Results 71 to 80 of about 17,881,864 (298)

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

K63-Linked Polyubiquitination on TRAF6 Regulates LPS-Mediated MAPK Activation, Cytokine Production, and Bacterial Clearance in Toll-Like Receptor 7/8 Primed Murine Macrophages

Frontiers in Immunology, 2018
Post viral infection bacterial pneumonia is a major cause of morbidity and mortality associated with both seasonal and pandemic influenza virus illness.
Jaya Talreja, Lobelia Samavati, Lobelia Samavati   +2 more
doaj   +1 more source

Molecular alterations of the TLR4-signaling cascade in canine epilepsy

BMC Veterinary Research, 2020
Background Cumulating evidence from rodent models points to a pathophysiological role of inflammatory signaling in the epileptic brain with Toll-like receptor-4 signaling acting as one key factor.
Eva-Lotta von Rüden, Fabio Gualtieri, Katharina Schönhoff, Maria Reiber, Fabio Wolf, Wolfgang Baumgärtner, Florian Hansmann, Andrea Tipold, Heidrun Potschka   +8 more
doaj   +1 more source

The Turkey Ig-like receptor family: identification, expression and function. [PDF]

, 2012
The chicken leukocyte receptor complex located on microchromosome 31 encodes the chicken Ig-like receptors (CHIR), a vastly expanded gene family which can be further divided into three subgroups: activating CHIR-A, bifunctional CHIR-AB and inhibitory ...
Windau, Katharina, Birgit C Viertlboeck, Birgit C. Viertlboeck, Thomas W Göbel, Thomas W. Göbel, Viertlboeck, Birgit C., Göbel, Thomas W. F., Katharina Windau   +7 more
core   +2 more sources

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Effects of toll like receptor 4 (TLR4) and toll like receptor 2 (TLR 2) gene polymorphisms on clinical outcomes in acute non-biliary pancreatitis patients

Frontiers in Immunology
IntroductionIn this retrospective study, it was aimed to evaluate effects of Toll Like Receptor 4 (TLR4) and Toll Like Receptor 2 (TLR 2) gene polymorphisms on clinical outcomes in acute non-biliary pancreatitis patients.MethodsA total of 108 acute non ...
Ender Anılır, Filiz Özen, İbrahim Halil Yıldırım   +2 more
doaj   +1 more source

Expression of Toll-like receptor (TLR) 2 and TLR4 in the livers of mice infected by Clonorchis sinensis

Journal of Infection in Developing Countries, 2015
Introduction: Clonorchis sinensis is one of the most important foodborne pathogens in humans, and can cause biliary diseases such as gallstones, cholecystitis, cholangitis, and cholangiocarcinoma.
Chao Yan, Xiang-Yang Li, Bo Li, Bei-Bei Zhang, Jiang-Tao Xu, Hui Hua, Qian Yu, Zhuan-Zhuan Liu, Lin-Lin Fu, Ren-Xian Tang, Kui-Yang Zheng   +10 more
doaj   +1 more source

Characterization of Heme as Activator of Toll-like Receptor 4 [PDF]

Journal of Biological Chemistry, 2007
El hemo es una molécula antigua y ubicua presente en organismos de todos los reinos, compuesta por un átomo de hierro unido a cuatro grupos ligandos de porfirina. Una alta cantidad de hemo libre, un amplificador potencial de la respuesta inflamatoria, es un rasgo característico de las enfermedades con aumento de la hemólisis o daño celular extenso ...
Rodrigo T. Figueiredo, Patricia L. Fernández, Diego Mourão‐Sá, Bárbara Nery Porto, Fabianno F. Dutra, Letícia S. Alves, Marcus F. Oliveira, Pedro L. Oliveira, Aurélio V. Graça-Souza, Marcelo T. Bozza   +9 more
openaire   +2 more sources

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

High mobility group box 1/toll-like receptor 4/myeloid differentiation factor 88 signaling promotes progression of gastric cancer

Tumor Biology, 2017
High mobility group box 1 and toll-like receptor 4/myeloid differentiation factor 88 signaling pathway have been indicated to have oncogenic effects in many cancers.
Yanqiu Yue, Tao Zhou, Yanjing Gao, Zongli Zhang, Li Li, Lin Liu, Wenna Shi, Lihui Su, Baoquan Cheng   +8 more
doaj   +1 more source