Results 11 to 20 of about 152,328 (305)

TLR2 Looks at Lipoproteins [PDF]

Immunity, 2009
Toll-like receptors (TLRs) have evolved to recognize lipoproteins from diverse species of bacteria. In this issue of Immunity, Kang et al. (2009) provide insight into the mechanisms by which TLR2-TLR6 heterodimers recognize diacylated liporoteins, whereas TLR2-TLR1 heterodimers recognize triacylated lipopeptides.
Schenk, Mirjam, Belisle, John T., Modlin, Robert L.   +2 more
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Targeting TLR2 for Vaccine Development [PDF]

Journal of Immunology Research, 2014
Novel and more effective immunization strategies against many animal diseases may profit from the current knowledge on the modulation of specific immunity through stimulation of innate immune receptors. Toll-like receptor (TLR)2-targeting formulations, such as synthetic lipopeptides and antigens expressed in fusion with lipoproteins, have been shown to
Afonso P. Basto, Alexandre Leitão
openaire   +4 more sources

TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors [PDF]

Journal of Leukocyte Biology, 2013
ABSTRACTTLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional TLRs described in humans, TLR2 is unique in its requirement to form heterodimers with TLR1 or TLR6 for the initiation of signaling and cellular activation.
Bergenhenegouwen, J. van, Plantinga, T.S., Joosten, L.A.B., Netea, M.G., Folkerts, G., Kraneveld, A.D., Garssen, J., Vos, A.P.   +7 more
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Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation [PDF]

BMC Biotechnology, 2010
AbstractBackgroundToll-like receptor (TLR) 2 is a component of the innate immune system and senses specific pathogen associated molecular patterns (PAMPs) of both microbial and viral origin. Cell activation via TLR2 and other pattern recognition receptors (PRRs) contributes to sepsis pathology and chronic inflammation both relying on overamplification ...
Kirschning, Carsten Jürgen, Dreher, Stefan, Maaß, Björn, Fichte, Sylvia, Schade, Jutta, Köster, Mario, Noack, Andreas, Lindenmaier, Werner, Wagner, Hermann, Böldicke, Thomas   +9 more
openaire   +4 more sources

Sialylation of TLR2 initiates osteoclast fusion [PDF]

Bone Research, 2022
AbstractThe molecular control of osteoclast formation is still not clearly elucidated. Here, we show that a process of cell recognition mediated by Siglec15-TLR2 binding is indispensable and occurs prior to cell fusion in RANKL-mediated osteoclastogenesis. Siglec15 has been shown to regulate osteoclastic bone resorption.
Ce Dou, Gehua Zhen, Yang Dan, Mei Wan, Nathachit Limjunyawong, Xu Cao   +5 more
openaire   +3 more sources

TLR2 Mediates Neuroinflammation and Neuronal Damage [PDF]

The Journal of Immunology, 2007
Abstract Innate immunity relies on pattern recognition receptors to detect the presence of infectious pathogens. In the case of Gram-positive bacteria, binding of bacterial lipopeptides to TLR2 is currently regarded as an important mechanism.
Hoffmann, O., Braun, J., Becker, D., Halle, A., Freyer, D., Dagand, E., Lehnardt, S., Weber, J.   +7 more
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Immunoregulatory effects triggered by immunobiotic Lactobacillus jensenii TL2937 strain involve efficient phagocytosis in porcine antigen presenting cells [PDF]

, 2016
Background: Immunobiotic Lactobacillus jensenii TL2937 modulates porcine mononuclear phagocytes from Peyer?s patches (PPMPs) and induces a differential production of pro- and anti-inflammatory cytokines in response to Toll-like receptor (TLR)-4 ...
Aso, Hisashi, Iida, Hikaru, Kanmani, Paulraj, Kano, Hiroshi, Kitazawa, Haruki, Makino, Seiya, Nochi, Tomonori, Ohkawara, Sou, Ohwada, Shuichi, Saito, Tadao, Suda, Yoshihito, Takahashi, Takuya, Tsukida, Kohichiro, Villena, Julio Cesar   +13 more
core   +1 more source

Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. [PDF]

, 2013
BackgroundSpinal Toll-like receptors (TLRs) and signaling intermediaries have been implicated in persistent pain states. We examined the roles of two major TLR signaling pathways and selected TLRs in a mononeuropathic allodynia.MethodsL5 spinal nerve ...
A Ledeboer, AI de la Llave-Rincon, AL Oaklander, AS Jaggi, BJ Marsh, C Erridge, C Fernandez-de-las-Penas, C Fernandez-de-las-Penas, CA Christianson, CC Bowman, CF Kim, CI Svensson, CR Stewart, CS Jack, D Kim, D Kim, F Kozin, F Marchand, FY Tanga, H Cao, H Hacker, H Hashizume, H Tsujino, H Yanai, I Bettoni, J Mika, J Zhang, JA DeLeo, JA Stokes, JA Stokes, Jennifer A Stokes, JL Hylden, JM Chung, Jonathan Cheung, K Hoebe, K Honda, K Hoshino, K Kariko, KA Cavassani, Kelly Eddinger, KH Konopka, L Cao, L Nicotra, L Znaor, LA O’Neill, LA Panagio, LH Guo, M Bsibsi, M Calvo, M Chacur, M Hossaini, M Koltzenburg, M Yamamoto, Maripat Corr, MR Hutchinson, MR Hutchinson, NE Saade, O Adachi, O Saito, O Takeuchi, P Hu, P Hu, Q Xu, Q Zhang, R Wang, RE Sorge, RG Chen, RG Zanon, S Akira, S Akira, S Hosmane, S Lehnardt, S Nadeau, S Pu, S Rivest, S Sakaguchi, SR Chaplan, SW Mitchell, T Kawai, T King, T Liu, T Shichita, T Tanaka, Tony L Yaksh, TW Vanderah, V Huge, V Raghavendra, V Raghavendra, XY Hua, Y Ohmichi, YR Wen   +90 more
core   +1 more source

Polymorphism of genes associated with infectious lung diseases in Northern Asian populations and in patients with community-acquired pneumonia

Вавиловский журнал генетики и селекции, 2021
The innate Iнн\mmune system is the first to respond to invading pathogens. It is responsible for invader recognition, immune-cell recruitment, adaptive-immunity activation, and regulation of inflammation intensity.
S. V. Mikhailova, L. V. Shcherbakova, N. I. Logvinenko, I. I. Logvinenko, M. I. Voevoda   +4 more
doaj   +1 more source

Structural and Functional Evidence for the Role of the TLR2 DD Loop in TLR1/TLR2 Heterodimerization and Signaling [PDF]

Journal of Biological Chemistry, 2006
The Toll/Interleukin-1 receptor (TIR) domain of the Toll-like receptors (TLRs) plays an important role in innate host defense signaling. The TIR-TIR platform formed by the dimerization of two TLRs promotes homotypic protein-protein interactions with additional cytoplasmic adapter molecules to form an active signaling complex resulting in the expression
Jitendra K, Gautam, , Ashish, Laurey D, Comeau, Joanna K, Krueger, Michael F, Smith   +4 more
openaire   +2 more sources