Results 1 to 10 of about 19,241 (251)

TLR2 Looks at Lipoproteins [PDF]

Immunity, 2009
Toll-like receptors (TLRs) have evolved to recognize lipoproteins from diverse species of bacteria. In this issue of Immunity, Kang et al. (2009) provide insight into the mechanisms by which TLR2-TLR6 heterodimers recognize diacylated liporoteins ...
Schenk, Mirjam, Belisle, John T, Belisle, John T., Modlin, Robert L, Modlin, Robert L.   +4 more
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Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation [PDF]

BMC Biotechnology, 2010
Background Toll-like receptor (TLR) 2 is a component of the innate immune system and senses specific pathogen associated molecular patterns (PAMPs) of both microbial and viral origin. Cell activation via TLR2 and other pattern recognition receptors (PRRs)
Werner Lindenmaier, Stefan Dreher, Kirschning, Carsten J, Wagner, Hermann, Wagner Hermann, Dreher Stefan, Böldicke, Thomas, Carsten J Kirschning, Schade, Jutta, Köster, Mario, Mario Köster, Thomas Böldicke, Schade Jutta, Lindenmaier, Werner, Kirschning Carsten J, Björn Maaß, Dreher, Stefan, Noack Andreas, Maaß Björn, Böldicke Thomas, Fichte, Sylvia, Lindenmaier Werner, Sylvia Fichte, Köster Mario, Andreas Noack, Fichte Sylvia, Hermann Wagner, Maass, Björn, Jutta Schade, Noack, Andreas   +29 more
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TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors [PDF]

Journal of Leukocyte Biology, 2013
Item does not contain fulltextTLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional TLRs described in humans, TLR2 is unique in its requirement to form heterodimers with TLR1 or TLR6 for the initiation of signaling
Garssen, J., Folkerts, G., Plantinga, T.S., Joosten, L.A.B., Vos, A.P., Netea, M.G., Kraneveld, A.D., Bergenhenegouwen, J. van   +7 more
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MiR-344b-1-3p targets TLR2 and negatively regulates TLR2 signaling pathway

International Journal of Chronic Obstructive Pulmonary Disease, 2017
Hong Xu,1–3,* Yuting Wu,2–4,* Li Li,1–3 Weifeng Yuan,1–3 Deming Zhang,2–4 Qitao Yan,2,3 Zhenhui Guo,2,3 Wenjie Huang1–3 1Department of Respiratory Medicine, 2Guangdong Provincial Key Laboratory of Geriatric ...
Zhang D, Yan Q, Guo Z, Huang W, Xu H, Li L, Yuan W, Wu Y   +7 more
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Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering [PDF]

The Journal of Immunology, 2009
TLR overactivation may lead to end organ damage and serious acute and chronic inflammatory conditions. TLR responses must therefore be tightly regulated to control disease outcomes. We show in this study the ability of the soluble form of TLR2 (sTLR2) to
Raby, Anne-Catherine, Richards, Peter, Labeta, Mario Oscar, Colmont, Chantal Sophie, Le Bouder, Emmanuel, George, Christopher H., Coles, Barbara, Davies, James Anthony, Topley, Nicholas, Jones, Simon Arnett, Brennan, Paul   +10 more
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Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk.

Allergy, 2009
Common genetic variations in toll-like receptor 2 (TLR2), an innate pathogen recognition receptor, may influence the development of atopic diseases. So far, very little is known about the role of rare TLR2 mutations in these diseases. We investigated the
Kabesch, M., Vogelberg, C., Spiller, S., Illig, T., Depner, M., Kormann, M.S.D., Ferstl, R., von Mutius, E., Kirschning, C.J., Klopp, N.   +9 more
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Inhibition of Autoimmune Diabetes by TLR2 Tolerance [PDF]

The Journal of Immunology, 2011
We have reported that apoptotic β cells undergoing secondary necrosis, called “late apoptotic (LA) β cells,” stimulated APCs and induced diabetogenic T cell priming through TLR2, which might be one of the initial events in autoimmune diabetes.
Seung Hoon Oh, June-Chul Lee, Kwang-Won Kim, Do-Hoon Kim, Myung-Shik Lee, Moon-Kyu Lee, Sunshin Kim   +6 more
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TLR2 agonists and their structure-activity relationships.

Organic & Biomolecular Chemistry, 2020
Agonists of Toll-like Receptor 2 (TLR2) are attractive synthetic targets due to their use as adjuvants in immunotherapies to treat various diseases notably, cancer.
Lu, Benjamin, Brimble, Margaret, Williams, Geoffrey M   +2 more
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TLR2 Mediates Immunity to Experimental Cysticercosis [PDF]

International Journal of Biological Sciences, 2011
Information concerning TLR-mediated antigen recognition and regulation of immune responses during helminth infections is scarce. TLR2 is a key molecule required for innate immunity and is involved in the recognition of a wide range of viruses, bacteria ...
José L. Reyes, Marisol I. González, Yadira Ledesma-Soto, Abhay R. Satoskar, Luis I. Terrazas
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Focal Staphylococcus Aureus Septic Arthritis Elicits Age and TLR2-Dependent Periarticular Bone Loss [PDF]

Journal of Inflammation Research
Michelle Schultz,1,* Zhicheng Hu,1,2,* Meghshree Deshmukh,1 Petra Henning,3 Ulf H Lerner,3 Majd Mohammad,1 Tao Jin1,4 1Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg,
Schultz M, Hu Z, Deshmukh M, Henning P, Lerner UH, Mohammad M, Jin T   +6 more
doaj   +1 more source