Results 1 to 10 of about 172,294 (303)

TLR4: the fall guy in sepsis? [PDF]

Cell Stress, 2020
Sepsis and its impact on human health can be traced back to 1000 BC and continues to be a major health burden today. It causes about 11 million deaths world-wide of which, more than a third are due to neonatal sepsis.
Joseph Menassa, Christina Nedeva, Corey Pollock, Hamsa Puthalakath   +3 more
doaj   +3 more sources

Polymorphism study of TLR4 gene in crossbred cattle of Kerala [PDF]

Journal of Veterinary and Animal Sciences, 2023
The present study was conducted to identify single nucleotide variations in exon 3 region of the bovine Toll-Like Receptor gene (TLR4) associated with somatic cell score (SCS) in crossbred cattle of Kerala using polymerase chain reaction-single ...
G. Chishi Kiyevi, Valsalan Jamuna , Sadan Tina, K. Anilkumar, T. V. Aravindakshan, K. Radha   +5 more
doaj   +1 more source

Effects of Escherichia coli lipopolysaccharide on innate immunity: The expression profile of TLR4 and CD14 genes in rat's liver [PDF]

Open Veterinary Journal, 2021
Background: Bacterial Endotoxin (lipopolysaccharide) is essential for bacterial virulence, as it has a biphasic effect which is either harmful and leads to aseptic shock and death or assists the body defense mechanisms as it stimulates B-cells activation.
Ammar M. Al-Aalim, Ali A. Al-iedani, Mohammad A. Hamad   +2 more
doaj   +1 more source

Inflammatory signaling of HMGB1 in depressive disorder

Stress and Brain, 2023
Background:Depressive disorder is a common disease characterized by depressed mood and loss of pleasure, which often brings a great grief to patients and a huge burden to the society.
Qian Jiang, Chaoran Li, Huijing Xu, Taosheng Liu, Yunxia Wang   +4 more
doaj   +1 more source

Reduction of endotoxicity in Bordetella bronchiseptica by lipid A engineering: Characterization of lpxL1 and pagP mutants

Virulence, 2021
Whole-cell vaccines against Gram-negative bacteria commonly display high reactogenicity caused by the endotoxic activity of lipopolysaccharide (LPS), one of the major components of the bacterial outer membrane. Underacylation of the lipid A moiety of LPS
Jesús Pérez-Ortega, Roel M. Van Harten, Ria Van Boxtel, Michel Plisnier, Marc Louckx, Dominique Ingels, Henk P. Haagsman, Jan Tommassen   +7 more
doaj   +1 more source

The Prophylactic Use of Bovine Colostrum in a Murine Model of TNBS-Induced Colitis

Animals, 2020
This study investigated the effects of a short-term administration of bovine colostrum (BC) in a TNBS model of induced colitis. Colitis was induced by TNBS treatment after seven days of BC (BC group, n = 12) or saline (control group, n = 12 ...
Laura Menchetti, Giulio Curone, Iulia Elena Filipescu, Olimpia Barbato, Leonardo Leonardi, Gabriella Guelfi, Giovanna Traina, Patrizia Casagrande-Proietti, Federica Riva, Anna Beatrice Casano, Federica Piro, Daniele Vigo, Alda Quattrone, Gabriele Brecchia   +13 more
doaj   +1 more source

The role of Toll-like receptors in chemoradiotherapy-induced gastrointestinal mucositis

口腔疾病防治, 2021
Mucositis is a common gastrointestinal complication in cancer patients undergoing chemoradiotherapy, including oral mucositis and gastrointestinal mucositis, with clinical manifestations of oral ulcers, vomiting, diarrhea and pain that seriously reduce ...
JI Ling, WANG Jiahe, WANG Jiantao, Wang Yan   +3 more
doaj   +1 more source

Transcriptome Analysis of The Inflammatory Responses of Bovine Mammary Epithelial Cells: Exploring Immunomodulatory Target Genes for Bovine Mastitis

Pathogens, 2020
Bovine mastitis is the inflammatory reaction of the mammary gland and is commonly caused by bacterial infections in high-yielding dairy cows. The detailed investigation of the immunotranscriptomic response of bovine mammary epithelial (BME) cells to ...
Md. Aminul Islam, Michihiro Takagi, Kohtaro Fukuyama, Ryoya Komatsu, Leonardo Albarracin, Tomonori Nochi, Yoshihito Suda, Wakako Ikeda-Ohtsubo, Victor Rutten, Willem van Eden, Julio Villena, Hisashi Aso, Haruki Kitazawa   +12 more
doaj   +1 more source

Ursolic acid induces the production of IL6 and chemokines in both adipocytes and adipose tissue

Adipocyte, 2020
Adipose tissue inflammation plays an important role in the regulation of glucose and lipids metabolism. It is unknown whether Ursolic acid (UA) could regulate adipose tissue inflammation, though it can regulate inflammation in many other tissues. In this
Bin Feng, Yingguo Zhu, Lijun Yan, Hui Yan, Xiaohua Huang, Dandan Jiang, Zhen Li, Lun Hua, Yong Zhuo, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Chao Huang, Yuanfeng Zou, Lixia Li, De Wu   +16 more
doaj   +1 more source

The Defensive Action of LYRM03 on LPS-Induced Acute Lung Injury by NF-κB/TLR4/NLRP3 Signals

Journal of Investigative Surgery, 2021
The aim of the current investigation was to study the role of 3-amino-2-hydroxy-4-phenyl-valyl-isoleucine (LYRM03) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and investigate its potential pathogenesis.
Bin Wang, Jiaoyue Wang, Daopeng Lu, Na Qi, Qin Liu   +4 more
doaj   +1 more source