Results 11 to 20 of about 225,548 (263)

Involvement of Toll-Like Receptor 4 in Decreased Vasopressor Response Following Trauma/Hemorrhagic Shock

Critical Care Explorations, 2021
OBJECTIVES:. Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock ...
Rafi Mazor, PhD, Fernando Dos Santos, PhD, Joyce B. Li, MSc, Federico Aletti, PhD, Geert Schmid-Schonbein, PhD, Erik B. Kistler, MD, PhD   +5 more
doaj   +1 more source

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer [PDF]

Immunity, 2009
Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA complexes.
Kang, JY Kang, Jin Young, Nan, X Nan, Xuehua, Jin, MS Jin, Mi Sun, Youn, SJ Youn, Suk-Jun, Ryu, YH Ryu, Young Hee, Mah, S Mah, Shinjee, Han, SH Han, Seung Hyun, Lee, H Lee, Hayyoung, Paik, SG Paik, Sang-Gi, Lee, JO Lee, Jie-Oh   +9 more
openaire   +3 more sources

Distribution of Toll‐like receptor 1 and Toll‐like receptor 2 in human lymphoid tissue [PDF]

Immunology, 2003
SummaryTo determine how distinct receptors of the immune system can contribute to innate immunity, we investigated the pattern of Toll‐like receptor 1 (TLR1) and TLR2 expression in human lymphoid tissue. We found that TLR1 and TLR2 were co‐expressed on cells of the innate immune system, including macrophages and dendritic cells.
Maria-Teresa, Ochoa, Annaliza J, Legaspi, Zena, Hatziris, Paul J, Godowski, Robert L, Modlin, Peter A, Sieling   +5 more
openaire   +2 more sources

AhR Regulates Peptidoglycan-Induced Inflammatory Gene Expression in Human Keratinocytes

Journal of Innate Immunity, 2021
Bacterial peptidoglycan (PGN) stimulates toll-like receptor 2 (TLR2) on the surface of keratinocytes (KCs), triggering signaling pathways that promote an innate immune response.
Lanqi Wang, Binbin Cheng, Qiang Ju, Bryan K. Sun   +3 more
doaj   +1 more source

Pulmonary tuberculosis susceptibility and association with Toll-Like receptor 2 Arg753Gln polymorphism

Journal of Infection in Developing Countries, 2022
Introduction: Tuberculosis has been a concern of healthcare professionals due to the serious threats it poses on public health safety. However, regardless all the efforts, no appropriate goals for immunological diagnosis or tuberculosis treatment were ...
Eman A El-Masry, Ibrahim Taher, Helal F Hetta, Samy S Eldahdouh   +3 more
doaj   +1 more source

The Immunological Changes in the Skin of BALC/c Mice with Disseminated Acanthamoebiasis

Pathogens, 2023
Toll-like receptors (TLR) are involved in the recognition of numerous pathogens, including Acanthamoeba spp. Thanks to this, it is possible for immune cells to recognize microorganisms and trigger the body’s innate immune response.
Agnieszka Wojtkowiak-Giera, Monika Derda, Natalia Łanocha-Arendarczyk, Agnieszka Kolasa, Karolina Kot, Joanna Walczykiewicz, Piotr Solarczyk, Danuta Kosik-Bogacka   +7 more
doaj   +1 more source

TOLL-LIKE RECEPTORS (TLR) 2 AND 4 EXPRESSION OF KERATINOCYTES FROM PATIENTS WITH LOCALIZED AND DISSEMINATED DERMATOPHYTOSIS

Revista do Instituto de Medicina Tropical de São Paulo, 2015
There are few studies on the role of innate immune response in dermatophytosis. An investigation was conducted to define the involvement of Toll-Like Receptors (TLRs) 2 and 4 in localized (LD) and
Cristiane Beatriz de Oliveira, Cídia Vasconcellos, Neusa Y. Sakai-Valente, Mirian Nacagami Sotto, Fernanda Guedes Luiz, Walter Belda JÚNIOR, Maria da Gloria Teixeira de Sousa, Gil Benard, Paulo Ricardo Criado   +8 more
doaj   +1 more source

Decreased Toll-like Receptor (TLR) 2 and 4 Expression in Spermatozoa in Couples with Unexplained Recurrent Spontaneous Abortion (URSA)

Iranian Journal of Allergy, Asthma and Immunology, 2019
Studies have shown that toll-like receptors (TLRs) play some important roles in reproductive processes such as ovulation, spermatogenesis, sperm capacitation, fertilization, and pregnancy to the best of our knowledge, no study has evaluated the ...
Nasrin Sereshki, Alireza Andalib, Ataollah Ghahiri, Ferdos Mehrabian, Roya Sherkat, Abbas Rezaei   +5 more
doaj   +1 more source

Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response

Frontiers in Physiology, 2018
Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells.
Korbinian Bösl, Miriam Giambelluca, Markus Haug, Markus Haug, Marit Bugge, Terje Espevik, Richard K. Kandasamy, Richard K. Kandasamy, Bjarte Bergstrøm, Bjarte Bergstrøm   +9 more
doaj   +1 more source

Toll-Like Receptor 4, But Not Toll-Like Receptor 2, Is a Signaling Receptor for Escherichia and Salmonella Lipopolysaccharides [PDF]

The Journal of Immunology, 2000
Abstract Two members of the mammalian Toll-like receptor (TLR) family, TLR2 and TLR4, have been implicated as receptors mediating cellular activation in response to bacterial LPS. Through the use of mAbs raised against human TLR2 and TLR4, we have conducted studies in human cell lines and whole blood to ascertain the relative ...
R I, Tapping, S, Akashi, K, Miyake, P J, Godowski, P S, Tobias   +4 more
openaire   +2 more sources