Results 21 to 30 of about 9,070 (169)

Role of cytokine and Toll-like receptor genes in pathogenesis of inborn heart disease

Медицинская иммунология, 2022
Sporadic congenital heart disease (CHD) may result from immune disorders in the mother – embryo system and/or constitutional disorders in regulatory systems, including those associated with TLR receptors, cytokines and their receptors.
A. V. Shabaldin, A. V. Sinitskaya, S. A. Shmulevich   +2 more
doaj   +1 more source

Identification of microRNAs that regulate TLR2-mediated trophoblast apoptosis and inhibition of IL-6 mRNA. [PDF]

PLoS ONE, 2013
While infection-induced placental inflammation is a common mechanism of adverse pregnancy outcome, some pathogens can also trigger placental apoptosis, and Toll-like receptors (TLRs) mediate this response.
Manish Garg, Julie A Potter, Vikki M Abrahams   +2 more
doaj   +1 more source

Association of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazon

Scientific Reports, 2022
Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in children in childhood. Single-nucleotide polymorphism (SNPs) in key molecules of the immune system, such as Toll-like receptors (TLRs) and CD14 molecules, are associated with
Lilyane Amorim Xabregas, Fabíola Silva Alves Hanna, Fábio Magalhães-Gama, Gláucia Lima Souza, Daniele Sá Pereira, Amanda Barros de Lima, Diana Mota Toro, Mirian Rodrigues Ribeiro Santiago, Leny Nascimento da Motta Passos, Andréa Monteiro Tarragô, Adriana Malheiro, Allyson Guimarães Costa   +11 more
doaj   +1 more source

Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease. [PDF]

PLoS ONE, 2007
Tuberculosis (TB) is the leading cause of death worldwide due to an infectious agent. Data have accumulated over decades suggesting that variability in human susceptibility to TB disease has a genetic component. Toll-like receptors (TLRs) play a critical
Xin Ma, Yuhua Liu, Brian B Gowen, Edward A Graviss, Andrew G Clark, James M Musser   +5 more
doaj   +1 more source

The Toll-Like Receptor 2 Ligand Pam2CSK4 Activates Platelet Nuclear Factor-κB and Bruton’s Tyrosine Kinase Signaling to Promote Platelet-Endothelial Cell Interactions

Frontiers in Immunology, 2021
Circulating platelets establish a variety of immunological programs and orchestrate inflammatory responses at the endothelium. Platelets express the innate immunity family of Toll-like receptors (TLRs).
Iván Parra-Izquierdo, Iván Parra-Izquierdo, Hari Hara Sudhan Lakshmanan, Alexander R. Melrose, Jiaqing Pang, Tony J. Zheng, Kelley R. Jordan, Stéphanie E. Reitsma, Owen J. T. McCarty, Owen J. T. McCarty, Joseph E. Aslan, Joseph E. Aslan, Joseph E. Aslan   +12 more
doaj   +1 more source

Toll-Like Receptor (TLR) 1, 2, and 6 Gene Polymorphisms Support Evidence of Innate Immune Factors in Schizophrenia

Neuropsychiatric Disease and Treatment, 2023
Carlo E Sotelo-Ramírez,1,2 Beatriz Camarena,2 Marco Antonio Sanabrais-Jiménez,2 Julio Uriel Zaragoza-Hoyos,2 Bruno Ordoñez-Martínez,2 Raul I Escamilla-Orozco,3 Beatriz Gómez-González4 1Posgrado en Biología Experimental, Universidad Autónoma Metropolitana-
Sotelo-Ramírez CE, Camarena B, Sanabrais-Jiménez MA, Zaragoza-Hoyos JU, Ordoñez-Martínez B, Escamilla-Orozco RI, Gómez-González B   +6 more
doaj  

Synergic activation of toll-like receptor (TLR) 2/6 and 9 in response to Ureaplasma parvum & urealyticum in human amniotic epithelial cells. [PDF]

PLoS ONE, 2013
Ureaplasma species are the most frequently isolated microorganisms inside the amniotic cavity and have been associated with spontaneous abortion, chorioamnionitis, premature rupture of the membranes (PROM), preterm labour (PL) pneumonia in neonates and ...
Martha Triantafilou, Benjamin De Glanville, Ali F Aboklaish, O Brad Spiller, Sailesh Kotecha, Kathy Triantafilou   +5 more
doaj   +1 more source

The molecular basis for recognition of bacterial ligands at equine TLR2, TLR1 and TLR6 [PDF]

Veterinary Research, 2013
Abstract TLR2 recognises bacterial lipopeptides and lipoteichoic acid, and forms heterodimers with TLR1 or TLR6. TLR2 is relatively well characterised in mice and humans, with published crystal structures of human TLR2/1/Pam3CSK4 and murine TLR2/6/Pam2CSK4. Equine TLR4 is activated by a different panel of ligands to human and murine TLR4, but
Irvine, Katherine, Hopkins, Lee, Gangloff, Monique, Bryant, Clare   +3 more
openaire   +2 more sources

Increased Expression of Toll-Like Receptor (TLR) 2 and TLR6 on Peripheral Blood Monocytes by Induction of Staphylococcal Enterotoxin B During Exacerbation of Atopic Dermatitis Patients

Clinical, Cosmetic and Investigational Dermatology, 2023
Fitria Salim,1,2 Hendra Gunawan,3 Oki Suwarsa,3 Endang Sutedja3 1Doctoral Study Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Department of Dermatology and Venereology, Faculty of Medicine, Universitas Syiah Kuala,
Salim F, Gunawan H, Suwarsa O, Sutedja E
doaj  

Whole genome sequencing of an African American family highlights toll like receptor 6 variants in Kawasaki disease susceptibility.

PLoS ONE, 2017
Kawasaki disease (KD) is the most common acquired pediatric heart disease. We analyzed Whole Genome Sequences (WGS) from a 6-member African American family in which KD affected two of four children.
Jihoon Kim, Chisato Shimizu, Stephen F Kingsmore, Stephen F Kingsmore, Narayanan Veeraraghavan, Eric Levy, Andre M Ribeiro Dos Santos, Hai Yang, Jay Flatley, Long Truong Hoang, Martin L Hibberd, Adriana H Tremoulet, Olivier Harismendy, Lucila Ohno-Machado, Jane C Burns   +14 more
doaj   +1 more source