Results 11 to 20 of about 34,084,722 (297)

MicroRNAs and Toll-like Receptor/Interleukin-1 Receptor Signaling [PDF]

Journal of Hematology & Oncology, 2012
The discovery of miRNAs has revolutionized the way we examine the genome, RNA products, and the regulation of transcription and translation. Their ability to modulate protein expression through mRNA degradation and translation repression resulted in avid
Virtue Anthony, Wang Hong, Yang Xiao-feng   +2 more
doaj   +3 more sources

Leprosy and the adaptation of human toll-like receptor 1.

PLoS Pathogens, 2010
Leprosy is an infectious disease caused by the obligate intracellular pathogen Mycobacterium leprae and remains endemic in many parts of the world.
Sunny H Wong, Sailesh Gochhait, Dheeraj Malhotra, Fredrik H Pettersson, Yik Y Teo, Chiea C Khor, Anna Rautanen, Stephen J Chapman, Tara C Mills, Amit Srivastava, Amit Srivastava, Aleksey Rudko, Maxim B Freidin, Valery P Puzyrev, Shafat Ali, Shweta Aggarwal, Rupali Chopra, Belum S N Reddy, Vijay K Garg, Suchismita Roy, Sarah Meisner, Sunil K Hazra, Bibhuti Saha, Sian Floyd, Brendan J Keating, Cecilia Kim, Benjamin P Fairfax, Julian C Knight, Philip C Hill, Richard A Adegbola, Hakon Hakonarson, Paul E M Fine, Ramasamy M Pitchappan, Rameshwar N K Bamezai, Adrian V S Hill, Fredrik O Vannberg   +35 more
doaj   +5 more sources

Effects of human Toll-like receptor 1 polymorphisms on ageing [PDF]

Immunity & Ageing, 2013
Background Advanced age results in crucial alterations of the innate and adaptive immune system leading to functional defects resulting in infection and chronic diseases.
Uciechowski Peter, Oellig Eva Maria, Mariani Erminia, Malavolta Marco, Mocchegiani Eugenio, Rink Lothar   +5 more
doaj   +5 more sources

The Use of Toll-Like Receptor Agonists in HIV-1 Cure Strategies [PDF]

Frontiers in Immunology, 2020
Toll-like receptors (TLRs) are a family of pattern recognition receptors and part of the first line of defense against invading microbes. In humans, we know of 10 different TLRs, which are expressed to varying degrees in immune cell subsets.
Janne Tegder Martinsen, Jesper Damsgaard Gunst, Jesper Falkesgaard Højen, Martin Tolstrup, Ole Schmeltz Søgaard   +4 more
doaj   +3 more sources

A study of the modulation of Toll-like receptor signalling in macrophages by Annexin-1 [PDF]

, 2011
PhDAnnexin-A1 (AnxA1) is an endogenous anti-inflammatory protein that has been shown to exert a protective role against the lethal effects induced by the Toll-like receptor (TLR) 4 agonist lipopolysaccharide (LPS).
Polycarpou, Anastasia
core   +4 more sources

Distribution of Toll‐like receptor 1 and Toll‐like receptor 2 in human lymphoid tissue [PDF]

Immunology, 2003
SummaryTo determine how distinct receptors of the immune system can contribute to innate immunity, we investigated the pattern of Toll‐like receptor 1 (TLR1) and TLR2 expression in human lymphoid tissue. We found that TLR1 and TLR2 were co‐expressed on cells of the innate immune system, including macrophages and dendritic cells.
Maria-Teresa, Ochoa, Annaliza J, Legaspi, Zena, Hatziris, Paul J, Godowski, Robert L, Modlin, Peter A, Sieling   +5 more
openaire   +2 more sources

Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells [PDF]

European Journal of Immunology, 2002
Toll-like receptor 4 (TLR4) is the signal-transducing component of the LPS recognition complex and is essential for LPS-induced septic shock. Here we demonstrate that TLR1 has the capacity to abrogate TLR4 signaling. Human microvascular endothelial cells express TLR4 but not TLR1 and respond to LPS through TLR4. The ability of these cells to respond to
Jessica H, Spitzer, Alberto, Visintin, Alessandra, Mazzoni, Margaret N, Kennedy, David M, Segal   +4 more
openaire   +2 more sources

Species-Specific Recognition of Aspergillus fumigatus by Toll-like Receptor 1 and Toll-like Receptor 6 [PDF]

The Journal of Infectious Diseases, 2012
Aspergillus fumigatus causes invasive aspergillosis, a potentially fatal infection in oncohematological patients. Innate immune detection of A. fumigatus involves Toll-like receptor (TLR) 4 and TLR2, which forms a heterodimer with either TLR1 or TLR6.
Rubino I., Coste A., Le Roy D., Roger T., Jaton K., Boeckh M., Monod M., Latgé J.-P., Calandra T., Bochud P.-Y.   +9 more
openaire   +4 more sources

Decoys and Regulatory “Receptors” of the IL-1/Toll-Like Receptor Superfamily [PDF]

Frontiers in Immunology, 2013
Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL-18BP) and "receptors" with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR ...
Cecilia eGarlanda, Federica eRiva, Eduardo eBonavita, Stefania eGentile, Alberto eMantovani, Alberto eMantovani   +5 more
openaire   +4 more sources

Toll-like receptor 1 polymorphisms increase susceptibility to candidemia. [PDF]

J Infect Dis, 2012
Candidemia is a severe invasive fungal infection with high mortality. Recognition of Candida species is mediated through pattern recognition receptors such as Toll-like receptors (TLRs). This study assessed whether genetic variation in TLR signaling influences susceptibility to candidemia.Thirteen mostly nonsynonymous single nucleotide polymorphisms ...
Plantinga TS, Johnson MD, Scott WK, van de Vosse E, Velez Edwards DR, Smith PB, Alexander BD, Yang JC, Kremer D, Laird GM, Oosting M, Joosten LA, van der Meer JW, van Dissel JT, Walsh TJ, Perfect JR, Kullberg BJ, Netea MG.   +17 more
europepmc   +7 more sources