Results 41 to 50 of about 170,484 (302)

TLR4 rs1927914 polymorphism contributes to serum TLR4 levels in patients with aortic aneurysm

Experimental and Molecular Pathology, 2021
Toll-like receptor 4 (TLR4) is a crucial regulator of inflammatory reactions and vascular remodeling. Elevated TLR4 expression has been proved to be correlated with an increased risk of aortic aneurysm (AA). This study aimed to explore the influence of TLR4 gene polymorphisms on TLR4 expression levels and its probable functional significance in AA ...
Tan, Li, Jingjing, Jing, Nannan, Dong, Xiaozheng, Liu, Chunyan, Ma, Jun, Yang   +5 more
openaire   +2 more sources

Delayed Resolution of Acute Inflammation in Ulcerative Colitis Is Associated with Elevated Cytokine Release Downstream of TLR4 [PDF]

, 2010
Background: Ulcerative colitis (UC) is widely viewed as a leukocyte-mediated disorder. Although strong evidence implicates an exuberant response to microbial components in its pathogenesis, no intrinsic immune defect has been identified and the ...
Bu'Hussain Hayee, Bloom, SL, Hayee, B, Daniel J B Marks, Bloom Stuart L., Segal Anthony W., Anthony W Segal, Rahman Farooq Z., Smith Andrew M., Hayee Bu'Hussain, Rahman, FZ, Andrew M Smith, Stuart L Bloom, Marks, DJB, Marks Daniel J. B., Smith, AM, Farooq Z Rahman, Segal, AW   +17 more
core   +2 more sources

Ivermectin decreases inflammation and imiquimod–induced psoriasis-like skin lesions in rat via targeting TLR4 / p65 NF-κB [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Psoriasis is a chronic skin disease that usually manifests as white and silver spots on the skin. Because of its anti-inflammatory properties, we investigated the effects of ivermectin (IVM) on imiquimod (IMQ)-induced psoriasis in rats ...
Tayebeh Noori, Antoni Sureda, Samira Shirooie   +2 more
doaj   +1 more source

Bacterial TLR4 and NOD2 signaling linked to reduced mitochondrial energy function in active inflammatory bowel disease

Gut Microbes, 2020
Inflammatory bowel disease (IBD) has been linked to active signaling with bacterial components and reduced mitochondrial ATP production; however, synergism between both of these disease characteristics remains unclear.
Emmanuelle Ruiz, Harrison M. Penrose, Sandra Heller, Hani Nakhoul, Melody Baddoo, Erik F. Flemington, Emad Kandil, Suzana D. Savkovic   +7 more
doaj   +1 more source

Association between TLR4 and PTEN Involved in LPS-TLR4 Signaling Response

BioMed Research International, 2016
In this study, we explored the potential mechanisms of how PTEN regulating LPS induced TLR4 signaling pathway. The initial findings from ELISA demonstrate that PTEN influences TNF-αsecretion by its lipid phosphatase activity. Subsequently, western blot, immunoprecipitation assay, and immunofluorescence were performed to explore the activation process ...
Huahua Yin, Yan Tan, Xiaofeng Wu, Hong Yan, Feng Liu, Yuanzhang Yao, Jianxin Jiang, Qi Wan, Lei Li   +8 more
openaire   +3 more sources

TLR4-dependent stimulation of IFN-β by ProTα variants.

, 2016
(A) IFN-β, (B) IL-6, and (C) TNF-α expression was measured by RT-qPCR on cDNAs from wild type and TLR4-/- mouse bone marrow-derived macrophages treated with 200 ng/ml of different ProTα variants for 2 h. Though at lower levels, TNF-α remains inducible by
Judith Aberg (2839373), Arevik Mosoian (175389), Avelino Teixeira (137069), G. Luca Gusella (191075), Vladimir N. Uversky (123421)   +4 more
core   +1 more source

Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations [PDF]

, 2005
AIM: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD. METHODS: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included.
Gasztonyi, Beáta, Mózsik, Gyula, Oesterreicher, Christoph, Szalay, Ferenc, Willheim-Polli, Claudia, Reinisch, Walter, Papp, János, Lakatos, Péter László, Molnár, Tamás, Altorjay, István, Tulassay, Zsolt, Ferenci, Péter, Lakatos, László   +12 more
core   +1 more source

Tuo-Min-Ding-Chuan Decoction Alleviates Airway Inflammations in the Allergic Asthmatic Mice Model by Regulating TLR4-NLRP3 Pathway-Mediated Pyroptosis: A Network Pharmacology and Experimental Verification Study

Drug Design, Development and Therapy, 2023
Mingsheng Lyu,1,2 Jingbo Qin,3 Shuaiyang Huang,2 Dongmei Shao,4 Guirui Huang,2 Fan Yang,5,6 Xuefeng Gong,7 Shiyu Zhang,2 Zhijie Zhang,2 Ji Wang,6 Hongsheng Cui2 1Center of Respiratory Disease, Dongzhimen Hospital, Beijing University of Chinese Medicine ...
Lyu M, Qin J, Huang S, Shao D, Huang G, Yang F, Gong X, Zhang S, Zhang Z, Wang J, Cui H   +10 more
doaj  

Polymorphisms of TLR4: Rapid Genotyping and Reduced Response to Lipopolysaccharide of TLR4 Mutant Alleles [PDF]

Clinical Chemistry, 2002
AbstractBackground: Pathogen recognition receptors such as Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns, lead to the activation of innate immunity. Genetic variations in these receptors may lead to an altered host immune response to pathogens.Methods: We developed homogeneous fluorescence-based PCR assays as well ...
Christopher, Schmitt, Andreas, Humeny, Cord-Michael, Becker, Kay, Brune, Andreas, Pahl   +4 more
openaire   +2 more sources

Data_Sheet_2_Dendrobium officinale Polysaccharide Protected CCl4-Induced Liver Fibrosis Through Intestinal Homeostasis and the LPS-TLR4-NF-κB Signaling Pathway.docx

, 2020
We explored the therapeutic effects of Dendrobium officinale polysaccharide (DOP) on CCl4-induced liver fibrosis with respect to the intestinal hepatic axis using a rat model.
Xiawen Yang (8552799), Hongjing Wang (1542565), Qiang Li (8118), Kaiping Wang (4441702), Hao Mei (73778), Yu Zhang (12946), Zhijing Wu (8563134), Ruxu You (2558287)   +7 more
core   +1 more source