Results 11 to 20 of about 225,240 (261)

Toll‐like receptor 4 in CNS pathologies [PDF]

Journal of Neurochemistry, 2010
J. Neurochem. (2010) 114, 13–27.AbstractThe responses of the brain to infection, ischemia and trauma share remarkable similarities. These and other conditions of the CNS coordinate an innate immune response marked by activation of microglia, the macrophage‐like cells of the nervous system. An important contributor to microglial activation is toll‐like
Buchanan, M., Hutchinson, M., Watkins, L., Yin, H.   +3 more
openaire   +3 more sources

Immunological study of orthodontically treated patients recovering from COVID-19 in Babylon Province, Iraq

Medical Journal of Babylon, 2023
Background and Objectives: This study aimed to examine the levels of the toll-like receptors TLR4 and TLR2 in the blood and saliva of patients with coronavirus disease-2019 (COVID-19) receiving orthodontic care in Babylon Province. Materials and Methods:
Basma Abdel Khaleq Eidan, Thaer Jaber Al-Khafaji, Ahmed Mohammed Abbas   +2 more
doaj   +1 more source

Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105 [PDF]

Nature Immunology, 2005
Activation of Toll-like receptor (TLR) signaling by microbial signatures is critical to the induction of immune responses. Such responses demand tight regulation. RP105 is a TLR homolog thought to be mostly B cell specific, lacking a signaling domain. We report here that RP105 expression was wide, directly mirroring that of TLR4 on antigen-presenting ...
Senad, Divanovic, Aurelien, Trompette, Sowsan F, Atabani, Rajat, Madan, Douglas T, Golenbock, Alberto, Visintin, Robert W, Finberg, Alexander, Tarakhovsky, Stefanie N, Vogel, Yasmine, Belkaid, Evelyn A, Kurt-Jones, Christopher L, Karp   +11 more
openaire   +2 more sources

Toll-like receptor 4 and atherogenesis

Annals of Medicine, 2003
Toll-like receptor 4 (TLR4) is a pattern recognition receptor involved in the innate immune response to various microorganisms and other exogenous and endogenous stress factors. Recently, evidence emerged that important inflammatory processes implicit in human atherogenesis are mediated in part via the TLR4/nuclear factor-kappaB pathway.
Stefan, Kiechl, Christian J, Wiedermann, Johann, Willeit   +2 more
openaire   +2 more sources

Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells [PDF]

European Journal of Immunology, 2002
Toll-like receptor 4 (TLR4) is the signal-transducing component of the LPS recognition complex and is essential for LPS-induced septic shock. Here we demonstrate that TLR1 has the capacity to abrogate TLR4 signaling. Human microvascular endothelial cells express TLR4 but not TLR1 and respond to LPS through TLR4. The ability of these cells to respond to
Jessica H, Spitzer, Alberto, Visintin, Alessandra, Mazzoni, Margaret N, Kennedy, David M, Segal   +4 more
openaire   +2 more sources

Sequence variants of toll like receptor 4 and late-onset Alzheimer's disease.

PLoS ONE, 2012
BackgroundToll like receptor 4 (TLR4) has been related to inflammation and beta-amyloid deposition in Alzheimer's disease (AD) brain. No study has explored the association between haplotype-tagging single nucleotide polymorphisms (htSNPs) of TLR4 and AD ...
Yen-Ching Chen, Ping-Keung Yip, Yi-Ling Huang, Yu Sun, Li-Li Wen, Yi-Min Chu, Ta-Fu Chen   +6 more
doaj   +1 more source

Toll-like receptor 2 or toll-like receptor 4 deficiency does not modify lupus in MRLlpr mice.

PLoS ONE, 2013
Systemic lupus erythematosus is an autoimmune disease with a high morbidity and nephritis is a common manifestation. Previous studies in murine lupus models have suggest a role for Toll-like receptor 2 and 4.
Simon J Freeley, Angela Giorgini, Calogero Tulone, Reena J Popat, Catherine Horsfield, Michael G Robson   +5 more
doaj   +1 more source

Bacterial flagellin is a dominant, stable innate immune activator in the gastrointestinal contents of mice and rats

Gut Microbes, 2023
Intestinal contents comprise the largest repository of immunogenic ligands of microbial origin. We undertook this study to assess the predominant microbe-associated molecular patterns (MAMPs) present therein and the receptors) that mediate the innate ...
Matam Vijay-Kumar, Venugopal R. Bovilla, Beng San Yeoh, Rachel M. Golonka, Piu Saha, Bina Joe, Andrew T. Gewirtz   +6 more
doaj   +1 more source

Computational Approaches to Toll-Like Receptor 4 Modulation [PDF]

Molecules, 2016
Toll-like receptor 4 (TLR4), along with its accessory protein myeloid differentiation factor 2 (MD-2), builds a heterodimeric complex that specifically recognizes lipopolysaccharides (LPS), which are present on the cell wall of Gram-negative bacteria, activating the innate immune response.
Jean-Marc Billod, Alessandra Lacetera, Joan Guzmán-Caldentey, Sonsoles Martín-Santamaría   +3 more
openaire   +4 more sources

Toll‐like receptor 4 polymorphisms in Saudi population with cardiovascular diseases

Molecular Genetics & Genomic Medicine, 2019
Background Toll‐like receptors play a substantial role in innate immunity and the effects of TLR4 genetic variants on cardiovascular diseases are still largely unknown.
Abdelhabib Semlali, Mikhlid Al Mutairi, Ibrahim Oqla Alanazi, Hasan Awad Aljohi, Narasimha Reddy Parine, Abdullah Alhadheq, Abdulaziz A. Al‐Jafari, Abdulelah F. Mobeirek, Abdullah Al Amri, Jilani P. Shaik, Fatima‐zohra Filali, Mohammad Alanazi   +11 more
doaj   +1 more source