Results 21 to 30 of about 19,241 (251)

Gram-positive bacterial lipoglycans based on a glycosylated diacylglycerol lipid anchor are microbe-associated molecular patterns recognized by TLR2 [PDF]

, 2013
Innate immune recognition is the first line of host defense against invading microorganisms. It is a based on the detection, by pattern recognition receptors (PRRs), of invariant molecular signatures that are unique to microorganisms.
Alain Vercellone, Nigou, Jerome, Iain Sutcliffe, Besra, Gurdyal, Mishra Arun K., Arun K Mishra, Jérôme Nigou, Blanc Landry, Sutcliffe Iain, Mishra, Arun, Gurdyal S Besra, Castanier Romain, Ray, Aurélie, Romain Castanier, Vercellone, Alain, Ray Aurélie, Mishra, Arun K, Castanier, Romain, Landry Blanc, Blanc, Landry, Vercellone Alain, Nigou Jérôme, Besra, Gurdyal S; id_orcid, Sutcliffe, Iain, Besra Gurdyal S., Mishra, Arun K., Aurélie Ray   +26 more
core   +2 more sources

TLR2 Mediates Neuroinflammation and Neuronal Damage [PDF]

The Journal of Immunology, 2007
Abstract Innate immunity relies on pattern recognition receptors to detect the presence of infectious pathogens. In the case of Gram-positive bacteria, binding of bacterial lipopeptides to TLR2 is currently regarded as an important mechanism.
Hoffmann, O., Braun, J., Becker, D., Halle, A., Freyer, D., Dagand, E., Lehnardt, S., Weber, J.   +7 more
openaire   +3 more sources

EXPRESSION FEATURES OF TOLL-LIKE RECEPTOR 2 AND TOLL-LIKE RECEPTOR 4 IN CHILDREN WITH ASTHMA

Медицинская иммунология, 2017
Currently actively  discussed  the  role  of innate immunity receptors, in particular TLRs  in the immunopathogenesis of bronchial asthma (BA).The aim of our work was to study the expression of ТLR2 and TLR4 on the nasal mucosal cells and peripheral ...
L. V. Gankovskaya, L. S. Namazova-Baranova, M. V. Khoreva, B. G. Bragvadze, A. D. Ogurtsova, A. A. Alekseeva, V. А. Gankovskii, O. А. Svitich   +7 more
doaj   +1 more source

Staphylococcus aureus lipoproteins - TLR2-mediated activation of innate and adaptive immunity [PDF]

, 2010
Staphylococcus (S.) aureus is a very successful pathogen due to its immune evasion strategies. Besides toxins and adhesins, it expresses membrane lipoproteins (Lpp), which are bound by the pattern recognition receptor Toll-like receptor (TLR) 2 in the ...
Schmaler, Mathias
core   +1 more source

Sialylation of TLR2 initiates osteoclast fusion [PDF]

Bone Research, 2022
AbstractThe molecular control of osteoclast formation is still not clearly elucidated. Here, we show that a process of cell recognition mediated by Siglec15-TLR2 binding is indispensable and occurs prior to cell fusion in RANKL-mediated osteoclastogenesis. Siglec15 has been shown to regulate osteoclastic bone resorption.
Ce Dou, Gehua Zhen, Yang Dan, Mei Wan, Nathachit Limjunyawong, Xu Cao   +5 more
openaire   +3 more sources

Polymorphism of genes associated with infectious lung diseases in Northern Asian populations and in patients with community-acquired pneumonia

Вавиловский журнал генетики и селекции, 2021
The innate Iнн\mmune system is the first to respond to invading pathogens. It is responsible for invader recognition, immune-cell recruitment, adaptive-immunity activation, and regulation of inflammation intensity.
S. V. Mikhailova, L. V. Shcherbakova, N. I. Logvinenko, I. I. Logvinenko, M. I. Voevoda   +4 more
doaj   +1 more source

Bacterial membrane vesicles and phages in blood after consumption of Lacticaseibacillus rhamnosus JB-1

Gut Microbes, 2021
Gut microbiota have myriad roles in host physiology, development, and immunity. Though confined to the intestinal lumen by the epithelia, microbes influence distal systems via poorly characterized mechanisms.
Kevin Champagne-Jorgensen, Tamina A. Jose, Andrew M. Stanisz, M. Firoz Mian, Alexander P. Hynes, John Bienenstock   +5 more
doaj   +1 more source

TLR2: A Crossroads between Infections and Autoimmunity? [PDF]

International Journal of Immunopathology and Pharmacology, 2011
Environment has both pathogenic and protective roles in the determination of autoimmune disease development, possibly through infectious agents. TLR2 has the capability to recognize the widest range of PAMPs, and it is important for the recognition of mycobacteria and gram-positive bacteria.
Borrello, Silvia, Nicolò, C, Delogu, Giovanni, Pandolfi, Franco, Ria, Francesco   +4 more
openaire   +4 more sources

Neonatal Cystitis Makes Adult Female Rat Urinary Bladders More Sensitive to Low Concentration Microbial Antigens

Research and Reports in Urology, 2023
Ashley C Archer,1 Jennifer J DeBerry,2 Cary DeWitte,2 Timothy J Ness2 1University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA; 2Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham,
Archer AC, DeBerry JJ, DeWitte C, Ness TJ   +3 more
doaj  

Differential induction of TLR2/c-Jun and NF-κB signaling pathway in human keratinocytes infected by Trichophyton rubrum and Microsporum gypseum

Pifu-xingbing zhenliaoxue zazhi, 2021
Objective: To explore the activation of TLR2/c-Jun and NF-κB signaling pathway in human keratinocytes infected by different ecological classifications of dermatophytes.
Zhen SU, Weiwei DENG, Shuting ZHAN, Panpan LIANG, Meirong LI, Songchao YIN, Jian CHEN   +6 more
doaj   +1 more source