Results 1 to 10 of about 235,350 (119)

How Toll-like receptors influence Parkinson’s disease in the microbiome–gut–brain axis

Frontiers in Immunology, 2023
Recently, a large number of experimenters have found that the pathogenesis of Parkinson’s disease may be related to the gut microbiome and proposed the microbiome–gut–brain axis.
Ziyi Zhang, Ziyi Zhang, Zhihui Liu, Ao Lv, Chenhui Fan   +4 more
doaj   +1 more source

Response of Human Toll–Like Receptor 2 During the Infection of Leptospirosis

International Journal of Infectious Diseases, 2022
Purpose: Since Toll-like receptor2 (TLR2) plays a key role in mediating the innate immune responses in mice models against leptospirosis, we aimed to determine the response of human TLR2 during the infection of pathogenic Leptospira spp.
C. Kappagoda, I. Senavirathna, J. Warnasekara, S. Srimantha, N. De Silva, S. Agampodi   +5 more
doaj   +1 more source

Immunological study of orthodontically treated patients recovering from COVID-19 in Babylon Province, Iraq

Medical Journal of Babylon, 2023
Background and Objectives: This study aimed to examine the levels of the toll-like receptors TLR4 and TLR2 in the blood and saliva of patients with coronavirus disease-2019 (COVID-19) receiving orthodontic care in Babylon Province. Materials and Methods:
Basma Abdel Khaleq Eidan, Thaer Jaber Al-Khafaji, Ahmed Mohammed Abbas   +2 more
doaj   +1 more source

Involvement of Toll-Like Receptor 4 in Decreased Vasopressor Response Following Trauma/Hemorrhagic Shock

Critical Care Explorations, 2021
OBJECTIVES:. Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock ...
Rafi Mazor, PhD, Fernando Dos Santos, PhD, Joyce B. Li, MSc, Federico Aletti, PhD, Geert Schmid-Schonbein, PhD, Erik B. Kistler, MD, PhD   +5 more
doaj   +1 more source

AhR Regulates Peptidoglycan-Induced Inflammatory Gene Expression in Human Keratinocytes

Journal of Innate Immunity, 2021
Bacterial peptidoglycan (PGN) stimulates toll-like receptor 2 (TLR2) on the surface of keratinocytes (KCs), triggering signaling pathways that promote an innate immune response.
Lanqi Wang, Binbin Cheng, Qiang Ju, Bryan K. Sun   +3 more
doaj   +1 more source

Pulmonary tuberculosis susceptibility and association with Toll-Like receptor 2 Arg753Gln polymorphism

Journal of Infection in Developing Countries, 2022
Introduction: Tuberculosis has been a concern of healthcare professionals due to the serious threats it poses on public health safety. However, regardless all the efforts, no appropriate goals for immunological diagnosis or tuberculosis treatment were ...
Eman A El-Masry, Ibrahim Taher, Helal F Hetta, Samy S Eldahdouh   +3 more
doaj   +1 more source

Toll-like receptor 2 or toll-like receptor 4 deficiency does not modify lupus in MRLlpr mice.

PLoS ONE, 2013
Systemic lupus erythematosus is an autoimmune disease with a high morbidity and nephritis is a common manifestation. Previous studies in murine lupus models have suggest a role for Toll-like receptor 2 and 4.
Simon J Freeley, Angela Giorgini, Calogero Tulone, Reena J Popat, Catherine Horsfield, Michael G Robson   +5 more
doaj   +1 more source

TOLL-LIKE RECEPTORS (TLR) 2 AND 4 EXPRESSION OF KERATINOCYTES FROM PATIENTS WITH LOCALIZED AND DISSEMINATED DERMATOPHYTOSIS

Revista do Instituto de Medicina Tropical de São Paulo, 2015
There are few studies on the role of innate immune response in dermatophytosis. An investigation was conducted to define the involvement of Toll-Like Receptors (TLRs) 2 and 4 in localized (LD) and
Cristiane Beatriz de Oliveira, Cídia Vasconcellos, Neusa Y. Sakai-Valente, Mirian Nacagami Sotto, Fernanda Guedes Luiz, Walter Belda JÚNIOR, Maria da Gloria Teixeira de Sousa, Gil Benard, Paulo Ricardo Criado   +8 more
doaj   +1 more source

The Immunological Changes in the Skin of BALC/c Mice with Disseminated Acanthamoebiasis

Pathogens, 2023
Toll-like receptors (TLR) are involved in the recognition of numerous pathogens, including Acanthamoeba spp. Thanks to this, it is possible for immune cells to recognize microorganisms and trigger the body’s innate immune response.
Agnieszka Wojtkowiak-Giera, Monika Derda, Natalia Łanocha-Arendarczyk, Agnieszka Kolasa, Karolina Kot, Joanna Walczykiewicz, Piotr Solarczyk, Danuta Kosik-Bogacka   +7 more
doaj   +1 more source

Decreased Toll-like Receptor (TLR) 2 and 4 Expression in Spermatozoa in Couples with Unexplained Recurrent Spontaneous Abortion (URSA)

Iranian Journal of Allergy, Asthma and Immunology, 2019
Studies have shown that toll-like receptors (TLRs) play some important roles in reproductive processes such as ovulation, spermatogenesis, sperm capacitation, fertilization, and pregnancy to the best of our knowledge, no study has evaluated the ...
Nasrin Sereshki, Alireza Andalib, Ataollah Ghahiri, Ferdos Mehrabian, Roya Sherkat, Abbas Rezaei   +5 more
doaj   +1 more source