Results 31 to 40 of about 371,093 (352)

Sequence variants of toll like receptor 4 and late-onset Alzheimer's disease.

PLoS ONE, 2012
BackgroundToll like receptor 4 (TLR4) has been related to inflammation and beta-amyloid deposition in Alzheimer's disease (AD) brain. No study has explored the association between haplotype-tagging single nucleotide polymorphisms (htSNPs) of TLR4 and AD ...
Yen-Ching Chen, Ping-Keung Yip, Yi-Ling Huang, Yu Sun, Li-Li Wen, Yi-Min Chu, Ta-Fu Chen   +6 more
doaj   +1 more source

Identification of single nucleotide polymorphisms in Toll-like receptor candidate genes associated with tuberculosis infection in water buffalo (Bubalus bubalis) [PDF]

, 2014
Toll-like receptors play a key role in innate immunity by recognizing pathogens and activating appropriate responses. Pathogens express several signal molecules (pathogen-associated molecular patterns, PAMPs) essential for survival and pathogenicity ...
Acutis, Pier Luigi, Alfano, Flora, BARONE, AMALIA, Borriello, Giorgia, Desiato, Rosanna, Galiero, Giorgio, Lucibelli, Maria Gabriella, Maniaci, Maria Grazia, Pasquali, Paolo, Peletto, Simone, Tarantino, Michela, Urciuolo, Giovanna   +11 more
core   +1 more source

Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways [PDF]

, 2017
Objective: Toll-like receptors (TLRs) play a pivotal role in the homeostatic microflora-host crosstalk. TLR4-mediated modulation of both motility and enteric neuronal survival has been reported mainly for colon with limited information on the role of ...
Cecilia Giulivi, Cecilia Giulivi, Eleonora Napoli, Francesca Galuppini, Genny Orso, Ilaria Marsilio, Isabella Lante, Maria Cecilia Giron, Massimo Rugge, Mona Roozfarakh, Silvia Cerantola, Silvia Cerantola, Valentina Caputi   +12 more
core   +3 more sources

Toll-like receptor 2 or toll-like receptor 4 deficiency does not modify lupus in MRLlpr mice.

PLoS ONE, 2013
Systemic lupus erythematosus is an autoimmune disease with a high morbidity and nephritis is a common manifestation. Previous studies in murine lupus models have suggest a role for Toll-like receptor 2 and 4.
Simon J Freeley, Angela Giorgini, Calogero Tulone, Reena J Popat, Catherine Horsfield, Michael G Robson   +5 more
doaj   +1 more source

Tenascin‐C Aggravates Autoimmune Myocarditis via Dendritic Cell Activation and Th17 Cell Differentiation [PDF]

, 2014
Background Tenascin‐C (TN‐C), an extracellular matrix glycoprotein, appears at several important steps of cardiac development in the embryo, but is sparse in the normal adult heart.
Aonuma Kazutaka, Hiroe Michiaki, Imanaka‐Yoshida Kyoko, Kimura Taizo, Machino‐Ohtsuka Tomoko, Sakai Satoshi, Sato Akira, Tajiri Kazuko, Yasutomi Yasuhiro, Yoshida Toshimichi, 佐藤 明, 田尻 和子, 町野 智子, 酒井 俊, 青沼 和隆   +14 more
core   +1 more source

Toll‐like receptor 4 polymorphisms in Saudi population with cardiovascular diseases

Molecular Genetics & Genomic Medicine, 2019
Background Toll‐like receptors play a substantial role in innate immunity and the effects of TLR4 genetic variants on cardiovascular diseases are still largely unknown.
Abdelhabib Semlali, Mikhlid Al Mutairi, Ibrahim Oqla Alanazi, Hasan Awad Aljohi, Narasimha Reddy Parine, Abdullah Alhadheq, Abdulaziz A. Al‐Jafari, Abdulelah F. Mobeirek, Abdullah Al Amri, Jilani P. Shaik, Fatima‐zohra Filali, Mohammad Alanazi   +11 more
doaj   +1 more source

Bacterial flagellin is a dominant, stable innate immune activator in the gastrointestinal contents of mice and rats

Gut Microbes, 2023
Intestinal contents comprise the largest repository of immunogenic ligands of microbial origin. We undertook this study to assess the predominant microbe-associated molecular patterns (MAMPs) present therein and the receptors) that mediate the innate ...
Matam Vijay-Kumar, Venugopal R. Bovilla, Beng San Yeoh, Rachel M. Golonka, Piu Saha, Bina Joe, Andrew T. Gewirtz   +6 more
doaj   +1 more source

Hypoallergenic fragment of Par j 2 increases functional expression of Toll-like receptors in atopic children [PDF]

, 2006
Parietaria judaica (Par j) is one of the main causes of allergy in the Mediterranean countries. The activation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) inhibits nasal inflammation of atopic ...
Bonsignore, G, Bousquet, J, Bruno, A, Duro, G, Ferraro, M, Gjomarkaj, M., LA GRUTTA, Stefania, Pace, E   +7 more
core   +1 more source

TOLL-LIKE RECEPTORS (TLR) 2 AND 4 EXPRESSION OF KERATINOCYTES FROM PATIENTS WITH LOCALIZED AND DISSEMINATED DERMATOPHYTOSIS

Revista do Instituto de Medicina Tropical de São Paulo, 2015
There are few studies on the role of innate immune response in dermatophytosis. An investigation was conducted to define the involvement of Toll-Like Receptors (TLRs) 2 and 4 in localized (LD) and
Cristiane Beatriz de Oliveira, Cídia Vasconcellos, Neusa Y. Sakai-Valente, Mirian Nacagami Sotto, Fernanda Guedes Luiz, Walter Belda JÚNIOR, Maria da Gloria Teixeira de Sousa, Gil Benard, Paulo Ricardo Criado   +8 more
doaj   +1 more source

Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation

Nature Communications, 2019
The enzyme nicotinate phosphoribosyltransferase (NAPRT) mediates the rate-limiting step in NAD salvage pathway starting from nicotinic acid. Here the authors show that NAPRT can be detected extracellularly, binds to Toll like receptor 4, and activates NF-
Antonella Managò, Valentina Audrito, Francesca Mazzola, Leonardo Sorci, Federica Gaudino, Katiuscia Gizzi, Nicoletta Vitale, Danny Incarnato, Gabriele Minazzato, Alice Ianniello, Antonio Varriale, Sabato D’Auria, Giulio Mengozzi, Gianfranco Politano, Salvatore Oliviero, Nadia Raffaelli, Silvia Deaglio   +16 more
doaj   +1 more source