Results 11 to 20 of about 100,532,293 (204)

Toll-like receptor 2 and Toll-like receptor 4 predict favorable prognosis in local pancreatic cancer [PDF]

Tumor Biology, 2018
Toll-like receptors play an essential role in our innate immune system and are a focus of interest in contemporary cancer research. Thus far, Toll-like receptors have shown promising prognostic value in carcinomas of the oral cavity, colon, and ovaries ...
Mira A Lanki, Hanna E Seppänen, Harri K Mustonen, Camilla Böckelman, Anne T Juuti, Jaana K Hagström, Caj H Haglund   +6 more
doaj   +5 more sources

EXPRESSION FEATURES OF TOLL-LIKE RECEPTOR 2 AND TOLL-LIKE RECEPTOR 4 IN CHILDREN WITH ASTHMA

Медицинская иммунология, 2017
Currently actively  discussed  the  role  of innate immunity receptors, in particular TLRs  in the immunopathogenesis of bronchial asthma (BA).The aim of our work was to study the expression of ТLR2 and TLR4 on the nasal mucosal cells and peripheral ...
L. V. Gankovskaya, L. S. Namazova-Baranova, M. V. Khoreva, B. G. Bragvadze, A. D. Ogurtsova, A. A. Alekseeva, V. А. Gankovskii, O. А. Svitich   +7 more
doaj   +3 more sources

Ulvan Activates Chicken Heterophils and Monocytes Through Toll-Like Receptor 2 and Toll-Like Receptor 4 [PDF]

Frontiers in Immunology, 2018
Responsiveness to invasive pathogens, clearance via the inflammatory response, and activation of appropriate acquired responses are all coordinated by innate host defenses.
Nathalie Guriec, Frédérick Bussy, Christelle Gouin, Olivier Mathiaud, Benoit Quero, Matthieu Le Goff, Pi Nyvall Collén   +6 more
doaj   +3 more sources

Toll-like Receptor 2 in Autoimmune Inflammation

Immune Network, 2021
TLR signaling is critical for broad scale immune recognition of pathogens and/or danger molecules. TLRs are particularly important for the activation and the maturation of cells comprising the innate immune response. In recent years it has become apparent that several different TLRs regulate the function of lymphocytes as well, albeit to a lesser ...
Kathryne E. Marks, Kaylin Cho, Courtney Stickling, Joseph M. Reynolds   +3 more
openaire   +2 more sources

Toll-like receptor 2 signalling and inflammation [PDF]

Annals of the Rheumatic Diseases, 2005
Toll-like receptors (TLRs) are a family of proteins that are involved in the initial phase of host defence against invading pathogens. TLRs act as primary sensors of microbial products and activate signalling pathways that lead to the induction of immune and inflammatory genes.1 TLRs belong to a broader family of proteins, which include receptors for ...
F Y, Liew, M, Patel, D, Xu
openaire   +2 more sources

Herpesviral infection and Toll-like receptor 2 [PDF]

Protein & Cell, 2012
In the last decade, substantial progress has been made in understanding the molecular mechanisms involved in the initial host responses to viral infections. Herpesviral infections can provoke an inflammatory cytokine response, however, the innate pathogen-sensing mechanisms that transduce the signal for this response are poorly understood.
Ming-sheng, Cai, Mei-li, Li, Chun-fu, Zheng   +2 more
openaire   +2 more sources

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer [PDF]

Immunity, 2009
Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA complexes.
Kang, JY Kang, Jin Young, Nan, X Nan, Xuehua, Jin, MS Jin, Mi Sun, Youn, SJ Youn, Suk-Jun, Ryu, YH Ryu, Young Hee, Mah, S Mah, Shinjee, Han, SH Han, Seung Hyun, Lee, H Lee, Hayyoung, Paik, SG Paik, Sang-Gi, Lee, JO Lee, Jie-Oh   +9 more
openaire   +3 more sources

A study of the modulation of Toll-like receptor signalling in macrophages by Annexin-1 [PDF]

, 2011
PhDAnnexin-A1 (AnxA1) is an endogenous anti-inflammatory protein that has been shown to exert a protective role against the lethal effects induced by the Toll-like receptor (TLR) 4 agonist lipopolysaccharide (LPS).
Polycarpou, Anastasia
core   +4 more sources

Distribution of Toll‐like receptor 1 and Toll‐like receptor 2 in human lymphoid tissue [PDF]

Immunology, 2003
SummaryTo determine how distinct receptors of the immune system can contribute to innate immunity, we investigated the pattern of Toll‐like receptor 1 (TLR1) and TLR2 expression in human lymphoid tissue. We found that TLR1 and TLR2 were co‐expressed on cells of the innate immune system, including macrophages and dendritic cells.
Maria-Teresa, Ochoa, Annaliza J, Legaspi, Zena, Hatziris, Paul J, Godowski, Robert L, Modlin, Peter A, Sieling   +5 more
openaire   +2 more sources

Alternate transcription of the Toll-like receptor signaling cascade [PDF]

, 2006
Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr) cascade has been shown to dramatically alter the signaling capacity of inflammatory cells, but it is not known how common this mechanism is. We provide transcriptional evidence
Kai, Chikatoshi, Forrest, A, Schroder, K, Forrest, Alistair, Kawai, J, Kawaji, H, Wells, Christine A, Faulkner, G, Carninci, P, Hume, DA, Carninci, Piero, Grimmond, SM, Himes, SR, Lo, Sandra, Schroder, Kate, Taylor, D, Grimmond, Sean M, Faulkner, Geoffrey, Kasukawa, T, Himes, S Roy, Kawai, Jun, Waddell, Nic, Hayashizaki, Yoshihide, Kasukawa, Takeya, Katayama, S, Hayashizaki, Y, Chalk, Alistair M, Katayama, Shintaro, Hume, David A, Chalk, AM, Taylor, Darrin, Kawaji, Hideya, Wells, CA, Waddell, N, Lo, S, Kai, C   +35 more
core   +1 more source