Results 81 to 90 of about 18,028 (232)

Microbiome-gut-brain axis and toll-like receptors in parkinson\u2019s disease [PDF]

, 2018
Parkinson’s disease (PD) is a progressively debilitating neurodegenerative disease characterized by α-synucleinopathy, which involves all districts of the brain-gut axis, including the central, autonomic and enteric nervous systems.
Caputi, Valentina, Giron, Maria Cecilia
core   +2 more sources

Novel sequence variants in the TLR6 gene associated with advanced breast cancer risk in the Saudi Arabian population

PLoS ONE, 2018
Herein, we evaluated the association of the Toll-like receptor 6 (TLR6) single nucleotide polymorphisms (SNPs) rs3796508 (Val327Met) and rs5743810 (Ser249Pro) with breast cancer (BC) susceptibility in Saudi Arabian women, using in silico analysis.
A. Semlali, M. Almutairi, M. Rouabhia, Narasimha Reddy Parine, Abdullah Al Amri, Nouf S. Al-Numair, Yousef M. Hawsawi, Mohammad Saud Alanazi   +7 more
semanticscholar   +1 more source

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, EarlyView.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Sequence Variants in Toll-Like Receptor Gene Cluster (TLR6-TLR1-TLR10) and Prostate Cancer Risk [PDF]

JNCI Journal of the National Cancer Institute, 2005
Chronic inflammation plays an important role in several human cancers and may be involved in the etiology of prostate cancer. Toll-like receptors (TLRs) are important in the innate immune response to pathogens and in cross-talk between innate immunity and adaptive immunity.
Jielin, Sun, Fredrik, Wiklund, S Lilly, Zheng, Baoli, Chang, Katarina, Bälter, Liwu, Li, Jan-Erik, Johansson, Ge, Li, Hans-Olov, Adami, Wennuan, Liu, Amy, Tolin, Aubrey R, Turner, Deborah A, Meyers, William B, Isaacs, Jianfeng, Xu, Henrik, Grönberg   +15 more
openaire   +2 more sources

Determination of Genetic Variations of Toll-Like Receptor (TLR) 2, 4, and 6 with Next-Generation Sequencing in Native Cattle Breeds of Anatolia and Holstein Friesian

Diversity, 2016
In recent years, the focus of disease resistance and susceptibility studies in cattle have been on determining patterns in the innate immune response of key proteins, such as Toll-like receptors (TLR).
Nuket Bilgen, Bengi Cinar Kul, Victoria Offord, Dirk Werling, Okan Ertugrul   +4 more
doaj   +1 more source

Haplotype Disequilibrium in the TLR Genes of Czech Red Pied Cattle

Diversity, 2023
Hybrid resequencing of the antibacterial innate immune genes coding for toll-like receptors, namely TLR1, TLR2, TLR4, TLR5, and TLR6, using HiSeq and PacBio technologies of pooled population samples of Czech Simmental (Czech Red) cattle allowed us to ...
Kalifa Samaké, Karel Novák
doaj   +1 more source

Novel mutations in the toll like receptor genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection [PDF]

, 2008
Toll like receptors play a central role in the recognition of pathogen associated molecular patterns (PAMPs). Mutations in TLR1, TLR2 and TLR4 genes may change the PAMP reorganization ability which causes altered responsiveness to the bacterial pathogens.
Ivan Mikula Jr., Ivan Mikula Sr., Lucia Kisova, Mangesh Bhide, Michal Novak, Rastislav Mucha, Rostislav Skrabana   +6 more
core   +1 more source

RNA expression of TLR10 in normal equine tissues [PDF]

, 2016
Background: Toll like receptors are one of the major innate immune system pathogen recognition systems. There is little data on the expression of the TLR10 member of this family in the horse.
A Mortazavi, AH Werners, AM Quintana, BS Leise, CM Seabury, CM Wade, D Schneberger, Grazieli Maboni, H Shinkai, J Moreton, JC Roach, JM Senior, Joanna Moreton, JS Chang, K Brown, L Frellstedt, Lauren Alder, M Oosting, MA Laat de, MA Opsal, MD Figueiredo, MH Kogut, MJ Mulla, N Fitzner, NM Astakhova, Rachael E. Tarlinton, RG Govindaraj, Richard D. Emes, S Fleige, S Kwon, SA Bustin, Sabine Tötemeyer, SM Kanzok, T Chuang, T Regan, T Requena, U Hasan, V Hornung, Y Guan, YW Zhang   +39 more
core   +1 more source

The interaction between farming/rural environment and TLR2, TLR4, TLR6 and CD14 genetic polymorphisms in relation to early- and late-onset asthma

Scientific Reports, 2017
Asthma phenotypes based on age-of-onset may be differently influenced by the interaction between variation in toll-like receptor (TLR)/CD14 genes and environmental microbes.
M. Lau, S. Dharmage, J. Burgess, Aung Ko Win, A. Lowe, C. Lodge, J. Perret, J. Hui, P. Thomas, S. Morrison, G. Giles, J. Hopper, M. Abramson, E. Walters, M. Matheson   +14 more
semanticscholar   +1 more source