Toll-like receptor 1 predicts favorable prognosis in pancreatic cancer. [PDF]
PLoS ONE, 2019 BackgroundThe link between inflammation and carcinogenesis is indisputable. In trying to understand key factors at play, cancer research has developed an interest in the toll-like receptors (TLRs), which have shown signs of having prognostic value in ...
Mira Lanki +4 more
doaj +6 more sources
Synergistic Effects of Toll-Like Receptor 1/2 and Toll-Like Receptor 3 Signaling Triggering Interleukin 27 Gene Expression in Chikungunya Virus-Infected Macrophages [PDF]
Frontiers in Cell and Developmental Biology, 2022 Chikungunya virus (CHIKV) is the etiological agent of chikungunya fever (CHIKF), a self-limiting disease characterized by myalgia and severe acute or chronic arthralgia. CHIKF is associated with immunopathology and high levels of pro-inflammatory factors.
Juan Felipe Valdés-López +2 more
doaj +2 more sources
Toll-like receptor 1 as a possible target in non-alcoholic fatty liver disease [PDF]
Scientific Reports, 2021 Toll-like receptors (TLRs) in the liver compartment have repeatedly been attributed to the development of non-alcoholic fatty liver disease (NAFLD).
Anja Baumann +9 more
doaj +2 more sources
Modulation of Toll-like receptor 1 intracellular domain structure and activity by Zn2+ ions [PDF]
Communications Biology, 2021 Lushpa et al report the structure and dynamics of the TLR1 toll-interleukin like (TIR) cytoplasmic domain in both crystal and solution. They demonstrate that the TLR1 TIR domain is capable of specific binding of Zn with nanomolar affinity, which appears ...
Vladislav A. Lushpa +12 more
doaj +2 more sources
Toll-Like Receptor-1 and Receptor-2 and Beta-Defensin in Postcholecystectomy Bile Duct Injury [PDF]
Gastroenterology Research and Practice, 2015 Postcholecystectomy bile duct injuries (BDI) produce hepatic cholestasis and cause infection of the biliary tract. The biliary cells participate in secreting cytokines and in expression of immune response receptors.
Alejandra Guillermina Miranda-Díaz +6 more
doaj +2 more sources
Synthetic Toll-Like Receptors for Control of Innate Immunity With Far-Red Light. [PDF]
Adv Sci (Weinh)Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Leopold AV, Verkhusha VV.
europepmc +2 more sources
Critical Care Explorations, 2021 OBJECTIVES:. Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock ...
Rafi Mazor, PhD +5 more
doaj +1 more source
Einstein (São Paulo), 2020 Objective To analyze and compare the expression of Toll-like receptors by regulatory T cells present in the peritoneal fluid of patients with and without endometriosis.
Camila Hernandes +5 more
doaj +2 more sources
Hyperreactivity of Blood Leukocytes in Patients with NAFLD to Ex Vivo Lipopolysaccharide Treatment Is Modulated by Metformin and Phosphatidylcholine but Not by Alpha Ketoglutarate. [PDF]
PLoS ONE, 2015 Toll-like receptor 4 and proinflammatory cytokines play a central role in the progression of nonalcoholic fatty liver disease. We investigated IL-1, IL-6 and TNFα production and toll-like receptor 4 in both--obese and lean patients with non-alcoholic ...
Agnieszka Zwolak +4 more
doaj +1 more source
Lack of an antibacterial response defect in Drosophila Toll-9 mutant. [PDF]
PLoS ONE, 2011 Toll and Toll-like receptors represent families of receptors involved in mediating innate immunity response in insects and mammals. Although Drosophila proteome contains multiple Toll paralogs, Toll-1 is, so far, the only receptor to which an immune role
Karine Narbonne-Reveau +2 more
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