Results 51 to 60 of about 10,412 (198)

АССОЦИАЦИЯ ПОЛИМОРФИЗМОВ ГЕНОВ TLR2, TLR4 И TLR6 С КОЛОНИЗАЦИЕЙ STREPTOCOCCUS PNEUMONIAE У РАБОТНИКОВ МЕТАЛЛУРГИЧЕСКОГО ПРОИЗВОДСТВА

open access: yesМедицина в Кузбассе
Работники предприятий черной металлургии подвергаются воздействию промышленных аэрозолей органической и неорганической природы, что может приводить к нарушению механизмов врожденного иммунитета и увеличению частоты респираторных инфекций.
Татьяна Викторовна Бушуева   +5 more
doaj   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

open access: yesAdvanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang   +7 more
wiley   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

open access: yesAdvanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi   +6 more
wiley   +1 more source

DV NS1 protein activates TLR6 of mice.

open access: yes, 2015
ELISA was performed to quantify the amount of IL-6 (A) and TNF-α (B) secreted into the supernatant by His-tag (1 μg/ml), DV NS1 recombinant protein (1 μg/ml), MALP-2 (50 ng/ml), Ultrapure LPS (2.5 x 104 EU/ml), mock-infected or DV2-infected (M.O.I of 10)
Jincheng Chen (777546)   +2 more
core   +1 more source

Isolated Toll-like receptor transmembrane domains are capable of oligomerization. [PDF]

open access: yesPLoS ONE, 2012
Toll-like receptors (TLRs) act as the first line of defense against bacterial and viral pathogens by initiating critical defense signals upon dimer activation.
James I Godfroy   +4 more
doaj   +1 more source

Sperm activate TLR2/TLR1 heterodimerization to induce a weak proinflammatory response in the bovine uterus

open access: yesFrontiers in Immunology, 2023
Toll-like receptor 2 (TLR2) signaling pathway is involved in the sperm-triggered uterine inflammatory response at insemination, but its precise mechanism at molecular-level remains unknown.
Alireza Mansouri   +6 more
doaj   +1 more source

Vaginal host–microbe signatures linked to placental outcomes in mares

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule   +7 more
wiley   +1 more source

Polymorphisms of inflammation-related genes and susceptibility to childhood leukemia: evidence from a meta-analysis of 16 published studies

open access: yesHematology, 2023
Objective: This study was to comprehensively clarify the associations between single nucleotide polymorphisms (SNPs) in inflammatory genes and the susceptibility to childhood leukemia.Methods: Eligible articles were collected from the databases of PubMed,
Qiuping Zeng   +5 more
doaj   +1 more source

Adaptive Immunity in Marsupials

open access: yesJournal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol   +2 more
wiley   +1 more source

Expression of TLR2 and TLR6 of DV2-infected PBMC.

open access: yes, 2015
(A) Growth curve of DV2 in PBMC was determined using plaque assays (0 hr, 6 hrs, 1 to 5 days). Values plotted are mean ± SEM of three independent experiments performed in triplicates obtained using separate PBMC from three donors.
Jincheng Chen (777546)   +2 more
core   +1 more source

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