Results 11 to 20 of about 135,891 (264)

Ursolic acid induces the production of IL6 and chemokines in both adipocytes and adipose tissue

Adipocyte, 2020
Adipose tissue inflammation plays an important role in the regulation of glucose and lipids metabolism. It is unknown whether Ursolic acid (UA) could regulate adipose tissue inflammation, though it can regulate inflammation in many other tissues. In this
Bin Feng, Yingguo Zhu, Lijun Yan, Hui Yan, Xiaohua Huang, Dandan Jiang, Zhen Li, Lun Hua, Yong Zhuo, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Chao Huang, Yuanfeng Zou, Lixia Li, De Wu   +16 more
doaj   +1 more source

Interaction of Opioids with TLR4—Mechanisms and Ramifications [PDF]

Cancers, 2021
The innate immune receptor toll-like receptor 4 (TLR4) is known as a sensor for the gram-negative bacterial cell wall component lipopolysaccharide (LPS). TLR4 activation leads to a strong pro-inflammatory response in macrophages; however, it is also recognised to play a key role in cancer.
Mai Mahmoud Gabr, Iqira Saeed, Jared A. Miles, Benjamin P. Ross, Paul Nicholas Shaw, Markus W. Hollmann, Marie-Odile Parat   +6 more
openaire   +5 more sources

The Defensive Action of LYRM03 on LPS-Induced Acute Lung Injury by NF-κB/TLR4/NLRP3 Signals

Journal of Investigative Surgery, 2021
The aim of the current investigation was to study the role of 3-amino-2-hydroxy-4-phenyl-valyl-isoleucine (LYRM03) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and investigate its potential pathogenesis.
Bin Wang, Jiaoyue Wang, Daopeng Lu, Na Qi, Qin Liu   +4 more
doaj   +1 more source

Paroxetine effect on expression of TLR2 and TLR4 genes in PBMCs of mentally normal individuals [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2021
Background: Paroxetine is one of the well-known antidepressants. Recent studies have focused on paroxetine’s probable immuno-modulatory effects, since findings have indicated inflammation’s role in the pathophysiology of depression.
Fatemeh Ganjalishahi, Anahid Hemmatpur, Mahdi Dehghan manshadi, Hossein Hadi nedoushan, Alireza Karimollah   +4 more
doaj   +1 more source

Biallelic TLR4 deficiency in humans

Journal of Allergy and Clinical Immunology, 2023
Toll-like receptors (TLRs) mediate functions for host defense and inflammatory responses. TLR4 recognizes LPS, a component of gram-negative bacteria as well as host-derived endogenous ligands such as S100A8 and S100A9 proteins.We sought to report phenotype and cellular function of individuals with complete TLR4 deficiency.We performed genome sequencing
Melania Capitani, Ahmad A. Al-Shaibi, Sumeet Pandey, Lisa Gartner, Henry Taylor, Satanay Z. Hubrack, Nourhen Agrebi, Muneera Jassim Al-Mohannadi, Saad Al Kaabi, Thomas Vogl, Johannes Roth, Daniel Kotlarz, Christoph Klein, Adrian K. Charles, Vinayan Vijayakumar, Mohammed Yousuf Karim, Bruce George, Simon P. Travis, Mamoun Elawad, Bernice Lo, Holm H. Uhlig   +20 more
openaire   +3 more sources

Decursin negatively regulates LPS-induced upregulation of the TLR4 and JNK signaling stimulated by the expression of PRP4 in vitro

Animal Cells and Systems, 2020
The current investigation was carried out to analyze the correlation of bacterial lipopolysaccharide (LPS) and pre-mRNA processing factor 4B (PRP4) in inducing inflammatory response and cell actin cytoskeleton rearrangement in macrophages (Raw 264.7) and
Muhammad Bilal Ahmed, Salman Ul Islam, Young Sup Lee   +2 more
doaj   +1 more source

Effects of three types of fresh Rehmannia glutinosa improve lipopolysaccharide-induced acute kidney injury in sepsis through the estrogen receptor pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): To explore the effects and mechanism of three types of fresh Rehmannia glutinosa, namely Beijing No. 3 (BJ3H), Huaizhong No. 1 (HZ1H), and Taisheng (TS) on lipopolysaccharide (LPS)-induced acute kidney injury in the sepsis (S-AKI) mice ...
Meng Liu, Mengnan Zeng, Pengli Guo, Yuhan Zhang, Xiaofeng Yang, Jufang Jia, Qinqin Zhang, Beibei Zhang, Bing Cao, Ru Wang, Xiaoke Zheng, Weisheng Feng   +11 more
doaj   +1 more source

PPAR γ/TLR4/TGF-β1 axis mediates the protection effect of erythropoietin on cyclosporin A-induced chronic nephropathy in rat

Renal Failure, 2020
Objective Nephrotoxicity is the main side effect of cyclosporine A and finding an effective combating method is urgent. The present study investigates the improving effect of erythropoietin (EPO) on cyclosporine A induce renal injury in rats and further ...
Bin Liu, Ping Tan
doaj   +1 more source

TLR4/MyD88/PI3K interactions regulate TLR4 signaling

Journal of Leukocyte Biology, 2009
AbstractTLRs activate immune responses by sensing microbial structures such as bacterial LPS, viral RNA, and endogenous “danger” molecules released by damaged host cells. MyD88 is an adapter protein that mediates signal transduction for most TLRs and leads to activation of NF-κB and MAPKs and production of proinflammatory cytokines.
Michelle H W, Laird, Sang Hoon, Rhee, Darren J, Perkins, Andrei E, Medvedev, Wenji, Piao, Matthew J, Fenton, Stefanie N, Vogel   +6 more
openaire   +3 more sources

Inflammatory response modulation by epinephrine and norepinephrine

RUDN Journal of Medicine, 2023
Relevance. Inflammation is a defense response of an organism to a pathogen. It appears in order to maintain homeostasis and is regulated by the immune, nervous, and endocrine systems.
Svetlana V. Guryanova, Artem S. Ferberg, Ilya A. Sigmatulin   +2 more
doaj   +1 more source