Results 11 to 20 of about 272,563 (343)

Toll-like receptor 4 (TLR4): new insight immune and aging

Immunity & Ageing, 2023
TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane’s surface but also interacts with intracellular ligands, initiating intricate intracellular ...
Hyo-Jin Kim, Hyemin Kim, Jeong-Hyung Lee, C. Hwangbo   +3 more
semanticscholar   +1 more source

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

Mediators of Inflammation, 2021
Causes of mortality from COVID‐19 include respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that recognizes pathogen‐associated molecular patterns (PAMPs) including viral proteins and
Mohamed M. Aboudounya, R. Heads
semanticscholar   +1 more source

TLR4 regulates RORγt+ regulatory T-cell responses and susceptibility to colon inflammation through interaction with Akkermansia muciniphila

Microbiome, 2022
Background Well-balanced interactions between gut microbiota and the immune system are essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel diseases (IBD). Toll-like receptor 4 (TLR4) functions as a sensor mediating the
Yaojiang Liu, Min Yang, Li Tang, Fengchao Wang, Shengjie Huang, Shuang Liu, Yuanyuan Lei, Sumin Wang, Zhuo Xie, Wei Wang, Xiaoyan Zhao, Bo Tang, Shiming Yang   +12 more
semanticscholar   +1 more source

TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection

Nature Communications, 2021
TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate immune cells encounter different mechanical cues in both health and disease to adapt their behaviors.
Jing Geng, Yiran Shi, Jinjia Zhang, Bingying Yang, Ping Wang, Weihong Yuan, Hao Zhao, Junhong Li, Funiu Qin, Lixin Hong, Changchuan Xie, Xianming Deng, Yujie Sun, Congying Wu, Lanfen Chen, Dawang Zhou   +15 more
semanticscholar   +1 more source

Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway

International Journal of Molecular Sciences, 2022
TLR4/NF-κB is a key inflammatory signaling transduction pathway, closely involved in cell differentiation, proliferation, apoptosis, and pro-inflammatory response.
Caiyun Yu, D. Wang, Zaibin Yang, Tian Wang   +3 more
semanticscholar   +1 more source

Ursolic acid induces the production of IL6 and chemokines in both adipocytes and adipose tissue

Adipocyte, 2020
Adipose tissue inflammation plays an important role in the regulation of glucose and lipids metabolism. It is unknown whether Ursolic acid (UA) could regulate adipose tissue inflammation, though it can regulate inflammation in many other tissues. In this
Bin Feng, Yingguo Zhu, Lijun Yan, Hui Yan, Xiaohua Huang, Dandan Jiang, Zhen Li, Lun Hua, Yong Zhuo, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Chao Huang, Yuanfeng Zou, Lixia Li, De Wu   +16 more
doaj   +1 more source

Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. [PDF]

, 2019
We previously reported that the canonical innate immune receptor toll-like receptor 4 (TLR4) is critical in maintaining lung integrity. However, the molecular mechanisms via which TLR4 mediates its effect remained unclear.
Ardito, Taylor, Hwangbo, Cheol, Kim, So-Jin, Lee, Patty J, Li, Alfred, Min, Jin-Na, Peng, Tien, Sauler, Maor, Shan, Peiying, Zhang, Xuchen, Zhang, Yi   +10 more
core   +1 more source

The Defensive Action of LYRM03 on LPS-Induced Acute Lung Injury by NF-κB/TLR4/NLRP3 Signals

Journal of Investigative Surgery, 2021
The aim of the current investigation was to study the role of 3-amino-2-hydroxy-4-phenyl-valyl-isoleucine (LYRM03) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and investigate its potential pathogenesis.
Bin Wang, Jiaoyue Wang, Daopeng Lu, Na Qi, Qin Liu   +4 more
doaj   +1 more source

Paroxetine effect on expression of TLR2 and TLR4 genes in PBMCs of mentally normal individuals [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2021
Background: Paroxetine is one of the well-known antidepressants. Recent studies have focused on paroxetine’s probable immuno-modulatory effects, since findings have indicated inflammation’s role in the pathophysiology of depression.
Fatemeh Ganjalishahi, Anahid Hemmatpur, Mahdi Dehghan manshadi, Hossein Hadi nedoushan, Alireza Karimollah   +4 more
doaj   +1 more source

TLR4/MyD88/PI3K interactions regulate TLR4 signaling

Journal of Leukocyte Biology, 2009
AbstractTLRs activate immune responses by sensing microbial structures such as bacterial LPS, viral RNA, and endogenous “danger” molecules released by damaged host cells. MyD88 is an adapter protein that mediates signal transduction for most TLRs and leads to activation of NF-κB and MAPKs and production of proinflammatory cytokines.
Michelle H W, Laird, Sang Hoon, Rhee, Darren J, Perkins, Andrei E, Medvedev, Wenji, Piao, Matthew J, Fenton, Stefanie N, Vogel   +6 more
openaire   +3 more sources