Results 11 to 20 of about 103,839 (247)
TLR2 Looks at Lipoproteins [PDF]
Immunity, 2009 Toll-like receptors (TLRs) have evolved to recognize lipoproteins from diverse species of bacteria. In this issue of Immunity, Kang et al. (2009) provide insight into the mechanisms by which TLR2-TLR6 heterodimers recognize diacylated liporoteins, whereas TLR2-TLR1 heterodimers recognize triacylated lipopeptides.
Schenk, Mirjam +2 more
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TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors [PDF]
Journal of Leukocyte Biology, 2013 ABSTRACTTLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional TLRs described in humans, TLR2 is unique in its requirement to form heterodimers with TLR1 or TLR6 for the initiation of signaling and cellular activation.
Bergenhenegouwen, J. van +7 more
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Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation [PDF]
BMC Biotechnology, 2010 AbstractBackgroundToll-like receptor (TLR) 2 is a component of the innate immune system and senses specific pathogen associated molecular patterns (PAMPs) of both microbial and viral origin. Cell activation via TLR2 and other pattern recognition receptors (PRRs) contributes to sepsis pathology and chronic inflammation both relying on overamplification ...
Kirschning, Carsten Jürgen +9 more
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Targeting TLR2 for Vaccine Development [PDF]
Journal of Immunology Research, 2014 Novel and more effective immunization strategies against many animal diseases may profit from the current knowledge on the modulation of specific immunity through stimulation of innate immune receptors. Toll-like receptor (TLR)2-targeting formulations, such as synthetic lipopeptides and antigens expressed in fusion with lipoproteins, have been shown to
Afonso P. Basto, Alexandre Leitão
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TLR2 Mediates Neuroinflammation and Neuronal Damage [PDF]
The Journal of Immunology, 2007 Abstract Innate immunity relies on pattern recognition receptors to detect the presence of infectious pathogens. In the case of Gram-positive bacteria, binding of bacterial lipopeptides to TLR2 is currently regarded as an important mechanism.
Hoffmann, O. +7 more
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Sialylation of TLR2 initiates osteoclast fusion [PDF]
Bone Research, 2022 AbstractThe molecular control of osteoclast formation is still not clearly elucidated. Here, we show that a process of cell recognition mediated by Siglec15-TLR2 binding is indispensable and occurs prior to cell fusion in RANKL-mediated osteoclastogenesis. Siglec15 has been shown to regulate osteoclastic bone resorption.
Ce Dou +5 more
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TLR2: A Crossroads between Infections and Autoimmunity? [PDF]
International Journal of Immunopathology and Pharmacology, 2011 Environment has both pathogenic and protective roles in the determination of autoimmune disease development, possibly through infectious agents. TLR2 has the capability to recognize the widest range of PAMPs, and it is important for the recognition of mycobacteria and gram-positive bacteria.
Borrello, Silvia +4 more
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Gut Microbes, 2021 Gut microbiota have myriad roles in host physiology, development, and immunity. Though confined to the intestinal lumen by the epithelia, microbes influence distal systems via poorly characterized mechanisms.
Kevin Champagne-Jorgensen +5 more
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Research and Reports in Urology, 2023 Ashley C Archer,1 Jennifer J DeBerry,2 Cary DeWitte,2 Timothy J Ness2 1University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA; 2Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham,
Archer AC +3 more
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Pifu-xingbing zhenliaoxue zazhi, 2021 Objective: To explore the activation of TLR2/c-Jun and NF-κB signaling pathway in human keratinocytes infected by different ecological classifications of dermatophytes.
Zhen SU +6 more
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