Results 21 to 30 of about 34,084,722 (297)

Structural characterisation of Toll-like receptor 1 (TLR1) and Toll-like receptor 6 (TLR6) in elephant and harbor seals [PDF]

Veterinary Immunology and Immunopathology, 2016
Pinnipeds are a diverse clade of semi-aquatic mammals, which act as key indicators of ecosystem health. Their transition from land to marine environments provides a complex microbial milieu, making them vulnerable to both aquatic and terrestrial pathogens, thereby contributing to pinniped population decline.
Woodman, Sally, Gibson, Amanda J., Garcia, Ana Rubio, Contreras, Guillermo Sanchez, Rossen, John W., Werling, Dirk, Offord, Victoria   +6 more
openaire   +2 more sources

Alternate transcription of the Toll-like receptor signaling cascade [PDF]

, 2006
Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr) cascade has been shown to dramatically alter the signaling capacity of inflammatory cells, but it is not known how common this mechanism is. We provide transcriptional evidence
Kai, Chikatoshi, Forrest, A, Schroder, K, Forrest, Alistair, Kawai, J, Kawaji, H, Wells, Christine A, Faulkner, G, Carninci, P, Hume, DA, Carninci, Piero, Grimmond, SM, Himes, SR, Lo, Sandra, Hume, David, Schroder, Kate, Taylor, D, Grimmond, Sean M, Faulkner, Geoffrey, Chalk, Alistair, Kasukawa, T, Himes, S Roy, Grimmond, Sean, Kawai, Jun, Waddell, Nic, Lo, Yu-Lan Sandra, Hayashizaki, Yoshihide, Kasukawa, Takeya, Wells, Christine, Katayama, S, Hayashizaki, Y, Chalk, Alistair M, Katayama, Shintaro, Hume, David A, Chalk, AM, Taylor, Darrin, Kawaji, Hideya, Wells, CA, Waddell, N, Lo, S, Kai, C   +40 more
core   +1 more source

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett, Geoffrey L. Smith, Haga, Ismar R, Geraldine Maloney, Bowie, Andrew G., Bartlett, Nathan W., Martina Schröder, Ismar R. Haga, Haga, Ismar R., Patrick C. Reading, Andrew G. Bowie, Fitzgerald, Katherine A, Smith, Geoffrey L, Schroeder, Martina, Reading, Patrick C, Smith, Geoffrey L., Katherine A. Fitzgerald, Bartlett, Nathan W, Julianne Stack, Maloney, Geraldine, Bowie, Andrew G, Schröder, Martina, Reading, Patrick C., Stack, Julianne, Fitzgerald, Katherine A.   +24 more
core   +1 more source

Role of macrophage-mediated Toll-like receptor 4–interleukin-1R signaling in ectopic tongue pain associated with tooth pulp inflammation

Journal of Neuroinflammation, 2020
Background The existence of referred pain and ectopic paresthesia caused by tooth pulp inflammation may make definitive diagnosis difficult and cause misdiagnosis or mistreatment; thus, elucidation of that molecular mechanism is urgent.
Kohei Kanno, Kohei Shimizu, Masamichi Shinoda, Makoto Hayashi, Osamu Takeichi, Koichi Iwata   +5 more
doaj   +1 more source

Association analysis between the TLR9 gene polymorphism rs352140 and type 1 diabetes

Frontiers in Endocrinology, 2023
BackgroundTo a great extent, genetic factors contribute to the susceptibility to type 1 diabetes (T1D) development, and by triggering immune imbalance, Toll-like receptor (TLR) 9 is involved in the development of T1D. However, there is a lack of evidence
Yimeng Wang, Ying Xia, Yan Chen, Linling Xu, Xiaoxiao Sun, Jiaqi Li, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou   +9 more
doaj   +1 more source

Impaired clearance of apoptotic cells leads to HMGB1 release in the bone marrow of patients with myelodysplastic syndromes and induces TLR4-mediated cytokine production

Haematologica, 2013
Excessive pro-inflammatory cytokine production in the bone marrow has been associated with the pathogenesis of myelodysplastic syndromes. We herein investigated the involvement of toll-like receptors and their endogenous ligands in the induction ...
Maria Velegraki, Evaggelia Papakonstanti, Irene Mavroudi, Maria Psyllaki, Christos Tsatsanis, Anastasis Oulas, Ioannis Iliopoulos, Pavlos Katonis, Helen A. Papadaki   +8 more
doaj   +1 more source

CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo [PDF]

, 2007
Background Bacterial DNA containing motifs of unmethylated CpG dinucleotides (CpG-ODN) initiate an innate immune response mediated by the pattern recognition receptor Toll-like receptor 9 (TLR9).
Schwederski Markus, Koch, Alexander, Schwederski, Markus, Ehrentraut Heidi, Baumgarten, Georg, Ehrentraut, Heidi, Hoeft, Andreas, Velten, Markus, Knüfermann, Pascal, Zacharowski Kai, Hoeft Andreas, Mersmann Jan, Knuefermann Pascal, Meyer Rainer, Grohé Christian, Baumgarten Georg, Zacharowski, Kai, Koch Alexander, Meyer, Rainer, Grohé, Christian, Velten Markus, Mersmann, Jan   +21 more
core   +1 more source

Characterization of toll-like receptors 1–10 in spotted hyenas [PDF]

Veterinary Research Communications, 2014
Previous research has shown that spotted hyenas (Crocuta crocuta) regularly survive exposure to deadly pathogens such as rabies, canine distemper virus, and anthrax, suggesting that they have robust immune defenses. Toll-like receptors (TLRs) recognize conserved molecular patterns and initiate a wide range of innate and adaptive immune responses.
Andrew S, Flies, Matthew T, Maksimoski, Linda S, Mansfield, Mary L, Weldele, Kay E, Holekamp   +4 more
openaire   +2 more sources

Molecular alterations of the TLR4-signaling cascade in canine epilepsy

BMC Veterinary Research, 2020
Background Cumulating evidence from rodent models points to a pathophysiological role of inflammatory signaling in the epileptic brain with Toll-like receptor-4 signaling acting as one key factor.
Eva-Lotta von Rüden, Fabio Gualtieri, Katharina Schönhoff, Maria Reiber, Fabio Wolf, Wolfgang Baumgärtner, Florian Hansmann, Andrea Tipold, Heidrun Potschka   +8 more
doaj   +1 more source

Mannan-binding lectin inhibits Candida albicans-induced cellular responses in PMA-activated THP-1 cells through Toll-like receptor 2 and Toll-like receptor 4. [PDF]

PLoS ONE, 2013
BACKGROUND:Candida albicans (C. albicans), the most common human fungal pathogen, can cause fatal systemic infections under certain circumstances. Mannan-binding lectin (MBL),a member of the collectin family in the C-type lectin superfamily, is an ...
Mingyong Wang, Fanping Wang, Jianbin Yang, Dongfang Zhao, Hongpo Wang, Feng Shao, Wenjun Wang, Ruili Sun, Mingzhi Ling, Jingjing Zhai, Shijun Song   +10 more
doaj   +1 more source