Results 31 to 40 of about 9,070 (169)

Contribution of toll-like receptor 2 and nicotinamide adenine dinucleotide phosphate oxidase to the trimethylamine N-oxide-induced inflammatory reactions in U937-derived macrophages [PDF]

ARYA Atherosclerosis, 2021
BACKGROUND: Trimethylamine N-oxide (TMAO) is emerging as a new generation of metabolites related to the activation of inflammatory reactions in the macrophages during atherosclerosis.
Abbas Ahmadi, Zakaria Vahabzadeh, Mohammadraman Moloudi, Leila Farhadi, Sara Shirahmadi   +4 more
doaj   +1 more source

Toll-like receptor 6 inhibits colorectal cancer progression by suppressing NF-κB signaling

Heliyon
Background: Toll-like receptors (TLRs) are implicated in the pathogenesis and progression of inflammation-associated cancers, except their role in regulating innate immunity.
Lina Ma, Yancun Yin, Zhenhai Yu, Ning Xu, Lianhuan Ma, Weiwei Qiao, Xiaowen Zhen, Fan Yang, Naili Zhang, Yue Yu   +9 more
doaj   +1 more source

Polymorphism of genes of Toll-like receptors as a potential factor of predisposition to tuberculosis

Туберкулез и болезни лёгких, 2018
The objective of the study: to detect genotypes and frequency of gene alleles of Toll-receptors (Arg753Gln – for TLR2; Phe412Leu – for TLR3; Asp299Gly – for TLR4; Ser249Pro – for TLR6) among respiratory tuberculosis patients in Zabaykalsky Kray.Subjects ...
E. S. Bogodukhovа, E. E. Bаyke
doaj   +1 more source

Identification of TLR2/TLR6 signalling lactic acid bacteria for supporting immune regulation [PDF]

Scientific Reports, 2016
AbstractAlthough many lactic acid bacteria (LAB) influence the consumer’s immune status it is not completely understood how this is established. Bacteria-host interactions between bacterial cell-wall components and toll-like receptors (TLRs) have been suggested to play an essential role.
Chengcheng Ren, Qiuxiang Zhang, Bart J. de Haan, Hao Zhang, Marijke M. Faas, Paul de Vos   +5 more
openaire   +3 more sources

Development of N-Acetylated Dipalmitoyl-S-Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists

Molecules, 2019
Cancer vaccine is a promising immunotherapeutic approach to train the immune system with vaccines to recognize and eliminate tumors. Adjuvants are compounds that are necessary in cancer vaccines to mimic an infection process and amplify immune responses.
Yang Zhou, Abid H. Banday, Victor J. Hruby, Minying Cai   +3 more
doaj   +1 more source

Surface-Expressed TLR6 Participates in the Recognition of Diacylated Lipopeptide and Peptidoglycan in Human Cells [PDF]

The Journal of Immunology, 2005
Abstract Recognition of microbial components by TLR2 requires cooperation with other TLRs. TLR6 has been shown to be required for the recognition of diacylated lipoproteins and lipopeptides derived from mycoplasma and to activate the NF-κB signaling cascade in conjunction with TLR2.
Yoshiya, Nakao, Kenji, Funami, Satomi, Kikkawa, Mitsue, Taniguchi, Miyuki, Nishiguchi, Yasuhiro, Fukumori, Tsukasa, Seya, Misako, Matsumoto   +7 more
openaire   +2 more sources

MicroRNA-494-3p alleviates inflammatory response in sepsis by targeting TLR6.

European review for medical and pharmacological sciences, 2019
To clarify whether microRNA-494-3p could exert an anti-inflammation effect by suppressing the expression of toll-like receptor 6 (TLR6), thus inhibiting the development of sepsis.Plasma levels of microRNA-494-3p and TLR6 in sepsis patients and healthy controls were determined by quantitative real-time polymerase chain reaction (qRT-PCR).
Wang, H.-F., Li, Y., Wang, Y.-Q., Li, H.-J., Dou, L.   +4 more
openaire   +2 more sources

Association of TLR2 and TLR6 gene polymorphism with Trichomoniasis vaginalis Infection

Advancements in Life Sciences, 2023
Background: Toll-like receptors (TLR2 and TLR6) are a group of receptors that play a crucial role in the innate immune response and recognition of T. vaginalis. Single nucleotide polymorphisms (SNPs) in TLRs were manifested as important determinant affecting the susceptibility to trichomoniasis. This study aims to examine the impact of rs5743708 SNP in
Zainab Waddah Kermasha, Hayam Khalis Al-Masoudi, Suhaila Fadhil Al-Shaikh   +2 more
openaire   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

АССОЦИАЦИЯ ПОЛИМОРФИЗМОВ ГЕНОВ TLR2, TLR4 И TLR6 С КОЛОНИЗАЦИЕЙ STREPTOCOCCUS PNEUMONIAE У РАБОТНИКОВ МЕТАЛЛУРГИЧЕСКОГО ПРОИЗВОДСТВА

Медицина в Кузбассе
Работники предприятий черной металлургии подвергаются воздействию промышленных аэрозолей органической и неорганической природы, что может приводить к нарушению механизмов врожденного иммунитета и увеличению частоты респираторных инфекций.
Татьяна Викторовна Бушуева, Елизавета Павловна Артёменко, Наталья Алексеевна Рослая, Юлия Витальевна Грибова, Алла Константиновна Лабзова, Владимир Борисович Гурвич   +5 more
doaj   +1 more source