Results 21 to 30 of about 103,839 (247)

Structural and Functional Evidence for the Role of the TLR2 DD Loop in TLR1/TLR2 Heterodimerization and Signaling [PDF]

Journal of Biological Chemistry, 2006
The Toll/Interleukin-1 receptor (TIR) domain of the Toll-like receptors (TLRs) plays an important role in innate host defense signaling. The TIR-TIR platform formed by the dimerization of two TLRs promotes homotypic protein-protein interactions with additional cytoplasmic adapter molecules to form an active signaling complex resulting in the expression
Jitendra K, Gautam, , Ashish, Laurey D, Comeau, Joanna K, Krueger, Michael F, Smith   +4 more
openaire   +2 more sources

Toll-Like Receptor (TLR) 1, 2, and 6 Gene Polymorphisms Support Evidence of Innate Immune Factors in Schizophrenia

Neuropsychiatric Disease and Treatment, 2023
Carlo E Sotelo-Ramírez,1,2 Beatriz Camarena,2 Marco Antonio Sanabrais-Jiménez,2 Julio Uriel Zaragoza-Hoyos,2 Bruno Ordoñez-Martínez,2 Raul I Escamilla-Orozco,3 Beatriz Gómez-González4 1Posgrado en Biología Experimental, Universidad Autónoma Metropolitana-
Sotelo-Ramírez CE, Camarena B, Sanabrais-Jiménez MA, Zaragoza-Hoyos JU, Ordoñez-Martínez B, Escamilla-Orozco RI, Gómez-González B   +6 more
doaj  

Characterization and investigation of single nucleotide polymorphisms and a novel TLR2 mutation in the human TLR2 gene [PDF]

Human Molecular Genetics, 2007
In the innate immune system, TLR2 plays a central role for the response to a wide variety of microbial and endogenous danger signals. A considerable number of genetic polymorphisms within the human TLR2 gene have been reported in non-coding and coding sequences.
Sabine, Merx, Michael, Neumaier, Hermann, Wagner, Carsten J, Kirschning, Parviz, Ahmad-Nejad   +4 more
openaire   +2 more sources

Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering [PDF]

The Journal of Immunology, 2009
Abstract TLR overactivation may lead to end organ damage and serious acute and chronic inflammatory conditions. TLR responses must therefore be tightly regulated to control disease outcomes. We show in this study the ability of the soluble form of TLR2 (sTLR2) to regulate proinflammatory responses, and demonstrate the mechanisms ...
Anne-Catherine, Raby, Emmanuel, Le Bouder, Chantal, Colmont, James, Davies, Peter, Richards, Barbara, Coles, Christopher H, George, Simon A, Jones, Paul, Brennan, Nicholas, Topley, Mario O, Labéta   +10 more
openaire   +4 more sources

Increased Expression of Toll-Like Receptor (TLR) 2 and TLR6 on Peripheral Blood Monocytes by Induction of Staphylococcal Enterotoxin B During Exacerbation of Atopic Dermatitis Patients

Clinical, Cosmetic and Investigational Dermatology, 2023
Fitria Salim,1,2 Hendra Gunawan,3 Oki Suwarsa,3 Endang Sutedja3 1Doctoral Study Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Department of Dermatology and Venereology, Faculty of Medicine, Universitas Syiah Kuala,
Salim F, Gunawan H, Suwarsa O, Sutedja E
doaj  

The association of rs4696480 polymorphism in TLR2 gene and Staphylococcus aureus skin colonization in children with atopic dermatitis

Український журнал Перинатологія і педіатрія, 2022
Topicality. Up to 90% of patients with atopic dermatitis are colonized with S. aureus, with S. aureus predominance being unique to atopic dermatitis. TLR2 play a role in the presentation of S. aureus antigens in a course of atopic dermatits. Purpose -
O.V. Mozyrska
doaj   +1 more source

Enhanced TLR2 responses in multiple sclerosis [PDF]

Clinical and Experimental Immunology, 2018
Summary The roles of the microbiome and innate immunity in the pathogenesis of multiple sclerosis (MS) remain unclear. We have previously documented abnormally low levels of a microbiome-derived Toll-like receptor (TLR)2-stimulating bacterial lipid in the blood of MS patients and postulated that this is indicative of a deficiency in the ...
M Fujiwara, E J Anstadt, B Flynn, K Morse, C Ng, P Paczkowski, J Zhou, S Mackay, N Wasko, F Nichols, R B Clark   +10 more
openaire   +2 more sources

Clostridium scindens promotes gallstone formation by inducing intrahepatic neutrophil extracellular traps through CXCL1 produced by colonic epithelial cells

Microbial Cell
Cholelithiasis is one of the most common diseases of the biliary system. Neutrophil extracellular traps (NETs) in the liver play an important role in accelerating the formation of gallstones. The upstream mechanism of NETs formation remains unclear.
Wenchao Yao, Yuanhang He, Zhihong Xie, Qiang Wang, Yang Chen, Jingjing Yu, Xuxu Liu, Dongbo Xue, Liyi Wang, Chenjun Hao   +9 more
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Hyperexpression of TLR2 and TLR4 in patients with ischemic stroke in acute period of the disease

Медицинская иммунология, 2020
Pathogenesis of ischemic stroke  is actively  involved  in the  system  of innate immunity. Under conditions of cerebral  ischemia, a number of biologically  active  substances are  released  that  interact with innate immunity receptors, in particular ...
L. V. Gankovskaya, L. V. Stakhovskaya, V. V. Grechenko, E. A. Koltsova, O. S. Uvarova, M. D. Demina, T. V. Gromova, O. A. Svitich   +7 more
doaj   +1 more source

Assessment of laboratory indicators of inflammatory, infection and indicators of subclinical atherosclerosis in patients with systemic lupus erythematosus

Научно-практическая ревматология
The aim of the study was to reveal the relationship between the activity of inflammation, the infectious component, platelet function and dyslipidemia, in the development of subclinical atherosclerosis in patients with systemic lupus erythematosus (SLE ...
A. V. Arshinov, N. Yu. Levshin, I. G. Maslova, A. A. Baranov, V. I. Emanuylov   +4 more
doaj   +1 more source