Results 111 to 120 of about 18,028 (232)

Comparative Transcriptomic Analysis of Human Macrophages During Mycobacterium avium Versus Mycobacterium tuberculosis Infection

Molecular Microbiology, Volume 125, Issue 3, Page 185-202, March 2026.
Human macrophage transcriptomic responses to Mycobacterium avium (Mav), a major cause of nontuberculous lung disease, were compared to Mycobacterium tuberculosis (Mtb). Both infections activated overlapping immune pathways, including cytokine signaling and GPCRs involved in lipid metabolism, while phospholipases were more strongly regulated by Mav and ...
Gül Kilinç, Robin H. G. A. van den Biggelaar, Tom H. M. Ottenhoff, Leon H. Mei, Anno Saris   +4 more
wiley   +1 more source

Dysregulation of Toll-Like Receptor Signaling-Associated Gene Expression in X-Linked Agammaglobulinemia: Implications for Correlations Genotype-Phenotype and Disease Expression

Journal of Innate Immunity
Introduction: In X-linked agammaglobulinemia (XLA), the diversity of BTK variants complicates the study of genotype-phenotype correlations. Since BTK negatively regulates toll-like receptors (TLRs), we investigated if distinct BTK mutation types ...
Marcelo Teocchi, Thaís de Andrade Eugênio, Lia Furlaneto Marega, Isabella Quinti, Maria Marluce dos Santos Vilela   +4 more
doaj   +1 more source

TLRs, future potential therapeutic targets for RA [PDF]

, 2017
Toll like receptor (TLR)s have a central role in regulating innate immunity and in the last decade studies have begun to reveal their significance in potentiating autoimmune diseases such as rheumatoid arthritis (RA).
Elshabrawy, Hatem A., Essani, Abdul E., Fox, David A., Shahrara, Shiva, Szekanecz, Zoltán   +4 more
core   +1 more source

Crosstalk Between Intratumoral Microbes and Tumor Immunity: Implications for Tumor Therapy

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Emerging studies indicate that microbes are present in tumor cells and immune cells. Intratumoral microbiota (ITM) constitute an important component of the tumor immune microenvironment (TIME) and have an important impact on tumor progression and treatment. Objective Through the general elaboration of ITM represented by bacteria and
Fengxue Li, Lili Qiao, Xinquan Liang, Yingying Zhang, Ning Liang, Jian Xie, Guodong Deng, Yuying Hao, Pingping Hu, Xue Wu, Fangjie Ding, Can Feng, Yiming Mu, Jiandong Zhang   +13 more
wiley   +1 more source

DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF MICROBIAL COMPONENT SENSOR GENES TLR1 AND TLR6 IN MAJOR POPULATIONS OF SOUTH URALS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
Aim. Evaluate the fraction of various TLR1-TLR6 haplotypes in populations of Russians, Bashkir and Nagaybak of Chelyabinsk Region. Materials and methods.
A. L Burmistrova, A. V Evdokimov, D. S Stashkevich, Yu. Yu Filippova, T. A Suslova   +4 more
doaj  

Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells [PDF]

, 2015
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.Mechanical ventilation (MV) of patients can cause
Gudjonsson, Thorarinn, Gudmundsson, Gudmundur Hrafn, Karadottir, Harpa, Karason, Sigurbergur, Kulkarni, Nikhil Nitin   +4 more
core   +3 more sources

MALP-2, an agonist of TLR6, promotes the immune status without affecting the differentiation capacity of umbilical cord mesenchymal stem cells.

Experimental and Therapeutic Medicine, 2017
Mesenchymal stem cells (MSCs) are increasingly used in cell-based therapy due to their multiple differentiation capacity, low expression of co-stimulatory factors and immunosuppressive effect.
Xiuli Wu, Lian Xu, Yangmei Shen, Na Yu, Yan Zhang, Tao Guo   +5 more
semanticscholar   +1 more source

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
wiley   +1 more source

Endometrial Microbiome and Implantation: From Basic Knowledge to Clinical Medicine

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Background Recurrent implantation failure (RIF) is an infertility condition in which uterine factors remain difficult to diagnose and treat. Recent studies implicate the endometrial microbiome in implantation. Methods This clinically oriented narrative review summarizes female reproductive tract microbiota and evidence on endometrial ...
Daiki Hiratsuka, Mitsunori Matsuo, Yasushi Hirota   +2 more
wiley   +1 more source

Iron‐related intercellular communication in the liver: Main players and mechanisms

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Iron exchange between liver cell types is vital for organism health, yet its mechanisms remain poorly understood. In this review, we address intercellular communication governing hepatic iron regulation across different liver diseases. We summarize recent insights into how hepatocytes, macrophages, endothelial and stellate cells coordinate iron storage,
Óscar Fonseca, Paulo J. Oliveira, Martina U. Muckenthaler, Ana C. Moreira, M. Salomé Gomes   +4 more
wiley   +1 more source