Results 31 to 40 of about 18,028 (232)

The TLR2/TLR6 ligand FSL-1 mitigates radiation-induced hematopoietic injury in mice and nonhuman primates

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Therapies are needed to address worldwide concerns of nuclear terrorism, accidents, and injuries caused by radiation. We demonstrate that life-threatening hematopoietic injuries in mice and nonhuman primates due to radiation are mitigated ...
BridgeBio Gene Therapy, W. Brickey, David L. Caudell, Andrew N. Macintyre, John D. Olson, Yanwan Dai, Sirui Li, Gregory O. Dugan, J. D. Bourland, Lisa M O'Donnell, J. A. Tooze, Guannan Huang, Shuangshuang Yang, Hao Guo, Matthew French, Allison N. Schorzman, William C Zamboni, Gregory D. Sempowski, Zhiguo Li, K. Owzar, Nelson J. Chao, J. M. Cline, Jenny P. Y. Ting   +22 more
semanticscholar   +1 more source

An 192 bp ERV Insertion in the First Intron of TLR6 Acts as an Enhancer to Increase TLR6 and TLR1 Expression [PDF]

, 2020
Abstract BackgroundToll-like receptors (TLRs) play important roles in building innate immune and inducing adaptive immune responses. Associations of the TLR gene polymorphisms with diseases susceptibility, which are the basis of molecular breeding for disease resistant animals, have been reported extensively.
xiaoyan wang, Zixuan Chen, Eduard Murani, Enrico D'alessandro, Yalong An, Cai Chen, Kui Li, Grazia Galeano, Klaus Wimmers, Chengyi Song   +9 more
openaire   +4 more sources

TLR6 Modulates First Trimester Trophoblast Responses to Peptidoglycan [PDF]

The Journal of Immunology, 2008
Abstract Intrauterine bacterial infections are a well-established cause of pregnancy complications. One key observation in a number of abnormal pregnancies is that placental apoptosis is significantly elevated. First trimester trophoblast cells are known to express TLR1 and TLR2 and to undergo apoptosis following exposure to Gram ...
Vikki M, Abrahams, Paulomi B, Aldo, Shaun P, Murphy, Irene, Visintin, Kaori, Koga, Gabriella, Wilson, Roberto, Romero, Surendra, Sharma, Gil, Mor   +8 more
openaire   +2 more sources

Single Nucleotide Variants in the TLR1, TLR2 and TLR6 Genes: A Case–Control Study in a Colombian Population

Tropical Medicine and Infectious Disease, 2023
Background: Single nucleotide variants in toll-like receptor genes play a crucial role in leprosy susceptibility or resistance. Methods: With an epidemiology case–control study, associations between SNVs rs5743618 in TLR1, rs5743708 in TLR2, and ...
L. Gutiérrez-Castañeda, C. R. Acosta, M. A. Bustos, Diana García, Diana P. Bohada, Raúl Rodríguez, M. Guerrero   +6 more
semanticscholar   +1 more source

TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes. [PDF]

PLoS ONE, 2011
After infection with Borrelia species, the risk for developing Lyme disease varies significantly between individuals. Recognition of Borrelia by the immune system is mediated by pattern recognition receptors (PRRs), such as TLRs.
Marije Oosting, Hadewych Ter Hofstede, Patrick Sturm, Gosse J Adema, Bart-Jan Kullberg, Jos W M van der Meer, Mihai G Netea, Leo A B Joosten   +7 more
doaj   +1 more source

Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6 [PDF]

Immunology & Cell Biology, 2017
The secreted hexameric form of the dengue virus (DENV) non‐structural protein 1 (NS1) has recently been shown to elicit inflammatory cytokine release and disrupt endothelial cell monolayer integrity. This suggests that circulating NS1 contributes to the vascular leak that plays a major role in the pathology of dengue haemorrhagic fever and shock ...
Naphak Modhiran, D. Watterson, A. Blumenthal, A. Baxter, P. Young, K. Stacey   +5 more
semanticscholar   +4 more sources

Aberrant DNA methylation of the toll-like receptors 2 and 6 genes in patients with obstructive sleep apnea.

PLoS ONE, 2020
Obstructive sleep apnea (OSA) is a syndrome leading to chronic intermittent hypoxia, and the up-regulation of toll-like receptors (TLR) 2 and 6 on peripheral blood cells has been reported.
Kuo-Tung Huang, Yung-Che Chen, Chia-Cheng Tseng, Huang-Chih Chang, Mao-Chang Su, Ting-Ya Wang, Yong-Yong Lin, Yi-Xin Zheng, Jen-Chieh Chang, Chien-Hung Chin, Chang-Chun Hsiao, Meng-Chih Lin   +11 more
doaj   +1 more source

Association of Haematological Parameters With TLR Genes in Healthy and Distemper‐Infected Dogs Haematology and TLRs in Distemper [PDF]

Vet Med Sci
The distemper‐infected dogs presented with an upregulated expression of the immune recognition receptors TLR3, TLR4 and TLR9. In the distemper‐infected dogs, there was a positive correlation between the TLR1 and PWD, TLR4 and WBC, Gran and Gran%, TLR5 and HCT, TLR6 and Gran%, TLR7 and MCV and TLR7 and PDW, as well as a negative correlation between the ...
Karaca Bekdik İ, Daldaban F, Arslan K, Akyüz B, Aslan Ö.   +4 more
europepmc   +2 more sources

Role of TLR1 and TLR6 in the host defense against disseminated candidiasis [PDF]

FEMS Immunology & Medical Microbiology, 2008
Toll-like receptor-1 (TLR1) and TLR6 are receptors of the TLR family that form heterodimers with TLR2. The role of TLR1 and TLR6 for the recognition of the fungal pathogen Candida albicans was investigated. TLR1 is not involved in the recognition of C.
Netea, M.G., Veerdonk, F.L. van de, Verschueren, I., Meer, J.W.M. van der, Kullberg, B.J.   +4 more
openaire   +3 more sources

Role of cytokine and Toll-like receptor genes in pathogenesis of inborn heart disease

Медицинская иммунология, 2022
Sporadic congenital heart disease (CHD) may result from immune disorders in the mother – embryo system and/or constitutional disorders in regulatory systems, including those associated with TLR receptors, cytokines and their receptors.
A. V. Shabaldin, A. V. Sinitskaya, S. A. Shmulevich   +2 more
doaj   +1 more source