR4: the fall guy in sepsis? [PDF]
Cell Stress, 2020 Sepsis and its impact on human health can be traced back to 1000 BC and continues to be a major health burden today. It causes about 11 million deaths world-wide of which, more than a third are due to neonatal sepsis.
Joseph Menassa +3 more
doaj +3 more sources
EMBO ReportsAbstract Toll-like receptor 4 (TLR4) signaling at the plasma membrane and in endosomes results in distinct contributions to inflammation and host defence. Current understanding indicates that endocytosis of cell surface-activated TLR4 is required to enable subsequent signaling from endosomes.
Boštjan Kobe +2 more
exaly +5 more sources
Polymorphism study of TLR4 gene in crossbred cattle of Kerala [PDF]
Journal of Veterinary and Animal Sciences, 2023 The present study was conducted to identify single nucleotide variations in exon 3 region of the bovine Toll-Like Receptor gene (TLR4) associated with somatic cell score (SCS) in crossbred cattle of Kerala using polymerase chain reaction-single ...
G. Chishi Kiyevi +5 more
doaj +1 more source
Effects of Escherichia coli lipopolysaccharide on innate immunity: The expression profile of TLR4 and CD14 genes in rat's liver [PDF]
Open Veterinary Journal, 2021 Background: Bacterial Endotoxin (lipopolysaccharide) is essential for bacterial virulence, as it has a biphasic effect which is either harmful and leads to aseptic shock and death or assists the body defense mechanisms as it stimulates B-cells activation.
Ammar M. Al-Aalim +2 more
doaj +1 more source
Inflammatory signaling of HMGB1 in depressive disorder
Stress and Brain, 2023 Background:Depressive disorder is a common disease characterized by depressed mood and loss of pleasure, which often brings a great grief to patients and a huge burden to the society.
Qian Jiang +4 more
doaj +1 more source
Virulence, 2021 Whole-cell vaccines against Gram-negative bacteria commonly display high reactogenicity caused by the endotoxic activity of lipopolysaccharide (LPS), one of the major components of the bacterial outer membrane. Underacylation of the lipid A moiety of LPS
Jesús Pérez-Ortega +7 more
doaj +1 more source
TLR4 and Insulin Resistance [PDF]
Gastroenterology Research and Practice, 2010 Chronic inflammation is a key feature of insulin resistance and obesity. Toll-Like Receptor 4 (TLR4), involved in modulating innate immunity, is an important mediator of insulin resistance and its comorbidities. TLR4 contributes to the development of insulin resistance and inflammation through its activation by elevated exogenous ligands (e.g., dietary
Jane J. Kim, Dorothy D. Sears
openaire +4 more sources
The Prophylactic Use of Bovine Colostrum in a Murine Model of TNBS-Induced Colitis
Animals, 2020 This study investigated the effects of a short-term administration of bovine colostrum (BC) in a TNBS model of induced colitis. Colitis was induced by TNBS treatment after seven days of BC (BC group, n = 12) or saline (control group, n = 12 ...
Laura Menchetti +13 more
doaj +1 more source
The role of Toll-like receptors in chemoradiotherapy-induced gastrointestinal mucositis
口腔疾病防治, 2021 Mucositis is a common gastrointestinal complication in cancer patients undergoing chemoradiotherapy, including oral mucositis and gastrointestinal mucositis, with clinical manifestations of oral ulcers, vomiting, diarrhea and pain that seriously reduce ...
JI Ling +3 more
doaj +1 more source
Pathogens, 2020 Bovine mastitis is the inflammatory reaction of the mammary gland and is commonly caused by bacterial infections in high-yielding dairy cows. The detailed investigation of the immunotranscriptomic response of bovine mammary epithelial (BME) cells to ...
Md. Aminul Islam +12 more
doaj +1 more source