Results 31 to 40 of about 14,758,329 (299)
Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes [PDF]
Rheumatology, 2010 To determine whether vitamin D(3) modulates monocytic expression of intracellular Toll-like receptors (TLRs) 3, 7 and 9.Human monocytes were isolated from peripheral blood and cultured with 100 nM vitamin D(3) for 24, 48 and 72 h. Expression of CD14 and TLR2, TLR3, TLR4, TLR7 and TLR9 were examined by flow cytometry.
Laura J, Dickie +5 more
openaire +2 more sources
Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling [PDF]
Scientific Reports, 2019 AbstractSignaling of the pleiotropic cytokine Interleukin-6 (IL-6) via its soluble IL-6R (sIL-6R) has been termed trans-signaling and is thought to be responsible for the pro-inflammatory properties of IL-6. The sIL-6R can be generated by alternative mRNA splicing or proteolytic cleavage of the membrane-bound IL-6R. However, which stimuli induce sIL-6R
Charlotte M. Flynn +8 more
openaire +2 more sources
FEBS Open Bio, 2023 Obstructive sleep apnea (OSA) is characterized by the collapse of the soft palate in the upper airway, resulting in chronic intermittent hypoxia during sleep.
Tiantian Su +6 more
doaj +1 more source
, 2005 Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
Anders, Hans-Joachim, H-J Anders
core +1 more source
Toll-like receptors 2 and 6 mediate apoptosis and inflammation in ischemic skeletal myotubes [PDF]
Vascular Medicine, 2019 Critical limb ischemia (CLI) is associated with skeletal muscle damage. However, the pathophysiology of the muscle damage is poorly understood. Toll-like receptors (TLR) have been attributed to play a role in ischemia-induced tissue damage but their role in skeletal muscle damage in CLI is unknown.
Hemanshu Patel +7 more
openaire +5 more sources
Rice sprouts exert immunostimulatory activity in mouse macrophages, RAW264.7 cells
Food and Agricultural Immunology, 2021 Rice sprouts are reported to have potential as a functional food agent for health promotion, but studies on the biological activity of rice sprouts are insufficient. Thus, in this study, we investigated whether WERS exhibits immunostimulatory activity in
Na Gyeong Geum +6 more
doaj +1 more source
Frontiers in Immunology, 2018 Systemic sclerosis (SSc) is a poorly understood heterogeneous condition with progressive multi-organ fibrosis. Recent genetic and genomic evidence suggest a pathogenic role for dysregulated innate immunity and toll-like receptor (TLR) activity in SSc ...
Swati Bhattacharyya +7 more
doaj +1 more source
Journal of Neuroinflammation, 2023 Background Mounting evidence suggests that the immune system plays detrimental or protective roles in nerve injury and repair. Main body Herein we report that both CD11bhiLy6Ghi and CD11bhiLy6ChiLy6Glo myeloid cells are required to protect corneal nerves
Hyun Ju Lee +3 more
doaj +1 more source
Effect of smoking on the genetic makeup of toll-like receptors 2 and 6
OncoTargets and Therapy, 2016 Cigarette smoking is a major risk factor for lung cancer, asthma, and oral cancer, and is central to the altered innate immune responsiveness to infection. Many hypotheses have provided evidence that cigarette smoking induces more genetic changes in genes involved in the development of many cigarette-related diseases. This alteration may be from single-
Kohailan,Muhammad +8 more
openaire +4 more sources
Chicken Toll-like Receptor 3 Recognizes Its Cognate Ligand When Ectopically Expressed in Human Cells [PDF]
, 2007 Recognition of pathogens by toll-like receptors (TLRs) causes activation of signaling cascades that trigger cytokine secretion and, ultimately, innate immunity.
Kothlow, Sonja +8 more
core +1 more source