Toll-like receptor 6 inhibits colorectal cancer progression by suppressing NF-κB signaling
HeliyonBackground: Toll-like receptors (TLRs) are implicated in the pathogenesis and progression of inflammation-associated cancers, except their role in regulating innate immunity.
Lina Ma +9 more
doaj +1 more source
Polymorphism of genes of Toll-like receptors as a potential factor of predisposition to tuberculosis
Туберкулез и болезни лёгких, 2018 The objective of the study: to detect genotypes and frequency of gene alleles of Toll-receptors (Arg753Gln – for TLR2; Phe412Leu – for TLR3; Asp299Gly – for TLR4; Ser249Pro – for TLR6) among respiratory tuberculosis patients in Zabaykalsky Kray.Subjects ...
E. S. Bogodukhovа, E. E. Bаyke
doaj +1 more source
Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages [PDF]
, 2018 open11noSeveral studies suggest that curcumin and related compounds possess antioxidant and anti-inflammatory properties including modulation of lipopolysaccharide- (LPS-) mediated signalling in macrophage cell models. We here investigated the effects of
core +1 more source
Expression of Toll-like receptors in nasal epithelium in allergic rhinitis [PDF]
, 2015 Toll-like receptors (TLRs) are important in barrier homeostasis, but their role in airborne allergies is not fully understood. The aim was to evaluate baseline and allergen-induced expression of TLR proteins in nasal epithelium during allergic rhinitis ...
Haglund, Caj +8 more
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Isolation site influences virulence phenotype of serotype 14 Streptococcus pneumoniae strains belonging to multilocus sequence type 15 [PDF]
, 2015 Streptococcus pneumoniae is a diverse species causing invasive as well as localized infections that result in massive global morbidity and mortality. Strains vary markedly in pathogenic potential, but the molecular basis is obscured by the diversity and ...
Amin, Zarina +6 more
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Profile of toll-like receptor mRNA expression in the choroid plexus in adult ewes [PDF]
, 2014 The blood-cerebrospinal fluid barrier (BCSFB) located in the epithelial cells of the choroid plexus (CP) forms the interface between the cerebrospinal fluid (CSF) and pathogen components circulating in the blood.
Herman, Andrzej +4 more
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Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis [PDF]
, 2016 The endosymbiotic bacteria, Wolbachia, induce neutrophilic responses to the human helminth pathogen Onchocerca volvulus. The formation of Neutrophil Extracellular Traps (NETs), has been implicated in anti-microbial defence, but has not been identified in
Edwards, SW +7 more
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Keratinocytes from human skin respond as typical immune cells after the stimulation with _Trichophyton rubrum_ [PDF]
, 2007 _Trichophyton rubrum_ is the main agent causing dermatophytosis (1). Keratinocytes are considered to be the first physical barrier of defense against pathogens (2). But not only a physical barrier.
Alfonso E. Islas-Rodrí +1 more
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Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients [PDF]
, 2011 Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs)
Koch, Alexander +9 more
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The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Acute lung injury (ALI) is a severe complication of sepsis, yet the role of lncRNA NORAD in its pathogenesis remains unclear. Using LPS‐stimulated BEAS‐2B and HBEC3‐KT cells as well as cecal ligation and puncture (CLP)‐induced ALI models in C57BL/6 mice, we found that NORAD expression was markedly upregulated and promoted cell injury ...
Han Liu +4 more
wiley +1 more source