Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration [PDF]
Journal of Biological Chemistry, 2017 Recently, a single study revealed a new complex composed of Toll-like receptor 4 (TLR4), TLR6, and CD36 induced by fibrillary Aβ peptides, the hallmark of Alzheimer's disease. Unlike TLRs located on the plasma membrane that dimerize on the membrane after
Ziv Porat, Yechiel Shai
exaly +4 more sources
Identification of TLR2/TLR6 signalling lactic acid bacteria for supporting immune regulation [PDF]
Scientific Reports, 2016 Although many lactic acid bacteria (LAB) influence the consumer’s immune status it is not completely understood how this is established. Bacteria-host interactions between bacterial cell-wall components and toll-like receptors (TLRs) have been suggested ...
Qiuxiang Zhang, Hao Zhang, Paul De Vos
exaly +5 more sources
Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists [PDF]
Journal of Lipid Research, 2012 Atherosclerosis is a chronic inflammatory vascular disease. Toll-like receptors (TLRs) are major initiators of inflammation. TLR2 promotes atherosclerosis in LDL receptor (LDLr)-deficient mice fed a high-fat diet (HFD).
Linda K. Curtiss +3 more
exaly +5 more sources
BacSp222 bacteriocin as a novel ligand for TLR2/TLR6 heterodimer
Inflammation Research, 2023 Objective and design BacSp222 bacteriocin is a bactericidal and proinflammatory peptide stimulating immune cells to produce selected cytokines and NO in NF-ĸB dependent manner.
Justyna Śmiałek-Bartyzel +4 more
semanticscholar +4 more sources
Investigating the link between miR-34a-5p and TLR6 signaling in sepsis-induced ARDS
3 Biotech, 2023 Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are lung complications diagnosed by impaired gaseous exchanges leading to mortality. From the diverse etiologies, sepsis is a prominent contributor to ALI/ARDS. In the present study, we retrieved sepsis-induced ARDS mRNA expression profile and identified 883 differentially expressed ...
Kalaiarasan Ponnusamy +2 more
exaly +4 more sources
Gene conversion limits divergence of mammalian TLR1 and TLR6 [PDF]
BMC Evolutionary Biology, 2007 Background Toll-like receptors (TLR) recognize pathogen-associated molecular patterns and are important mediators of the innate immune system. TLR1 and TLR6 are paralogs and located in tandem on the same chromosome in mammals. They form heterodimers with
Dunoyer-Geindre Sylvie +4 more
doaj +4 more sources
Hypoxia Inducible Factor (HIF)-1 Coordinates Induction of Toll-Like Receptors TLR2 and TLR6 during Hypoxia [PDF]
PLoS ONE, 2007 During acute infection and inflammation, dramatic shifts in tissue metabolism are typical, thereby resulting in profound tissue hypoxia. Therefore, we pursued the hypothesis, that tissue hypoxia may influence innate immune responses by transcriptional ...
Julia-Stefanie Frick, Peter Rosenberger
exaly +2 more sources
Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6
Gastric CancerHelicobacter pylori (H. pylori, Hp) has been designated a class I carcinogen and is closely associated with severe gastric diseases. During colonization in the gastric mucosa, H. pylori develops immune escape by inducing host immune tolerance.
Xiulin Zhang +17 more
semanticscholar +4 more sources
Identification and experimental validation of biomarkers associated with macrophages in myocardial ischemia-reperfusion injury [PDF]
Scientific ReportsMyocardial ischemia-reperfusion injury (MIRI) is a complex process leading to substantial myocardial damage. Macrophages play a pivotal role in tissue development and homeostasis.
Xiaojie Jiang +3 more
doaj +2 more sources
The effect of combination therapy on Bevacizumab, Carmustine, and Metformin chemotherapy drugs on the fluctuating performance expression of TLR2, TLR6, and IL-6 genes in the cell line of brain glioblastoma [PDF]
Cancer Cell InternationalObjective Glioblastoma, one of the most aggressive brain tumors, is distinguished by its resistance to standard treatments. So, studying practical therapeutic methods is of great importance.
Seyedeh Elham Norollahi +10 more
doaj +2 more sources