Results 91 to 100 of about 10,412 (198)

Determinants of innate immune responses to mycobacteria [PDF]

, 2012
Includes bibliographical references.Innate cells such as macrophages, monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers.
Shey, Muki Shehu
core   +1 more source

Dysregulation of Toll-Like Receptor Signaling-Associated Gene Expression in X-Linked Agammaglobulinemia: Implications for Correlations Genotype-Phenotype and Disease Expression

Journal of Innate Immunity
Introduction: In X-linked agammaglobulinemia (XLA), the diversity of BTK variants complicates the study of genotype-phenotype correlations. Since BTK negatively regulates toll-like receptors (TLRs), we investigated if distinct BTK mutation types ...
Marcelo Teocchi, Thaís de Andrade Eugênio, Lia Furlaneto Marega, Isabella Quinti, Maria Marluce dos Santos Vilela   +4 more
doaj   +1 more source

Hirudin Attenuates Uric Acid‐Induced Renal Tubular Injury via TNFRSF6B‐Mediated Suppression of NF‐κB Signaling

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Hyperuricemia, characterized by elevated serum uric acid (SUA) levels, is increasingly recognized as a pathological contributor to renal injury through oxidative stress, inflammation, and apoptosis. Hirudin, a thrombin inhibitor derived from leech saliva, has recently been noted for its anti‐inflammatory properties, yet its role in ...
Yingxue Zhao, Yongjie Qin, Lanzhi He, Haikun Luo, Ying Mo, Weihai Zhou, Huamei He, Ganping Zhou, Xihua Liu   +8 more
wiley   +1 more source

Protective Association of TLR6 rs5743810 with Pulmonary Tuberculosis in the Population of JAMMU Region

Indian Journal of Microbiology
Tuberculosis (TB) is an international public health problem that results in preventable deaths each year. About 10% of those infected develop tuberculosis, indicating that host defense factors play a significant role in the progression to active disease. Polymorphic variants in the genes determine genetic diversity among populations.
Sakshi Sharma, Indu priya, Isar Sharma, Suruchi Gupta, Rahul Gupta, Ritu Mahajan, Nisha Kapoor   +6 more
openaire   +2 more sources

Polymorphisms inTLR1, TLR6andTLR10genes and the risk of Graves’ disease

Autoimmunity, 2014
Graves' disease (GD) is postulated to be caused by the combined effects of susceptibility genes and environmental triggers. Toll-like receptors (TLRs) play a role in the activation of innate and adaptive immune responses in mammalians. The aim of this study was to evaluate the potential association of polymorphisms in TLR1, TLR6 and TLR10 genes with GD
WenJuan, Xiao, ZeLin, Liu, JiangHai, Lin, JingBo, Li, KeJing, Wu, Yun, Ma, YingXue, Gong, ZeHuan, Liu   +7 more
openaire   +2 more sources

DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF MICROBIAL COMPONENT SENSOR GENES TLR1 AND TLR6 IN MAJOR POPULATIONS OF SOUTH URALS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
Aim. Evaluate the fraction of various TLR1-TLR6 haplotypes in populations of Russians, Bashkir and Nagaybak of Chelyabinsk Region. Materials and methods.
A. L Burmistrova, A. V Evdokimov, D. S Stashkevich, Yu. Yu Filippova, T. A Suslova   +4 more
doaj  

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar, Joanna Razafiarison, Fawaz Alzaid, Fahd Al‐Mulla, Rasheed Ahmad   +4 more
wiley   +1 more source

Japanese Encephalitis Virus and Host Innate Immunity: Insights Into TLR Signaling, PRR Crosstalk, and Viral Immune Evasion

Cell Biochemistry and Function, Volume 44, Issue 7, July 2026.
ABSTRACT Japanese encephalitis virus (JEV), a neurotropic flavivirus and a major cause of viral encephalitis, poses a significant global health threat due to its neuroinvasive potential. Host innate immune responses, particularly those mediated by pattern‐recognition receptors such as Toll‐like receptors (TLRs) and RIG‐I–like receptors, play critical ...
Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama‐Kohara   +2 more
wiley   +1 more source

Dietary Supplementation of Rumen‐Inert Fatty Acids and Rumen‐Protected Choline Modulates the Uterine Environment of Pregnant Beef Cows

Molecular Reproduction and Development, Volume 93, Issue 7, July 2026.
This graphical abstract summarizes that dietary supplementation of pregnant beef cows with unsaturated fatty acids and choline can increase (green) the concentration of metabolites in the uterine luminal fluid and alter the endometrial epithelial transcriptome during the peri‐elongation period (upregulation = green and downregulation = red).
Megan Bahr, Allyson McCarty, Zaeem Sarwar, Damon Smith, Matt Poore, Daniel Poole, Nadia Ashrafi, Romana Mimi, Stewart Graham, Ky Pohler, Jose Santos, Christian Maltecca, Felipe A. C. C. Silva   +12 more
wiley   +1 more source

Comparisons of DNA methylation levels over the TLR2 promoter region, TLR6 gene body, and protein expressions of TLR2 and TLR6 between non-EDS and EDS groups.

, 2020
(A)~(D) The DNA methylation levels over the TLR2 promoter region, and protein expressions of TLR2 and TLR6 were not significantly different except that CpG site #2 of the TLR6 gene body was hypermethylated significantly in the EDS group (p = .032).
Chang-Chun Hsiao (381914), Chia-Cheng Tseng (598324), Huang-Chih Chang (598326), Meng-Chih Lin (162902), Yung-Che Chen (381913), Kuo-Tung Huang (598325), Yong-Yong Lin (4030910), Jen-Chieh Chang (381921), Chien-Hung Chin (4030907), Mao-Chang Su (33430), Ting-Ya Wang (381920), Yi-Xin Zheng (4030904)   +11 more
core   +1 more source