Results 1 to 10 of about 14,758,329 (299)

Toll-like receptor 6 inhibits colorectal cancer progression by suppressing NF-κB signaling [PDF]

Heliyon
Background: Toll-like receptors (TLRs) are implicated in the pathogenesis and progression of inflammation-associated cancers, except their role in regulating innate immunity.
Lina Ma, Yancun Yin, Zhenhai Yu, Ning Xu, Lianhuan Ma, Weiwei Qiao, Xiaowen Zhen, Fan Yang, Naili Zhang, Yue Yu   +9 more
doaj   +4 more sources

Whole genome sequencing of an African American family highlights toll like receptor 6 variants in Kawasaki disease susceptibility. [PDF]

PLoS ONE, 2017
Kawasaki disease (KD) is the most common acquired pediatric heart disease. We analyzed Whole Genome Sequences (WGS) from a 6-member African American family in which KD affected two of four children.
Jihoon Kim, Chisato Shimizu, Stephen F Kingsmore, Stephen F Kingsmore, Narayanan Veeraraghavan, Eric Levy, Andre M Ribeiro Dos Santos, Hai Yang, Jay Flatley, Long Truong Hoang, Martin L Hibberd, Adriana H Tremoulet, Olivier Harismendy, Lucila Ohno-Machado, Jane C Burns   +14 more
doaj   +2 more sources

Human herpesvirus 6 infection impairs Toll-like receptor signaling [PDF]

Virology Journal, 2010
Human herpesvirus 6 (HHV-6) has a tropism for immunocompetent cells, including T lymphocytes, monocytes/macrophages, and dendritic cells (DCs) suggesting that HHV-6 infection affects the immunosurveillance system. Toll-like receptor (TLR) system plays an
Ochi Toshiki, Suemori Koichiro, An Jun, Fujiwara Hiroshi, Tanimoto Kazushi, Murakami Yuichi, Hasegawa Hitoshi, Yasukawa Masaki   +7 more
doaj   +3 more sources

Clostridium butyricum Helps to Alleviate Inflammation in Weaned Piglets Challenged With Enterotoxigenic Escherichia coli K88

Frontiers in Veterinary Science, 2021
Background: Whether the probiotic Clostridium butyricum (CB) alleviates enterotoxigenic Escherichia coli (ETEC) K88-induced inflammation by regulating the activation of the toll-like receptor (TLR) signaling pathway is not clear, thus, we carried out ...
Haihua Li, Xuejiao Liu, Zhiyuan Shang, Jiayun Qiao   +3 more
doaj   +1 more source

Hyperreactivity of Blood Leukocytes in Patients with NAFLD to Ex Vivo Lipopolysaccharide Treatment Is Modulated by Metformin and Phosphatidylcholine but Not by Alpha Ketoglutarate. [PDF]

PLoS ONE, 2015
Toll-like receptor 4 and proinflammatory cytokines play a central role in the progression of nonalcoholic fatty liver disease. We investigated IL-1, IL-6 and TNFα production and toll-like receptor 4 in both--obese and lean patients with non-alcoholic ...
Agnieszka Zwolak, Agnieszka Szuster-Ciesielska, Jadwiga Daniluk, Olga Słabczyńska, Martyna Kandefer-Szerszeń   +4 more
doaj   +1 more source

Patterns of Toll-Like Receptor Expressions and Inflammatory Cytokine Levels and Their Implications in the Progress of Insulin Resistance and Diabetic Nephropathy in Type 2 Diabetic Patients

Frontiers in Physiology, 2020
Background: Diabetic nephropathy (DNP) is a type 2 diabetes mellitus (T2DM) chronic complication, which is the largest single cause of end-stage kidney disease. There is an increasing evidence of the role of inflammation and Toll-like receptors (TLRs) as
Rofyda H. Aly, Amr E. Ahmed, Walaa G. Hozayen, Alaa Mohamed Rabea, Tarek M. Ali, Tarek M. Ali, Ahmad El Askary, Ahmad El Askary, Osama M. Ahmed   +8 more
doaj   +1 more source

Mycobacterium lepraemurium uses tlr-6 and mr, but not lipid rafts or dc-sign, to gain access into mouse macrophages

International Journal of Mycobacteriology, 2017
Objective/Background: Mycobacterium lepraemurium (MLM), the etiologic agent of murine leprosy, is an intracellular parasite of macrophages; the mechanism used by this bacterium to enter macrophages is not known.
Mayra Silva-Miranda, Patricia Arce-Paredes, Oscar Rojas-Espinosa   +2 more
doaj   +1 more source

Make It Simple: (SR-A1+TLR7) Macrophage Targeted NANOarchaeosomes

Frontiers in Bioengineering and Biotechnology, 2018
Hyperhalophilic archaebacteria exclusively produce sn2,3 diphytanylglycerol diether archaeolipids, unique structures absent in bacteria and eukaryotes. Nanovesicles made of archaeolipids known as nanoarchaeosomes (nanoARC), possess highly stable bilayers,
Federico Leonel Parra, Ayelen Tatiana Caimi, Maria Julia Altube, Diego Esteban Cargnelutti, Mónica Elba Vermeulen, Marcelo Alexandre de Farias, Rodrigo Villares Portugal, Maria Jose Morilla, Eder Lilia Romero   +8 more
doaj   +1 more source

Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice

JACC: Basic to Translational Science, 2019
Summary: Mitochondrial deoxyribonucleic acid, containing the unmethylated cytidine-phosphate-guanosine motif, stimulates Toll-like receptor 9 to induce inflammation and heart failure.
Hiromichi Ueda, MD, Osamu Yamaguchi, MD, PhD, Manabu Taneike, MD, PhD, Yasuhiro Akazawa, MD, Haruko Wada-Kobayashi, MD, Ryuta Sugihara, MD, Hiroki Yorifuji, MD, Hiroyuki Nakayama, MD, PhD, Shigemiki Omiya, MD, PhD, Tomokazu Murakawa, MD, PhD, Yasushi Sakata, MD, PhD, Kinya Otsu, MD, PhD   +11 more
doaj   +1 more source

Expression of high mobility group B1 and toll-like receptor-nuclear factor κB signaling pathway in chronic subdural hematomas.

PLoS ONE, 2020
Chronic subdural hematoma (CSDH) is an angiogenic and inflammatory disease. Toll-like receptors (TLRs) transduce intracellular signals, resulting in the activation of nuclear factor κB (NF-κB), which leads to the production of inflammatory cytokines ...
Koji Osuka, Yasuo Watanabe, Nobuteru Usuda, Kenichiro Iwami, Shigeru Miyachi, Masakazu Takayasu   +5 more
doaj   +1 more source