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TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation [PDF]
EMBO ReportsAbstract Toll-like receptor 4 (TLR4) signaling at the plasma membrane and in endosomes results in distinct contributions to inflammation and host defence. Current understanding indicates that endocytosis of cell surface-activated TLR4 is required to enable subsequent signaling from endosomes.
Boštjan Kobe +2 more
exaly +6 more sources
TLR4: the fall guy in sepsis? [PDF]
Cell Stress, 2020 Sepsis and its impact on human health can be traced back to 1000 BC and continues to be a major health burden today. It causes about 11 million deaths world-wide of which, more than a third are due to neonatal sepsis.
Joseph Menassa +3 more
doaj +3 more sources
TLR4 knockdown by miRNA-140-5p improves tendinopathy: an in vitr o study
Archives of Medical Science, 2020 Introduction The purpose of this study was to determine whether TLR4 knockdown induced by miRNA-140-5p improves tendinopathy in an in vitro experiment. Material and methods Extraction of tendon-derived stem cells (TDSCs) from SD rats was performed using
Tu Jun, Guo Ruipeng, Xu Bin
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TLR4 Antagonism Reduces Movement-Induced Nociception and ATF-3 Expression in Experimental Osteoarthritis [PDF]
Journal of Pain Research, 2021 Joana Ferreira-Gomes,1,2 Miguel M Garcia,3– 5 Diana Nascimento,1,2 Lígia Almeida,1,2 Ernesto Quesada,3,5 José Manuel Castro-Lopes,1,2 David Pascual,3– 5 Carlos Goicoechea,3– 5 Fani Lourença Neto1,2 1i3S - Instituto de Investigação e Inovação em Saúde ...
Ferreira-Gomes J +8 more
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