Results 31 to 40 of about 460,890 (351)

Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2.

Journal of Immunology, 1999
Invasive infection with Gram-positive and Gram-negative bacteria often results in septic shock and death. The basis for the earliest steps in innate immune response to Gram-positive bacterial infection is poorly understood.
A. Yoshimura, E. Lien, R. Ingalls, E. Tuomanen, R. Dziarski, D. Golenbock   +5 more
semanticscholar   +1 more source

Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis. [PDF]

, 2008
Despite high rates of exposure, only 5-10% of people infected with Mycobacterium tuberculosis will develop active tuberculosis (TB) disease, suggesting a significant role for genetic variation in the human immune response to this infection.
Crevel, R. van, Carine Bonnard, Hazel E E Wong, Sahiratmadja Edhyana, Wong, Hazel EE, Ottenhoff, THM, Nejentsev, S., van de Vosse, Esther, Bonnard, C, Ottenhoff, T.H., Martin L Hibberd, Jeffrey S Szeszko, Ottenhoff Tom H. M., Reinout van Crevel, Balabanova, Yanina, van Crevel Reinout, Nejentsev Sergey, Seielstad, M., Ottenhoff, Tom HM, Tom H M Ottenhoff, van Crevel, Reinout, Sahiratmadja, Edhyana, Wong, H.E., Yanina Balabanova, Szeszko Jeffrey S., Hari Dass, Ranjeeta, Alisjahbana Bachti, Szeszko, Jeffrey S, Edhyana Sahiratmadja, Bonnard, Carine, Bachti Alisjahbana, Szeszko, J.S., Francis Drobniewski, Davila, Sonia, Alisjahbana, B., Hibberd, M.L., Hari Dass, R., Balabanova, Y., Alisjahbana, Bachti, van de Vosse, E, Alisjahbana, B, Bonnard Carine, Hari Dass Ranjeeta, Sonia Davila, Ranjeeta Hari Dass, Nejentsev, S, Szeszko, JS, Nejentsev, Sergey, Davila, S, Sergey Nejentsev, Seielstad Mark, Dass, Ranjeeta Hari, van Crevel, R, Bonnard, C., Dass, RH, Hibberd Martin L., Balabanova Yanina, van de Vosse Esther, Vosse, E. van de, Mark Seielstad, Seielstad, M, Hibberd, ML, Balabanova, Y, Davila, S., Drobniewski, F, Sahiratmadja, E., Davila Sonia, Drobniewski, Francis, Seielstad, Mark, Drobniewski, F., Wong, HEE, Hibberd, Martin L, Sahiratmadja, E, Esther van de Vosse, Wong Hazel E. E., Drobniewski Francis   +75 more
core   +1 more source

Toll-Like Receptor 4, But Not Toll-Like Receptor 2, Is a Signaling Receptor for Escherichia and Salmonella Lipopolysaccharides [PDF]

The Journal of Immunology, 2000
Abstract Two members of the mammalian Toll-like receptor (TLR) family, TLR2 and TLR4, have been implicated as receptors mediating cellular activation in response to bacterial LPS. Through the use of mAbs raised against human TLR2 and TLR4, we have conducted studies in human cell lines and whole blood to ascertain the relative ...
R I, Tapping, S, Akashi, K, Miyake, P J, Godowski, P S, Tobias   +4 more
openaire   +2 more sources

Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2–1 and Prevents Doxorubicin-Induced Ileitis

Frontiers in Immunology, 2018
Dietary carbohydrate fibers are known to prevent immunological diseases common in Western countries such as allergy and asthma but the underlying mechanisms are largely unknown.
N. Sahasrabudhe, M. Beukema, Lingmin Tian, Berit Troost, J. Scholte, E. Bruininx, G. Bruggeman, M. A. van den Berg, A. Scheurink, H. Schols, M. Faas, P. de Vos   +11 more
semanticscholar   +1 more source

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

Science Advances, 2018
Innate immune sensing is essential for the proinflammatory program in cellular senescence. Cellular senescence is a stress response program characterized by a robust cell cycle arrest and the induction of a proinflammatory senescence-associated secretory
P. Hari, F. Millar, Nuria Tarrats, Jodie Birch, A. Quintanilla, Curtis Rink, I. Fernández-Duran, M. Muir, A. Finch, V. Brunton, J. Passos, J. Morton, L. Boulter, J. Acosta   +13 more
semanticscholar   +1 more source

Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma [PDF]

, 2022
Objective:Despite all the recent advancements, larynx cancer has shown no improvement in survival rates. The aim of this study was to investigate the expressions of toll-like receptor (TLR)-2, -3, and -4 genes, and determine any relationships with the ...
Çağlar Eker, İnan, Hakkı Caner, Emine Deniz Gözen, Hakkı Caner İnan, Gözen, Emine Deniz, Eker, Çağlar, Çelebi, Asuman, Asuman Çelebi, Emin Karaman, Karaman, Emin   +9 more
core   +1 more source

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

Molecular Neurodegeneration, 2018
Synucleinopathies of the aging population are an heterogeneous group of neurological disorders that includes Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) and are characterized by the progressive accumulation of α-synuclein in neuronal and
Changyoun Kim, B. Spencer, E. Rockenstein, H. Yamakado, M. Mante, A. Adame, J. Fields, Deborah Masliah, M. Iba, He‐Jin Lee, R. Rissman, Seung-Jae Lee, E. Masliah   +12 more
semanticscholar   +1 more source

A Toll for lupus [PDF]

, 2005
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
Anders, Hans-Joachim, H-J Anders
core   +1 more source

Expression and function of toll-like receptor 2 in vertebrate

Acta Histochemica, 2023
Toll-like receptors (TLRs) are essential for identifying and detecting pathogen-associated molecular patterns (PAMPs) produced by a variety of pathogens, including viruses and bacteria. Since TLR2 is the only TLR capable of creating functional heterodimers with more than two other TLR types, it is very important for vertebrate immunity.
Pergolizzi, Simona, Fumia, Angelo, D'Angelo, Roberta, Mangano, Angelica, Lombardo, Giorgia Pia, Giliberti, Angelo, Messina, Emmanuele, Alesci, Alessio, Lauriano, Eugenia Rita   +8 more
openaire   +2 more sources

K63-Linked Polyubiquitination on TRAF6 Regulates LPS-Mediated MAPK Activation, Cytokine Production, and Bacterial Clearance in Toll-Like Receptor 7/8 Primed Murine Macrophages

Frontiers in Immunology, 2018
Post viral infection bacterial pneumonia is a major cause of morbidity and mortality associated with both seasonal and pandemic influenza virus illness.
Jaya Talreja, Lobelia Samavati, Lobelia Samavati   +2 more
doaj   +1 more source