Results 91 to 100 of about 18,028 (232)

Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis, Andrea Nüesch, Joseph Snuggs, Christine Lyn Le Maitre, Leonidas G. Alexopoulos   +4 more
wiley   +1 more source

Sexual dimorphisms in leukocyte trafficking in a mouse peritonitis model [PDF]

, 2016
E.K was funded by the British Heart Foundation Grant # FS113028789 and JRW was funded by Arthritis Research-UK Grant ...
Gomez-Garcia, L, Kay, E, Scotland, RS, Whiteford, JR, Woodfin, A   +4 more
core   +1 more source

Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System

European Journal of Immunology, Volume 56, Issue 5, May 2026.
Integrated overview of host defense and immune evasion in Lyme Borreliosis. Bbsl evades immunity through tick saliva‐mediated suppression of innate defenses, TLR2/NOD2‐driven cytokine dysregulation, and interference with JAK/STAT and CIITA‐dependent antigen presentation.
Zara Karami, Hadewych J. M. ter Hofstede, Leo A. B. Joosten   +2 more
wiley   +1 more source

Association of Toll-like receptor polymorphism and gene expression level with the risk of developing chronic obstructive pulmonary disease (COPD) and its severity

Бюллетень сибирской медицины
Aim. Determine the influence of genetic factors of innate immunity on the risk of development and severity of COPD. Materials and methods. The study included 103 patients diagnosed with chronic obstructive pulmonary disease and 47 conditionally healthy ...
S. A. Salamaikina, V. I. Korchagin, K. O. Mironov, M. A. Karnaushkina   +3 more
doaj   +1 more source

TLRs and Bcl-2 family proteins in neutrophils of oral cavity cancer patients.

Folia Histochemica et Cytobiologica, 2010
Human neutrophils (PMNs), the cells engaged in the early phase of anti-tumor response, express TLR2 and TLR6 that can modulate the Bcl-2 family proteins, regulating the intrinsic apoptotic pathway in these cells.
Marzena Garley, Ewa Jablonska
doaj   +1 more source

Толл-подобные рецепторы, активируемые бактериальными лигандами, в патогенезе неразвивающейся беременности и самопроизвольных выкидышей [PDF]

, 2018
Статья посвящена исследованию роли Толл-подобных рецепторов (TLR), активируемых бактериальными лигандами, в патогенезе неразвивающейся беременности и самопроизвольных выкидышей ранних сроков.
Жукова, И. О., Ивашова, О. Н., Лебедева, О. П., Пахомов, С. П.   +3 more
core   +2 more sources

Lesion size is associated with genetic polymorphisms in TLR1, TLR6, and TIRAP genes in patients with major abscesses and diabetic foot infections

European Journal of Clinical Microbiology and Infectious Diseases, 2019
Genetic variation in Toll-like receptors (TLRs) has previously been associated with susceptibility to complicated skin and skin structure infections (cSSSIs).
Valentino D'onofrio, Annelie A. Monnier, C. Kremer, M. Stappers, M. Netea, I. Gyssens   +5 more
semanticscholar   +1 more source

Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses ...
Lauren Jirik, Shreya Joshi, Aisha Nazli, Charu Kaushic   +3 more
wiley   +1 more source

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

ChemistryEurope, Volume 4, Issue 4, April 2026.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn, Giulia Castello, Nico J. Meeuwenoord, Martijn Verdoes, Jeroen D. C. Codée, Ferry Ossendorp, Dmitri V. Filippov   +6 more
wiley   +1 more source

Surface-Expressed TLR6 Participates in the Recognition of Diacylated Lipopeptide and Peptidoglycan in Human Cells [PDF]

The Journal of Immunology, 2005
Abstract Recognition of microbial components by TLR2 requires cooperation with other TLRs. TLR6 has been shown to be required for the recognition of diacylated lipoproteins and lipopeptides derived from mycoplasma and to activate the NF-κB signaling cascade in conjunction with TLR2.
Yoshiya, Nakao, Kenji, Funami, Satomi, Kikkawa, Mitsue, Taniguchi, Miyuki, Nishiguchi, Yasuhiro, Fukumori, Tsukasa, Seya, Misako, Matsumoto   +7 more
openaire   +2 more sources