Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4
Immunology, 2004 SummaryAn understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort to provide a molecular basis for the lethal effect of LPS during septic shock and point the way to novel therapies. Rapid progress in this field during the last 6 years has resulted in the discovery of not only the receptor for LPS – Toll‐like receptor 4
O'NEILL, LUKE ANTHONY JOHN, PALSSON, EVA
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Effect of Toll‐like receptor 4 on depressive‐like behaviors induced by chronic social defeat stress
Brain and Behavior, 2020 Introduction A growing body of evidence suggests that stress is an important factor in depression, and pro‐inflammatory cytokines contribute to the occurrence and development of depression in both animal models and human patients.
Ke Zhang +5 more
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Toll-like receptor 2 and Toll-like receptor 4 predict favorable prognosis in local pancreatic cancer
Tumor Biology, 2018 Toll-like receptors play an essential role in our innate immune system and are a focus of interest in contemporary cancer research. Thus far, Toll-like receptors have shown promising prognostic value in carcinomas of the oral cavity, colon, and ovaries ...
Mira A Lanki +6 more
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Hyperreactivity of Blood Leukocytes in Patients with NAFLD to Ex Vivo Lipopolysaccharide Treatment Is Modulated by Metformin and Phosphatidylcholine but Not by Alpha Ketoglutarate. [PDF]
PLoS ONE, 2015 Toll-like receptor 4 and proinflammatory cytokines play a central role in the progression of nonalcoholic fatty liver disease. We investigated IL-1, IL-6 and TNFα production and toll-like receptor 4 in both--obese and lean patients with non-alcoholic ...
Agnieszka Zwolak +4 more
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Lactobacillus acidophilus induces a slow but more sustained chemokine and cytokine response in naive foetal enterocytes compared to commensal Escherichia coli [PDF]
, 2010 The first exposure to microorganisms at mucosal surfaces is critical for immune maturation and gut health. Facultative anaerobic bacteria are the first to colonise the infant gut, and the impact of these bacteria on intestinal epithelial cells (IEC) may ...
Fink, Lisbeth Nielsen +6 more
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Toll-like receptor 4 deficiency impairs motor coordination.
Frontiers in Neuroscience, 2016 The cerebellum plays an essential role in balance and motor coordination. Purkinje cells (PCs) are the sole output neurons of the cerebellar cortex and are critical for the execution of its functions, including motor coordination.
Jianwei eZhu +4 more
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Targeting Toll‐like receptor‐4 to tackle preterm birth and fetal inflammatory injury
Clinical & Translational Immunology, 2020 Every year, 15 million pregnancies end prematurely, resulting in more than 1 million infant deaths and long‐term health consequences for many children.
Sarah A Robertson +7 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Toll-like receptor 4 limits transmission of Bordetella bronchiseptica. [PDF]
PLoS ONE, 2014 Transmission of pathogens has been notoriously difficult to study under laboratory conditions leaving knowledge gaps regarding how bacterial factors and host immune components affect the spread of infections between hosts.
Olivier Rolin +5 more
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Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
Frontiers in Cell and Developmental Biology, 2022 Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets.
Philip Mzyk +4 more
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