Results 11 to 20 of about 88,792,421 (301)
EXPRESSION FEATURES OF TOLL-LIKE RECEPTOR 2 AND TOLL-LIKE RECEPTOR 4 IN CHILDREN WITH ASTHMA
Медицинская иммунология, 2017 Currently actively discussed the role of innate immunity receptors, in particular TLRs in the immunopathogenesis of bronchial asthma (BA).The aim of our work was to study the expression of ТLR2 and TLR4 on the nasal mucosal cells and peripheral ...
L. V. Gankovskaya +7 more
doaj +3 more sources
Toll‐like receptor 4 in CNS pathologies [PDF]
Journal of Neurochemistry, 2010 J. Neurochem. (2010) 114, 13–27.AbstractThe responses of the brain to infection, ischemia and trauma share remarkable similarities. These and other conditions of the CNS coordinate an innate immune response marked by activation of microglia, the macrophage‐like cells of the nervous system. An important contributor to microglial activation is toll‐like
Buchanan, M. +3 more
openaire +4 more sources
Toll-Like Receptor 4 Signaling and Drug Addiction [PDF]
Frontiers in Pharmacology, 2020 The emphasis of neuronal alterations and adaptations have long been the main focus of the studies of the mechanistic underpinnings of drug addiction. Recent studies have begun to appreciate the role of innate immune system, especially toll-like receptor ...
Ruyan Wu, Ruyan Wu, Jun-Xu Li
doaj +3 more sources
Toll-Like Receptor 4 Signaling in the Trabecular Meshwork
Frontiers in Cell and Developmental Biology, 2022 Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets.
Philip Mzyk +4 more
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Toll-like receptor-4 modulation for cancer immunotherapy [PDF]
Frontiers in Immunology, 2014 Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition molecules. Since the discovery of the Toll pathway cascade (1, 2), our knowledge about the structure, function, and mechanics of TLRs in infectious and inflammatory conditions has increased remarkably. The role of TLR4 as a pathogen-pattern recognition receptor has been studied
Shanjana eAwasthi
doaj +3 more sources
Toll‐like receptor 4 in atherosclerosis [PDF]
Journal of Cellular and Molecular Medicine, 2007 Introduction Toll‐like receptor 4 structure and its functions TLR4 expression in atherosclerotic lesions Endothelial cells Vascular smooth muscle cells (VSMCs) Adventitial fibroblasts Dendritic cells (DCs) Macrophages Role of TLR4 in atherosclerosis TLR4 in early atherosclerotic lesion TLR4 in advanced atherosclerotic lesion TLR4 in plaque rupture ...
Li, Hongli, Sun, Baogui
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Toll-like Receptor 4 and Hepatic Fibrogenesis [PDF]
Seminars in Liver Disease, 2010 Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as important regulators of the inflammatory response and a functional link between inflammation and fibrosis in the chronically injured liver.
Jean-Philippe, Pradere +4 more
openaire +2 more sources
A study of the modulation of Toll-like receptor signalling in macrophages by Annexin-1 [PDF]
, 2011 PhDAnnexin-A1 (AnxA1) is an endogenous anti-inflammatory protein that has been shown to exert a protective role against the lethal effects induced by the Toll-like receptor (TLR) 4 agonist lipopolysaccharide (LPS).
Polycarpou, Anastasia
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Toll-like Receptor 4 Polymorphisms and Atherogenesis
New England Journal of Medicine, 2002 The ability to mount a prominent inflammatory response to bacterial pathogens confers an advantage in innate immune defense but may signal an increased risk of atherosclerosis. We determined whether recently discovered genetic variants of toll-like receptor 4 (TLR4) that confer differences in the inflammatory response elicited by bacterial ...
Cooke, G, Segal, S, Hill, A
openaire +5 more sources
Alternate transcription of the Toll-like receptor signaling cascade [PDF]
, 2006 Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr) cascade has been shown to dramatically alter the signaling capacity of inflammatory cells, but it is not known how common this mechanism is. We provide transcriptional evidence
Kai, Chikatoshi +35 more
core +1 more source