Results 11 to 20 of about 371,093 (352)
EXPRESSION FEATURES OF TOLL-LIKE RECEPTOR 2 AND TOLL-LIKE RECEPTOR 4 IN CHILDREN WITH ASTHMA
Медицинская иммунология, 2017 Currently actively discussed the role of innate immunity receptors, in particular TLRs in the immunopathogenesis of bronchial asthma (BA).The aim of our work was to study the expression of ТLR2 and TLR4 on the nasal mucosal cells and peripheral ...
L. V. Gankovskaya +7 more
doaj +3 more sources
Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. [PDF]
, 2019 We previously reported that the canonical innate immune receptor toll-like receptor 4 (TLR4) is critical in maintaining lung integrity. However, the molecular mechanisms via which TLR4 mediates its effect remained unclear.
Ardito, Taylor +10 more
core +3 more sources
Toll-like receptor-4 modulation for cancer immunotherapy [PDF]
Frontiers in Immunology, 2014 Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition molecules. Since the discovery of the Toll pathway cascade (1, 2), our knowledge about the structure, function, and mechanics of TLRs in infectious and inflammatory conditions has increased remarkably. The role of TLR4 as a pathogen-pattern recognition receptor has been studied
Shanjana eAwasthi
doaj +3 more sources
Accelerated Calvarial Healing in Mice Lacking Toll-Like Receptor 4 [PDF]
, 2012 The bone and immune systems are closely interconnected. The immediate inflammatory response after fracture is known to trigger a healing cascade which plays an important role in bone repair.
Adam A. Kubala +7 more
core +12 more sources
How Toll-like receptors influence Parkinson’s disease in the microbiome–gut–brain axis
Frontiers in Immunology, 2023 Recently, a large number of experimenters have found that the pathogenesis of Parkinson’s disease may be related to the gut microbiome and proposed the microbiome–gut–brain axis.
Ziyi Zhang +4 more
doaj +1 more source
Toll‐like receptor 4 in atherosclerosis [PDF]
Journal of Cellular and Molecular Medicine, 2007 Introduction Toll‐like receptor 4 structure and its functions TLR4 expression in atherosclerotic lesions Endothelial cells Vascular smooth muscle cells (VSMCs) Adventitial fibroblasts Dendritic cells (DCs) Macrophages Role of TLR4 in atherosclerosis TLR4 in early atherosclerotic lesion TLR4 in advanced atherosclerotic lesion TLR4 in plaque rupture ...
Li, Hongli, Sun, Baogui
openaire +2 more sources
Critical Care Explorations, 2021 OBJECTIVES:. Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock ...
Rafi Mazor, PhD +5 more
doaj +1 more source
Role of Toll Like Receptor 4 in Alzheimer’s Disease
Frontiers in Immunology, 2020 Long-term evidence has confirmed the involvement of an inflammatory component in neurodegenerative disorders including Alzheimer’s disease (AD). This view is supported, in part, by data suggesting that selected non-steroidal anti-inflammatory drugs ...
Maria Calvo-Rodriguez +4 more
doaj +1 more source
Efficient of Toll‐Like Receptor 4 Knockout in Mouse Zygotes by CRISPER/Cas9
Novelty in Biomedicine, 2021 Background: Transgenic animals are genetically modified animals to create a specific trait that imitates an indication of pathogenesis in humans.
Delsuz Rezaee +3 more
doaj +1 more source
Toll-like Receptor 4 and Hepatic Fibrogenesis [PDF]
Seminars in Liver Disease, 2010 Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as important regulators of the inflammatory response and a functional link between inflammation and fibrosis in the chronically injured liver.
Jean-Philippe, Pradere +4 more
openaire +2 more sources