Results 11 to 20 of about 460,890 (351)
Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer [PDF]
Immunity, 2009 Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA complexes.
Kang, JY Kang, Jin Young +9 more
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Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration
Cell Reports, 2020 Summary: Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate immune system involved in signal transduction.
Kelly Mulfaul +13 more
doaj +2 more sources
Toll-like receptor 2 and type 2 diabetes
Cellular & Molecular Biology Letters, 2016 Innate immunity plays a crucial role in the pathogenesis of type 2 diabetes and related complications. Since the toll-like receptors (TLRs) are central to innate immunity, it appears that they are important participants in the development and pathogenesis of the disease.
Sepehri, Zahra +3 more
openaire +3 more sources
Targeting Toll-like receptors with soluble Toll-like receptor 2 prevents peritoneal dialysis solution–induced fibrosis [PDF]
Kidney International, 2018 Peritoneal membrane failure due to fibrosis limits the use of peritoneal dialysis (PD). Peritoneal fibrosis may potentially be induced by sterile inflammation caused by ongoing cellular stress due to prolonged exposure to PD solutions (PDS). Effective therapies to prevent this process remain to be developed.
Raby, Anne-Catherine +6 more
openaire +3 more sources
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy
Cell Reports, 2015 Impaired autophagy has been implicated in many neurodegenerative diseases, such as Parkinson’s disease (PD), and might be responsible for deposition of aggregated proteins in neurons. However, little is known about how neuronal autophagy and clearance of
Changyoun Kim +9 more
doaj +2 more sources
Herpesviral infection and Toll-like receptor 2 [PDF]
Protein & Cell, 2012 In the last decade, substantial progress has been made in understanding the molecular mechanisms involved in the initial host responses to viral infections. Herpesviral infections can provoke an inflammatory cytokine response, however, the innate pathogen-sensing mechanisms that transduce the signal for this response are poorly understood.
Ming-sheng, Cai +2 more
openaire +2 more sources
Critical Care Explorations, 2021 OBJECTIVES:. Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock ...
Rafi Mazor, PhD +5 more
doaj +1 more source
Distribution of Toll‐like receptor 1 and Toll‐like receptor 2 in human lymphoid tissue [PDF]
Immunology, 2003 SummaryTo determine how distinct receptors of the immune system can contribute to innate immunity, we investigated the pattern of Toll‐like receptor 1 (TLR1) and TLR2 expression in human lymphoid tissue. We found that TLR1 and TLR2 were co‐expressed on cells of the innate immune system, including macrophages and dendritic cells.
Maria-Teresa, Ochoa +5 more
openaire +2 more sources
AhR Regulates Peptidoglycan-Induced Inflammatory Gene Expression in Human Keratinocytes
Journal of Innate Immunity, 2021 Bacterial peptidoglycan (PGN) stimulates toll-like receptor 2 (TLR2) on the surface of keratinocytes (KCs), triggering signaling pathways that promote an innate immune response.
Lanqi Wang +3 more
doaj +1 more source