Results 81 to 90 of about 10,412 (198)

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, Volume 293, Issue 18, Page 5558-5584, September 2026.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Single‐Cell Immune Profiling Suggests Non‐Classical Monocyte Is Associated Immunodepression in Tuberculosis Treatment Non‐Responders

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Sputum culture conversion (SCC) at 2 months is an early indicator of tuberculosis (TB) treatment response, yet the associated immune alterations remain incompletely defined. We performed single‐cell RNA sequencing on peripheral blood mononuclear cells from eight TB patients, stratified by 2‐month SCC status.
Yiqun Xiong, Yahong Qu, Ying Wang, Dongliang Zhang, Hao Shen, Weixin Wang, Junshun Gao, ZhenBo Wang, Zhihong Shen, Yang Che   +9 more
wiley   +1 more source

Additional file 1 of A 192 bp ERV fragment insertion in the first intron of porcine TLR6 may act as an enhancer associated with the increased expressions of TLR6 and TLR1

, 2021
Additional file 1: Table S1. Predicted Structural variations (SVs) of pig TLRs. Table S2 Number and origin of pig breeds for TLRs RIPs detection. Table S3 The primers for PCR, vectors construction and q-PCR.
Wang, XiaoYan, Chen, Zixuan, Murani, Eduard, D’Alessandro, Enrico, An, Yalong, Chen, Cai, Li, Kui, Galeano, Grazia, Wimmers, Klaus, Song, Chengyi   +9 more
openaire   +1 more source

TLR6 transcript, protein and function during hypoxia.

, 2013
A and B, Quantification of TLR6 transcripit levels in freshly purified blood DCs, MM6 cells, confluent HMEC-1 monolayers and confluent Caco-2 monolayers. Cells were exposed to normoxia and hypoxia for indicated time points.
Julio C. Morote-Garcia (37608), Peter Rosenberger (37609), Holger K. Eltzschig (37610), Johannes Kuhlicke (37606), Julia S. Frick (37607)   +4 more
core   +1 more source

Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap data.

PLoS ONE, 2012
Genetic epidemiological studies of complex diseases often rely on data from the International HapMap Consortium for identification of single nucleotide polymorphisms (SNPs), particularly those that tag haplotypes.
Allison R Baker, Feiyou Qiu, April Kaur Randhawa, David J Horne, Mark D Adams, Muki Shey, Jill Barnholtz-Sloan, Harriet Mayanja-Kizza, Gilla Kaplan, Willem A Hanekom, W Henry Boom, Thomas R Hawn, Catherine M Stein, Tuberculosis Research Unit and South African Tuberculosis Vaccine Initiative Team   +13 more
doaj   +1 more source

TLR-dependent control of Francisella tularensis infection and host inflammatory responses. [PDF]

PLoS ONE, 2009
BACKGROUND:Francisella tularensis is the causative agent of tularemia and is classified as a Category A select agent. Recent studies have implicated TLR2 as a critical element in the host protective response to F.
Allison L Abplanalp, Ian R Morris, Bijaya K Parida, Judy M Teale, Michael T Berton   +4 more
doaj   +1 more source

Mycoplasma Contamination Alters the Expression Profile of Pro‐Inflammatory Cytokines by Human Innate Immune Cells

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT The impact of Mycoplasma contaminations on in vitro test systems has been extensively discussed and in vitro studies have demonstrated various effects on the physiology of the contaminated cell line. Thus far, little is known about the effect of biologically active substances, such as viruses produced in contaminated cell lines on primary ...
Patricia Gogesch, Stefanie Kronhart, Marc A. Niles, Georg Kochs, Zoe Waibler, Martina Anzaghe   +5 more
wiley   +1 more source

miR-124 targets TLR6 mRNA.

, 2014
TLR6 mRNA and protein was detected by a qRT-PCR (top panels) or an immunoblotting assay (bottom panels), respectively in naïve A549 cells (A) or cells infected with BCG (B).
Yong Li (15029), Xiaoming Liu (47653), Yujiong Wang (547510), Chunyan Ma (170758), Xiaoling Wu (547509), Jin Zeng (196246)   +5 more
core   +1 more source

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Central role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Stuti Agarwal, Anuradha Bankar, Vinicio A. de Jesus Perez   +2 more
wiley   +1 more source

Dengue virus NS1 protein activates immune cells via TLR4 but not TLR2 or TLR6 [PDF]

Immunology & Cell Biology, 2017
The secreted hexameric form of the dengue virus (DENV) non‐structural protein 1 (NS1) has recently been shown to elicit inflammatory cytokine release and disrupt endothelial cell monolayer integrity. This suggests that circulating NS1 contributes to the vascular leak that plays a major role in the pathology of dengue haemorrhagic fever and shock ...
Modhiran, Naphak, Watterson, Daniel, Blumenthal, Antje, Baxter, Alan G., Young, Paul R., Stacey, Katryn J.   +5 more
openaire   +5 more sources