Results 21 to 30 of about 10,412 (198)

Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and Candida albicans elimination [PDF]

Gut Pathogens, 2017
Toll-like receptors (TLRs) are the major pattern recognition receptors that mediate sensing of a wide range of microorganisms. TLR2 forms heterodimers with either TLR1 or TLR6, broadening its ligand diversity against pathogens. TLR1, TLR2 and TLR6 have been implicated in the recognition of Candida albicans, an opportunistic fungal pathogen that ...
Choteau, Laura, Vancraeyneste, Hélène, Le Roy, Didier, Dubuquoy, Laurent, Romani, Luigina, Jouault, Thierry, Poulain, Daniel, Sendid, Boualem, Calandra, Thierry, Roger, Thierry, Jawhara, Samir   +10 more
openaire   +8 more sources

Innate Immunity Toll‐Like Triad TLR6‐1‐10 and Its Diversity in Distinct Horse Breeds [PDF]

Veterinary Medicine and Science
Toll‐like receptors (TLRs) play important roles in innate immunity and developmental processes. Due to their nature as molecular pattern recognition receptors, their genetic diversity may reflect the effects of various pathogen pressures.
Karla Stejskalova, Leona Vychodilova, Eva Janova, Jan Oppelt, Petr Horin   +4 more
doaj   +2 more sources

Development of N-Acetylated Dipalmitoyl-S-Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists

Molecules, 2019
Cancer vaccine is a promising immunotherapeutic approach to train the immune system with vaccines to recognize and eliminate tumors. Adjuvants are compounds that are necessary in cancer vaccines to mimic an infection process and amplify immune responses.
Yang Zhou, Abid H. Banday, Victor J. Hruby, Minying Cai   +3 more
doaj   +2 more sources

An 192 bp ERV Insertion in the First Intron of TLR6 Acts as an Enhancer to Increase TLR6 and TLR1 Expression [PDF]

, 2020
Abstract BackgroundToll-like receptors (TLRs) play important roles in building innate immune and inducing adaptive immune responses. Associations of the TLR gene polymorphisms with diseases susceptibility, which are the basis of molecular breeding for disease resistant animals, have been reported extensively.
xiaoyan wang, Zixuan Chen, Eduard Murani, Enrico D'alessandro, Yalong An, Cai Chen, Kui Li, Grazia Galeano, Klaus Wimmers, Chengyi Song   +9 more
openaire   +4 more sources

Human genetic diversity regulating the TLR10/TLR1/TLR6 locus confers increased cytokines in response to Chlamydia trachomatis

HGG Advances, 2022
Summary: Human genetic diversity can have profound effects on health outcomes upon exposure to infectious agents. For infections with Chlamydia trachomatis (C.
Alyson B. Barnes, Rachel M. Keener, Benjamin H. Schott, Liuyang Wang, Raphael H. Valdivia, Dennis C. Ko   +5 more
doaj   +1 more source

TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes. [PDF]

PLoS ONE, 2011
After infection with Borrelia species, the risk for developing Lyme disease varies significantly between individuals. Recognition of Borrelia by the immune system is mediated by pattern recognition receptors (PRRs), such as TLRs.
Marije Oosting, Hadewych Ter Hofstede, Patrick Sturm, Gosse J Adema, Bart-Jan Kullberg, Jos W M van der Meer, Mihai G Netea, Leo A B Joosten   +7 more
doaj   +1 more source

TLR6 Modulates First Trimester Trophoblast Responses to Peptidoglycan [PDF]

The Journal of Immunology, 2008
Abstract Intrauterine bacterial infections are a well-established cause of pregnancy complications. One key observation in a number of abnormal pregnancies is that placental apoptosis is significantly elevated. First trimester trophoblast cells are known to express TLR1 and TLR2 and to undergo apoptosis following exposure to Gram ...
Vikki M, Abrahams, Paulomi B, Aldo, Shaun P, Murphy, Irene, Visintin, Kaori, Koga, Gabriella, Wilson, Roberto, Romero, Surendra, Sharma, Gil, Mor   +8 more
openaire   +2 more sources

Aberrant DNA methylation of the toll-like receptors 2 and 6 genes in patients with obstructive sleep apnea.

PLoS ONE, 2020
Obstructive sleep apnea (OSA) is a syndrome leading to chronic intermittent hypoxia, and the up-regulation of toll-like receptors (TLR) 2 and 6 on peripheral blood cells has been reported.
Kuo-Tung Huang, Yung-Che Chen, Chia-Cheng Tseng, Huang-Chih Chang, Mao-Chang Su, Ting-Ya Wang, Yong-Yong Lin, Yi-Xin Zheng, Jen-Chieh Chang, Chien-Hung Chin, Chang-Chun Hsiao, Meng-Chih Lin   +11 more
doaj   +1 more source

Role of cytokine and Toll-like receptor genes in pathogenesis of inborn heart disease

Медицинская иммунология, 2022
Sporadic congenital heart disease (CHD) may result from immune disorders in the mother – embryo system and/or constitutional disorders in regulatory systems, including those associated with TLR receptors, cytokines and their receptors.
A. V. Shabaldin, A. V. Sinitskaya, S. A. Shmulevich   +2 more
doaj   +1 more source

Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists

Journal of Lipid Research, 2012
Atherosclerosis is a chronic inflammatory vascular disease. Toll-like receptors (TLRs) are major initiators of inflammation. TLR2 promotes atherosclerosis in LDL receptor (LDLr)-deficient mice fed a high-fat diet (HFD).
Linda K. Curtiss, Audrey S. Black, David J. Bonnet, Peter S. Tobias   +3 more
doaj   +1 more source