Results 61 to 70 of about 9,070 (169)

Hirudin Attenuates Uric Acid‐Induced Renal Tubular Injury via TNFRSF6B‐Mediated Suppression of NF‐κB Signaling

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Hyperuricemia, characterized by elevated serum uric acid (SUA) levels, is increasingly recognized as a pathological contributor to renal injury through oxidative stress, inflammation, and apoptosis. Hirudin, a thrombin inhibitor derived from leech saliva, has recently been noted for its anti‐inflammatory properties, yet its role in ...
Yingxue Zhao, Yongjie Qin, Lanzhi He, Haikun Luo, Ying Mo, Weihai Zhou, Huamei He, Ganping Zhou, Xihua Liu   +8 more
wiley   +1 more source

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source

Japanese Encephalitis Virus and Host Innate Immunity: Insights Into TLR Signaling, PRR Crosstalk, and Viral Immune Evasion

Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.
ABSTRACT Japanese encephalitis virus (JEV), a neurotropic flavivirus and a major cause of viral encephalitis, poses a significant global health threat due to its neuroinvasive potential. Host innate immune responses, particularly those mediated by pattern‐recognition receptors such as Toll‐like receptors (TLRs) and RIG‐I–like receptors, play critical ...
Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama‐Kohara   +2 more
wiley   +1 more source

Dietary Supplementation of Rumen‐Inert Fatty Acids and Rumen‐Protected Choline Modulates the Uterine Environment of Pregnant Beef Cows

Molecular Reproduction and Development, Volume 93, Issue 7, July 2026.
This graphical abstract summarizes that dietary supplementation of pregnant beef cows with unsaturated fatty acids and choline can increase (green) the concentration of metabolites in the uterine luminal fluid and alter the endometrial epithelial transcriptome during the peri‐elongation period (upregulation = green and downregulation = red).
Megan Bahr, Allyson McCarty, Zaeem Sarwar, Damon Smith, Matt Poore, Daniel Poole, Nadia Ashrafi, Romana Mimi, Stewart Graham, Ky Pohler, Jose Santos, Christian Maltecca, Felipe A. C. C. Silva   +12 more
wiley   +1 more source

Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap data.

PLoS ONE, 2012
Genetic epidemiological studies of complex diseases often rely on data from the International HapMap Consortium for identification of single nucleotide polymorphisms (SNPs), particularly those that tag haplotypes.
Allison R Baker, Feiyou Qiu, April Kaur Randhawa, David J Horne, Mark D Adams, Muki Shey, Jill Barnholtz-Sloan, Harriet Mayanja-Kizza, Gilla Kaplan, Willem A Hanekom, W Henry Boom, Thomas R Hawn, Catherine M Stein, Tuberculosis Research Unit and South African Tuberculosis Vaccine Initiative Team   +13 more
doaj   +1 more source

TLR-dependent control of Francisella tularensis infection and host inflammatory responses. [PDF]

PLoS ONE, 2009
BACKGROUND:Francisella tularensis is the causative agent of tularemia and is classified as a Category A select agent. Recent studies have implicated TLR2 as a critical element in the host protective response to F.
Allison L Abplanalp, Ian R Morris, Bijaya K Parida, Judy M Teale, Michael T Berton   +4 more
doaj   +1 more source

Hyaluronan (HA) Receptors: Discovery, Function & Pathology

Proteoglycan Research, Volume 4, Issue 3, July 2026.
ABSTRACT Hyaluronan (HA) is typically a long polymer of the repeating disaccharide, glucuronic acid‐β‐(1‐3)‐N‐acetylglucosamine polymerized by β(1‐4) bonds, with no obvious active site for biological activity. However, this dynamic polymer is vital for life in all metazoans and has a diverse array of functional characteristics due to the proteins that ...
Abby E. Bopp, Linda B. Pratt, Callan J. Schroder, Joseph D. Staab, Grant D. Hatcher, Joshua T. McWilliams, Michael C. Wilhelm, Ashley C. Texel, Edward N. Harris   +8 more
wiley   +1 more source

Beyond Hemostasis: Platelet Biomarkers and Vascular‐Immune Crosstalk in Dengue

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Several biomarkers are associated with platelet activation during dengue virus (DENV) infection. These include serum markers (AST, ALT, ferritin), platelet surface or secreted molecules (P‐selectin, PF4, RANTES, VEGF‐A, CD40L, TREM‐1, TLT‐1), immune and endothelial markers (TREM‐1, Ang‐1, Ang‐2), and viral components such as DENV EIII.
Amanda Beatriz Adriano da Silva‐Alencar, Amanda de Oliveira Matos, Daniel Francisco de Sousa, Jefferson do Carmo Dietz, Eugenio Damaceno Hottz, Marcelle Figueira Marques da Silva‐Sales, Helioswilton Sales‐Campos   +6 more
wiley   +1 more source

Protective Association of TLR6 rs5743810 with Pulmonary Tuberculosis in the Population of JAMMU Region

Indian Journal of Microbiology
Tuberculosis (TB) is an international public health problem that results in preventable deaths each year. About 10% of those infected develop tuberculosis, indicating that host defense factors play a significant role in the progression to active disease. Polymorphic variants in the genes determine genetic diversity among populations.
Sakshi Sharma, Indu priya, Isar Sharma, Suruchi Gupta, Rahul Gupta, Ritu Mahajan, Nisha Kapoor   +6 more
openaire   +2 more sources

Polymorphisms inTLR1, TLR6andTLR10genes and the risk of Graves’ disease

Autoimmunity, 2014
Graves' disease (GD) is postulated to be caused by the combined effects of susceptibility genes and environmental triggers. Toll-like receptors (TLRs) play a role in the activation of innate and adaptive immune responses in mammalians. The aim of this study was to evaluate the potential association of polymorphisms in TLR1, TLR6 and TLR10 genes with GD
WenJuan, Xiao, ZeLin, Liu, JiangHai, Lin, JingBo, Li, KeJing, Wu, Yun, Ma, YingXue, Gong, ZeHuan, Liu   +7 more
openaire   +2 more sources