Results 21 to 30 of about 152,328 (305)
Gut Microbes, 2021 Gut microbiota have myriad roles in host physiology, development, and immunity. Though confined to the intestinal lumen by the epithelia, microbes influence distal systems via poorly characterized mechanisms.
Kevin Champagne-Jorgensen +5 more
doaj +1 more source
Characterization and investigation of single nucleotide polymorphisms and a novel TLR2 mutation in the human TLR2 gene [PDF]
Human Molecular Genetics, 2007 In the innate immune system, TLR2 plays a central role for the response to a wide variety of microbial and endogenous danger signals. A considerable number of genetic polymorphisms within the human TLR2 gene have been reported in non-coding and coding sequences.
Sabine, Merx +4 more
openaire +2 more sources
Serum amyloid A primes microglia for ATP-dependent interleukin-1\u3b2 release [PDF]
, 2018 Acute-phase response is a systemic reaction to environmental/inflammatory insults and involves production of acute-phase proteins, including serum amyloid A (SAA).
A Basu +82 more
core +2 more sources
Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering [PDF]
The Journal of Immunology, 2009 Abstract TLR overactivation may lead to end organ damage and serious acute and chronic inflammatory conditions. TLR responses must therefore be tightly regulated to control disease outcomes. We show in this study the ability of the soluble form of TLR2 (sTLR2) to regulate proinflammatory responses, and demonstrate the mechanisms ...
Anne-Catherine, Raby +10 more
openaire +4 more sources
OncoImmunology, 2018 Chronic inflammation drives the development of colorectal cancer (CRC), where tumor-infiltrating immune cells interact with cancer cells in a dynamic crosstalk.
Yingxin Yu +5 more
doaj +1 more source
Pifu-xingbing zhenliaoxue zazhi, 2021 Objective: To explore the activation of TLR2/c-Jun and NF-κB signaling pathway in human keratinocytes infected by different ecological classifications of dermatophytes.
Zhen SU +6 more
doaj +1 more source
IgA-enhancing effects of membrane vesicles derived from Lactobacillus sakei subsp. sakei NBRC15893 [PDF]
, 2018 Immunoglobulin (Ig) A in the mucus of the intestinal tract plays an important role in preventing the invasion of pathogenic microorganisms and regulating the composition of the gut microbiota.
Katakura Yoshio +7 more
core +2 more sources
EXPRESSION FEATURES OF TOLL-LIKE RECEPTOR 2 AND TOLL-LIKE RECEPTOR 4 IN CHILDREN WITH ASTHMA
Медицинская иммунология, 2017 Currently actively discussed the role of innate immunity receptors, in particular TLRs in the immunopathogenesis of bronchial asthma (BA).The aim of our work was to study the expression of ТLR2 and TLR4 on the nasal mucosal cells and peripheral ...
L. V. Gankovskaya +7 more
doaj +1 more source
Enhanced TLR2 responses in multiple sclerosis [PDF]
Clinical and Experimental Immunology, 2018 Summary The roles of the microbiome and innate immunity in the pathogenesis of multiple sclerosis (MS) remain unclear. We have previously documented abnormally low levels of a microbiome-derived Toll-like receptor (TLR)2-stimulating bacterial lipid in the blood of MS patients and postulated that this is indicative of a deficiency in the ...
M Fujiwara +10 more
openaire +2 more sources
Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women. [PDF]
, 2015 Bacterial vaginosis (BV) is a common vaginal syndrome associated with altered microflora that increases the risk of preterm delivery and acquisition of sexually transmitted diseases.
Bigham, Abigail W +13 more
core +5 more sources