Results 61 to 70 of about 135,891 (264)
Сибирский научный медицинский журнал, 2020 Co-occurrence of cardiovascular diseases is significantly common among patients with bronchial asthma. Genetic factors can have a significant effect on the development of hypertension in patients with asthma. Objective of the study was to investigate the
E. Y. Bragina +6 more
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Advanced Science, EarlyView.This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan +10 more
wiley +1 more source
NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity
Advanced Science, EarlyView.Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li +7 more
wiley +1 more source
TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway
Open Life SciencesDiabetic cardiomyopathy (DCM) is identified as a progressive disease that may lead to irreparable heart failure. Toll-like receptor (TLR) signaling is believed to be implicated in the pathogenesis of DCM.
Zhao Xiaolong +5 more
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Maintenance of homeostasis by TLR4 ligands
Frontiers in ImmunologyImmunotherapy is renowned for its capacity to elicit anti-infective and anti-cancer effects by harnessing immune responses to microbial components and bolstering innate healing mechanisms through a cascade of immunological reactions. Specifically, mammalian Toll-like receptors (TLRs) have been identified as key receptors responsible for detecting ...
Masataka Oda +2 more
openaire +3 more sources
Circulation Research, 2014 Platelets are small, disc-shaped cell fragments that circulate in the blood and play an important role in hemostasis. The lifespan of a platelet is ≈5 to 9 days. Emerging evidence indicates that platelets may be involved in the pathogenesis of pulmonary arterial hypertension (PAH).
openaire +2 more sources
Advanced Science, EarlyView.Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang +8 more
wiley +1 more source
Flavanomarein Protects HT22 Cells by Inhibiting LPS-induced Inflammatory Activation of BV2 Cells
Shipin gongye ke-jiObjective: To investigate the protective effects of flavonomaside on HT22 mouse hippocampal neuronal cells by inhibiting the inflammatory response induced by lipopolysaccharide (LPS) in mouse microglia (BV2) and elucidate the underlying mechanisms ...
Dongmei YANG +6 more
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Advanced Science, EarlyView.Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib +8 more
wiley +1 more source
Impact of Human Toll-Like Receptor 4 Gene Polymorphism on Infection with Trichomonas vaginalis
Medical Journal of BabylonBackground: Trichomonas vaginalis (T. vaginalis) is an anaerobic protozoan characterized by functional diagnostic flagella which are important motility tools.
Zainab Waddah Kermasha +2 more
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