Results 1 to 10 of about 10,412 (198)
Current Oncology, 2023 Most so-called “beneficial bacteria” in gut microbiota are Gram-positive, and TLR6 recognizes the peptidoglycan (PGN) present in their cell walls. We hypothesized that a high TLR6 expression status predicts a more favorable prognosis after esophagectomy.
Yusuke Sato, Eri Maeda, Kyoko Nomura
exaly +4 more sources
A 192 bp ERV fragment insertion in the first intron of porcine TLR6 may act as an enhancer associated with the increased expressions of TLR6 and TLR1 [PDF]
Mobile DNA, 2021 Background Toll-like receptors (TLRs) play important roles in building innate immune and inducing adaptive immune responses. Associations of the TLR genes polymorphisms with disease susceptibility, which are the basis of molecular breeding for disease ...
XiaoYan Wang +9 more
doaj +4 more sources
TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides [PDF]
Journal of Biological Chemistry, 2006 Bacterial cell walls contain lipoproteins/peptides, which are strong modulators of the innate immune system. Triacylated lipopeptides are assumed to be recognized by TLR2/TLR1-, whereas diacylated lipopeptides use TLR2/TLR6 heteromers for signaling. Following our initial discovery of TLR6-independent diacylated lipopeptides, we could now characterize ...
Shizuo Akira +2 more
exaly +5 more sources
BacSp222 bacteriocin as a novel ligand for TLR2/TLR6 heterodimer [PDF]
Inflammation Research, 2023 Abstract Objective and design BacSp222 bacteriocin is a bactericidal and proinflammatory peptide stimulating immune cells to produce selected cytokines and NO in NF-ĸB dependent manner. This study aims to identify the receptor which mediates this activity.
Renata Mezyk-Kopec +2 more
exaly +5 more sources
Activation of TLR2 and TLR6 by Dengue NS1 Protein and Its Implications in the Immunopathogenesis of Dengue Virus Infection [PDF]
PLoS Pathogens, 2015 Dengue virus (DV) infection is the most prevalent mosquito-borne viral disease and its manifestation has been shown to be contributed in part by the host immune responses. In this study, pathogen recognition receptors, Toll-like receptor (TLR) 2 and TLR6
Justin Jang Hann Chu
exaly +3 more sources
Gene conversion limits divergence of mammalian TLR1 and TLR6 [PDF]
BMC Evolutionary Biology, 2007 Background Toll-like receptors (TLR) recognize pathogen-associated molecular patterns and are important mediators of the innate immune system. TLR1 and TLR6 are paralogs and located in tandem on the same chromosome in mammals. They form heterodimers with
Dunoyer-Geindre Sylvie +4 more
doaj +5 more sources
Mycobacterial Infection in TLR2 and TLR6 Knockout Mice [PDF]
Microbiology and Immunology, 2003 AbstractTo investigate the role of TLR in the development of murine tuberculosis in vivo, TLR2 and TLR6 knockout (KO) mice were infected with Mycobacterium tuberculosis by placing them in the exposure chamber of an airborne infection apparatus. Both TLR2 and TLR6 KO mice survived until sacrifice at 12 weeks after infection.
Shizuo Akira +2 more
exaly +3 more sources
Evolutionary Response Patterns of the Rodent <i>TLR</i> Genes to Climatic Factors. [PDF]
Ecol EvolThis study systematically investigates the associations between climatic factors and the evolutionary dynamics of Toll‐like receptor (TLR) genes across 42 rodent species. Our findings demonstrate that temperature‐related climatic variables (Annual Mean Temperature, Mean Diurnal Range, and Max Temperature of Warmest Month) may modulate the evolutionary ...
Zhao C +6 more
europepmc +2 more sources
A TLR6 polymorphism is associated with increased risk of Legionnaires’ disease [PDF]
Genes and Immunity, 2013 Legionella pneumophila (Lp), the etiologic agent of Legionnaires' disease (LD), is an important cause of community-acquired and nosocomial pneumonia. However, the host immune and genetic determinants of human susceptibility to Lp are poorly understood. Here we show that both TLR6 and TLR1 cooperate with TLR2 to recognize Lp in transfected HEK293 cells.
Annelies Verbon, S J Skerrett
exaly +5 more sources
Toll-like Receptor Expression Patterns in the Female Reproductive Tract of Sheep [PDF]
AnimalsToll-like receptors (TLRs) play crucial roles in innate immunity, but their function in reproduction remains poorly understood. This study investigated the expression patterns and localization of TLR1-9 in the reproductive system of Hu sheep and their ...
Zhibo Wang +8 more
doaj +2 more sources