Results 71 to 80 of about 9,070 (169)

Dysregulation of Toll-Like Receptor Signaling-Associated Gene Expression in X-Linked Agammaglobulinemia: Implications for Correlations Genotype-Phenotype and Disease Expression

Journal of Innate Immunity
Introduction: In X-linked agammaglobulinemia (XLA), the diversity of BTK variants complicates the study of genotype-phenotype correlations. Since BTK negatively regulates toll-like receptors (TLRs), we investigated if distinct BTK mutation types ...
Marcelo Teocchi, Thaís de Andrade Eugênio, Lia Furlaneto Marega, Isabella Quinti, Maria Marluce dos Santos Vilela   +4 more
doaj   +1 more source

Association of TLR6 gene polymorphisms with zootechnical parameters in Holstein cattle in northern Antioquia

Revista Facultad Nacional de Agronomía Medellín, 2017
Specialized dairy systems are one of the most important lines in the agricultural sector in Colombia and the world. Currently there are strategies, both of environmental management and animal breeding, seeking to optimize the production.
Juan Pablo Arismendy Morales, Albeiro López Herrera, Julián Echeverri Zuluaga   +2 more
doaj   +1 more source

Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis, Andrea Nüesch, Joseph Snuggs, Christine Lyn Le Maitre, Leonidas G. Alexopoulos   +4 more
wiley   +1 more source

Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6

Gastric Cancer
AbstractHelicobacter pylori (H. pylori, Hp) has been designated a class I carcinogen and is closely associated with severe gastric diseases. During colonization in the gastric mucosa, H. pylori develops immune escape by inducing host immune tolerance. The gastric epithelium acts as the first line of defense against H.
Xiulin Zhang, Yulong He, Xiaolu Zhang, Bo Fu, Zidai Song, Wei Wang, Rui Fu, Xuancheng Lu, Xing Jin, Jing Lv, Meng Guo, Xueyun Huo, Xin Liu, Jiarui Lu, Xiaoyan Du, Zhongming Ge, Zhenwen Chen, Changlong Li   +17 more
openaire   +4 more sources

DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF MICROBIAL COMPONENT SENSOR GENES TLR1 AND TLR6 IN MAJOR POPULATIONS OF SOUTH URALS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
Aim. Evaluate the fraction of various TLR1-TLR6 haplotypes in populations of Russians, Bashkir and Nagaybak of Chelyabinsk Region. Materials and methods.
A. L Burmistrova, A. V Evdokimov, D. S Stashkevich, Yu. Yu Filippova, T. A Suslova   +4 more
doaj  

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, Volume 2, Issue 2, Page 236-279, June 2026.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, Volume 293, Issue 11, Page 3187-3210, June 2026.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System

European Journal of Immunology, Volume 56, Issue 5, May 2026.
Integrated overview of host defense and immune evasion in Lyme Borreliosis. Bbsl evades immunity through tick saliva‐mediated suppression of innate defenses, TLR2/NOD2‐driven cytokine dysregulation, and interference with JAK/STAT and CIITA‐dependent antigen presentation.
Zara Karami, Hadewych J. M. ter Hofstede, Leo A. B. Joosten   +2 more
wiley   +1 more source

Association of Toll-like Receptors 1, 2, 4, 6, 8, 9 and 10 Genes Polymorphisms and Susceptibility to Pulmonary Tuberculosis in Sudanese Patients

ImmunoTargets and Therapy, 2023
Najwa A Mhmoud Faculty of Medical Laboratory Sciences, Department of Medical Microbiology and Immunology, University of Khartoum, Khartoum, SudanCorrespondence: Najwa A Mhmoud, Faculty of Medical Laboratory Sciences, Department of Medical Microbiology ...
Mhmoud NA
doaj  

Arctigenin Induces an Activation Response in Porcine Alveolar Macrophage Through TLR6-NOX2-MAPKs Signaling Pathway

Frontiers in Pharmacology, 2018
Arctigenin (ARG), one of the most active ingredients abstracted from seeds of Arctium lappa L., has been proved to exert promising biological activities such as immunomodulatory, anti-viral, and anti-cancer etc.
Zheng Lu, Lingling Chang, Qian Du, Yong Huang, Xiujuan Zhang, Xingchen Wu, Jie Zhang, Ruizhen Li, Zelin Zhang, Wenlong Zhang, Xiaomin Zhao, Dewen Tong   +11 more
doaj   +1 more source