Results 1 to 10 of about 225,240 (261)

EXPRESSION FEATURES OF TOLL-LIKE RECEPTOR 2 AND TOLL-LIKE RECEPTOR 4 IN CHILDREN WITH ASTHMA

Медицинская иммунология, 2017
Currently actively  discussed  the  role  of innate immunity receptors, in particular TLRs  in the immunopathogenesis of bronchial asthma (BA).The aim of our work was to study the expression of ТLR2 and TLR4 on the nasal mucosal cells and peripheral ...
L. V. Gankovskaya, L. S. Namazova-Baranova, M. V. Khoreva, B. G. Bragvadze, A. D. Ogurtsova, A. A. Alekseeva, V. А. Gankovskii, O. А. Svitich   +7 more
doaj   +3 more sources

Toll-like receptor-4 modulation for cancer immunotherapy [PDF]

Frontiers in Immunology, 2014
Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition molecules. Since the discovery of the Toll pathway cascade (1, 2), our knowledge about the structure, function, and mechanics of TLRs in infectious and inflammatory conditions has increased remarkably. The role of TLR4 as a pathogen-pattern recognition receptor has been studied
Shanjana eAwasthi
doaj   +3 more sources

How Toll-like receptors influence Parkinson’s disease in the microbiome–gut–brain axis

Frontiers in Immunology, 2023
Recently, a large number of experimenters have found that the pathogenesis of Parkinson’s disease may be related to the gut microbiome and proposed the microbiome–gut–brain axis.
Ziyi Zhang, Ziyi Zhang, Zhihui Liu, Ao Lv, Chenhui Fan   +4 more
doaj   +1 more source

Toll‐like receptor 4 in atherosclerosis [PDF]

Journal of Cellular and Molecular Medicine, 2007
Introduction Toll‐like receptor 4 structure and its functions TLR4 expression in atherosclerotic lesions Endothelial cells Vascular smooth muscle cells (VSMCs) Adventitial fibroblasts Dendritic cells (DCs) Macrophages Role of TLR4 in atherosclerosis TLR4 in early atherosclerotic lesion TLR4 in advanced atherosclerotic lesion TLR4 in plaque rupture ...
Li, Hongli, Sun, Baogui
openaire   +2 more sources

Involvement of Toll-Like Receptor 4 in Decreased Vasopressor Response Following Trauma/Hemorrhagic Shock

Critical Care Explorations, 2021
OBJECTIVES:. Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock ...
Rafi Mazor, PhD, Fernando Dos Santos, PhD, Joyce B. Li, MSc, Federico Aletti, PhD, Geert Schmid-Schonbein, PhD, Erik B. Kistler, MD, PhD   +5 more
doaj   +1 more source

Role of Toll Like Receptor 4 in Alzheimer’s Disease

Frontiers in Immunology, 2020
Long-term evidence has confirmed the involvement of an inflammatory component in neurodegenerative disorders including Alzheimer’s disease (AD). This view is supported, in part, by data suggesting that selected non-steroidal anti-inflammatory drugs ...
Maria Calvo-Rodriguez, Carmen García-Rodríguez, Carlos Villalobos, Lucía Núñez, Lucía Núñez   +4 more
doaj   +1 more source

Efficient of Toll‐Like Receptor 4 Knockout in Mouse Zygotes by CRISPER/Cas9

Novelty in Biomedicine, 2021
Background: Transgenic animals are genetically modified animals to create a specific trait that imitates an indication of pathogenesis in humans.
Delsuz Rezaee, Sara Hosseini, Vahid Jajarmi, Mohammad Salehi   +3 more
doaj   +1 more source

Toll-like Receptor 4 and Hepatic Fibrogenesis [PDF]

Seminars in Liver Disease, 2010
Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as important regulators of the inflammatory response and a functional link between inflammation and fibrosis in the chronically injured liver.
Jean-Philippe, Pradere, Juliane S, Troeger, Dianne H, Dapito, Ali A, Mencin, Robert F, Schwabe   +4 more
openaire   +2 more sources

Toll-Like Receptor 4 Wild Type Homozygozity of Polymorphisms +896 and +1196 Is Associated with High Gastrin Serum Levels and Peptic Ulcer Risk. [PDF]

PLoS ONE, 2015
Toll-like receptor 4 is a part of the innate immune system and recognizes Helicobacter pylori lipopolysaccharide. The goal of this study was to analyze the role of Toll-like receptor 4 polymorphisms +896 (rs4986790) and +1196 (rs4986791) in the ...
Vesa-Matti Pohjanen, Olli-Pekka Koivurova, Heikki Huhta, Olli Helminen, Johanna M Mäkinen, Jari M Karhukorpi, Tapio Joensuu, Pentti O Koistinen, Jarno M Valtonen, Seppo E Niemelä, Riitta A Karttunen, Tuomo J Karttunen   +11 more
doaj   +1 more source

Toll-like Receptor 4 Polymorphisms and Atherogenesis

New England Journal of Medicine, 2002
The ability to mount a prominent inflammatory response to bacterial pathogens confers an advantage in innate immune defense but may signal an increased risk of atherosclerosis. We determined whether recently discovered genetic variants of toll-like receptor 4 (TLR4) that confer differences in the inflammatory response elicited by bacterial ...
Cooke, G, Segal, S, Hill, A
openaire   +5 more sources