Results 11 to 20 of about 14,758,329 (299)

Sequence and Structural Characterization of Toll-Like Receptor 6 from Human and Related Species. [PDF]

Biomed Res Int, 2021
Toll‐like receptors (TLRs) play an important role in the innate immune response against various pathogens. They serve as expected targets of natural selection in those species which are adapted to habitats with contrasting pathogen burdens. Till date, sufficient literature about TLRs especially TLR6 is not available.
Mustafa G, Mahrosh HS, Arif R.
europepmc   +4 more sources

Polymorphisms within the Toll-Like Receptor (TLR)-2, -4, and -6 Genes in Cattle [PDF]

Diversity, 2009
In mammals, members of the TLR gene family play a primary role in the recognition of pathogen-associated molecular patterns from bacteria, viruses, protozoa and fungi.
Marco Mariotti, John L. Williams, Susana Dunner, Alessio Valentini, Lorraine Pariset   +4 more
doaj   +3 more sources

Toll-like receptor 6 expression, sequence variants, and their association with colorectal cancer risk. [PDF]

J Cancer, 2019
This is the first study to examine the potential correlation of the rs3796508 and rs5743810 SNPs of the TLR6 gene in patients with colorectal cancer (CRC) in a subset of the Saudi population. TLR6 gene expression was studied by real-time PCR assaysin 10 matching normal and cancer colon tissues.
Semlali A, Almutairi M, Pathan AAK, Azzi A, Parine NR, AlAmri A, Arafah M, Aljebreen AM, Alharbi O, Almadi MA, Azzam NA, Alanazi M, Rouabhia M.   +12 more
europepmc   +4 more sources

A study of the modulation of Toll-like receptor signalling in macrophages by Annexin-1 [PDF]

, 2011
PhDAnnexin-A1 (AnxA1) is an endogenous anti-inflammatory protein that has been shown to exert a protective role against the lethal effects induced by the Toll-like receptor (TLR) 4 agonist lipopolysaccharide (LPS).
Polycarpou, Anastasia
core   +4 more sources

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer [PDF]

Immunity, 2009
Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA complexes.
Kang, JY Kang, Jin Young, Nan, X Nan, Xuehua, Jin, MS Jin, Mi Sun, Youn, SJ Youn, Suk-Jun, Ryu, YH Ryu, Young Hee, Mah, S Mah, Shinjee, Han, SH Han, Seung Hyun, Lee, H Lee, Hayyoung, Paik, SG Paik, Sang-Gi, Lee, JO Lee, Jie-Oh   +9 more
openaire   +3 more sources

Species-Specific Recognition of Aspergillus fumigatus by Toll-like Receptor 1 and Toll-like Receptor 6 [PDF]

The Journal of Infectious Diseases, 2012
Aspergillus fumigatus causes invasive aspergillosis, a potentially fatal infection in oncohematological patients. Innate immune detection of A. fumigatus involves Toll-like receptor (TLR) 4 and TLR2, which forms a heterodimer with either TLR1 or TLR6.
Rubino I., Coste A., Le Roy D., Roger T., Jaton K., Boeckh M., Monod M., Latgé J.-P., Calandra T., Bochud P.-Y.   +9 more
openaire   +4 more sources

Discrimination of bacterial lipoproteins by Toll-like receptor 6 [PDF]

International Immunology, 2001
Bacterial lipoproteins (BLP) trigger immune responses via Toll-like receptor 2 (TLR2) and their immunostimulatory properties are attributed to the presence of a lipoylated N-terminus. Most BLP are triacylated at the N-terminus cysteine residue, but mycoplasmal macrophage-activating lipopeptide-2 kD (MALP-2) is only diacylated.
O, Takeuchi, T, Kawai, P F, Mühlradt, M, Morr, J D, Radolf, A, Zychlinsky, K, Takeda, S, Akira   +7 more
openaire   +2 more sources

Structural characterisation of Toll-like receptor 1 (TLR1) and Toll-like receptor 6 (TLR6) in elephant and harbor seals [PDF]

Veterinary Immunology and Immunopathology, 2016
Pinnipeds are a diverse clade of semi-aquatic mammals, which act as key indicators of ecosystem health. Their transition from land to marine environments provides a complex microbial milieu, making them vulnerable to both aquatic and terrestrial pathogens, thereby contributing to pinniped population decline.
Woodman, Sally, Gibson, Amanda J., Garcia, Ana Rubio, Contreras, Guillermo Sanchez, Rossen, John W., Werling, Dirk, Offord, Victoria   +6 more
openaire   +2 more sources

Polymorphisms within the Toll-like receptor (TLR)-2, -4, and -6 genes in cattle

Italian Journal of Animal Science, 2010
In mammals, members of the TLR gene family play a primary role in the recognition of pathogen-associated molecular patterns from bacteria, viruses, protozoa and fungi. Recently, cattle TLR genes have been mapped to chromosomes using a radiation hybrid panel.
A. Valentini, G. De Matteis, S. Failla, C. Marchitelli, F. Napolitano, A. Crisà, M. Mariotti, L. Pariset   +7 more
doaj   +2 more sources

Preliminary X-ray crystallographic studies of the TIR domain of human Toll-like receptor 6. [PDF]

Acta Crystallogr F Struct Biol Commun, 2014
Toll-like receptor (TLR) proteins have been identified and shown to play a role in the innate immune response. TLR6 associated with TLR2 can recognize diacylated lipoprotein. In this study, the human TLR6 TIR domain corresponding to amino acids 640–796 was overexpressed inEscherichia coliusing engineered C-terminal His tags.
Jang TH, Park HH.
europepmc   +4 more sources