Results 71 to 80 of about 371,093 (352)

Intestinal Dysbiosis and the Developing Lung: The Role of Toll-Like Receptor 4 in the Gut-Lung Axis. [PDF]

, 2020
BackgroundIn extremely premature infants, postnatal growth restriction (PNGR) is common and increases the risk of developing bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH). Mechanisms by which poor nutrition impacts lung development are
Chiamvimonvat, Nipavan, Gerard, Kimberly, Halloran, Katrina, Hanhauser, Ashley, Lakshminrusimha, Satyan, Monacelli, Sveva, Steinhorn, Robin H, Thai, Phung N, Underwood, Mark A, Warford, Cris, Wedgwood, Stephen   +10 more
core  

Myeloid-derived suppressor cells and associated events in urethane-induced lung cancer [PDF]

, 2013
OBJECTIVES: Myeloid-derived suppressor cells contribute to the immunosuppressive microenvironment during tumor development and limit the efficacy of cancer immunotherapy.
Almeida, Joaquim Soares de, Bueno, Valquiria, Gomes, Guiomar Nascimento, Hirata, Aparecida Emiko, Teixeira, Daniela, Visniauskas, Bruna   +5 more
core   +5 more sources

Toll-like Receptor 4 in Acute Kidney Injury

International Journal of Molecular Sciences, 2023
Acute kidney injury (AKI) is a common and devastating pathologic condition, associated with considerable high morbidity and mortality. Although significant breakthroughs have been made in recent years, to this day no effective pharmacological therapies for its treatment exist. AKI is known to be connected with intrarenal and systemic inflammation.
Patricia G. Vallés, Andrea Fernanda Gil Lorenzo, Rodrigo D. Garcia, Valeria Cacciamani, María Eugenia Benardon, Valeria Victoria Costantino   +5 more
openaire   +3 more sources

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Potential role of interleukin-33 in systemic lupus erythematosus by regulating toll like receptor 4

European Journal of Inflammation, 2022
Introduction Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune activation and multi-immunologic phenotypes. Interleukin-33 (IL-33) has been shown to be a critical and pleiotropic immunoregulatory mediator in the ...
Yi Li, Yijia Shao, Yan He, Qiugen Li, Lihua Duan   +4 more
doaj   +1 more source

Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]

, 2012
Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi, A. J. de Jesus, A. Reddy, Barochia, Bevan, Bokhari, Dziarski, H. Yin, Hargreaves, Hoshino, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, J. Thomas, Jacquet, Joce, K. Cheng, K. Ramos, Kirikae, L. C. Loram, L. R. Watkins, Lewis, Li, Liu, Liu, M. R. Hutchinson, Manavalan, Milligan, Nagyoszi, Narita, Ohto, Park, Resman, Rice, Slivka, Takeuchi, Viriyakosol, Watkins, X. Wang, Youn   +42 more
core   +2 more sources

COVID‐19 Vaccination Is Not Associated With the Development of Idiopathic Inflammatory Myositis in US Veterans

Arthritis Care &Research, EarlyView.
Objective Several case reports have proposed a potential association between COVID‐19 vaccination and the subsequent development of idiopathic inflammatory myositis (IIM). This study examined prior COVID‐19 vaccination in US veterans who developed new‐onset IIM compared to those without new‐onset IIM.
Caleb Hernández, Naomi Schlesinger, Jorge Rojas, Jessica A. Walsh, Tawnie J. Braaten, Gary A. Kunkel, Makoto Jones, Brian C Sauer, Julio Facelli, Grant W. Cannon, Dorota Lebiedz‐Odrobina   +10 more
wiley   +1 more source

Involvement of the visfatin/toll-like receptor 4 signaling axis in human dental pulp cell senescence: Protection via toll-like receptor 4 blockade

Journal of Dental Sciences, 2023
Background: /purpose: Dental pulp plays an important role in the maintenance of tooth homeostasis and repair. The aging of dental pulp affects the functional life of the tooth owing to the senescence of dental pulp cells.
Chang Youp Ok, Sera Park, Hye-Ock Jang, Moon-Kyoung Bae, Soo-Kyung Bae   +4 more
doaj   +1 more source

Immunohistochemical Expression of TLR-4 in Temporomandibular Joint Dysfunction [PDF]

, 2018
Objective Toll-like receptor 4 (TLR-4) is a transmembrane protein involved in the innate immune system and has been implicated in the pathogenesis of temporomandibular joint dysfunction (TMD).
Almeida, Luis Eduardo, Bosio, Jose A, Butcher, Seth, Camejo, Flavio, Doetzer, Andrea, Hresko, Kyle, Leonardi, Rosalia, Loreto, Carla, Sorenson, Adam, Tayebi, Lobat   +9 more
core   +2 more sources

Artificial Intelligence‐based Online Symptom Assessment Tools for Systemic Lupus Erythematosus (SLE) diagnosis: Patient Perspectives

Arthritis Care &Research, Accepted Article.
Objective The objective of this article is to identify perceptions of SLE patients regarding artificial intelligence (AI)‐based online symptom assessment tools, and the potential of these tools to address diagnostic barriers. Methods Adults from our SLE research cohort were invited to participate in 60‐90 minute virtual focus groups concerning their ...
Olivia A. Stein, Jennifer LF. Lee, Evelyne Vinet, Arielle Mendel, Christian A. Pineau, Fares Kalache, Louis‐Pierre Grenier, Sasha Bernatsky   +7 more
wiley   +1 more source