Results 1 to 10 of about 65,188 (262)
IRAP+ endosomes restrict TLR9 activation and signaling [PDF]
Nature Immunology, 2017 The retention of intracellular Toll-like receptors (TLRs) in the endoplasmic reticulum prevents their activation under basal conditions. TLR9 is activated by sensing ligands in specific endosomal-lysosomal compartments. Here we identified IRAP+ endosomes as major cellular compartments for the early steps of TLR9 activation in dendritic cells (DCs ...
Delphyne Descamps +2 more
exaly +7 more sources
TLR9 signaling requires ligand-induced phosphorylation of two specific tyrosine residues by EGFR and Syk [PDF]
mBioToll-like receptors (TLRs) are transmembrane proteins that recognize microbial components or cellular danger signals and activate intracellular signaling pathways, leading to induction of anti-microbial and inflammatory genes.
Manoj Veleeparambil +8 more
doaj +2 more sources
Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice
Nature CommunicationsToll-like receptor 9 (TLR9) recognizes self-DNA and plays intricate roles in systemic lupus erythematosus (SLE). However, the molecular mechanism regulating the endosomal TLR9 response is incompletely understood.
Hai Ni, Jijun Zhao, Cliff Y Yang
exaly +2 more sources
Blocking Toll-like receptor 9 attenuates bleomycin-induced pulmonary injury [PDF]
Journal of Pathology and Translational Medicine, 2022 Background Acute respiratory distress syndrome (ARDS) is one of the most common complications in coronavirus disease 2019 patients suffering from acute lung injury (ALI). In ARDS, marked distortion of pulmonary architecture has been reported.
Badr Alzahrani +5 more
doaj +1 more source
TLR9 gene expression in immune cells of patients with psoriasis
Consilium Medicum, 2022 Background. Psoriasis (skin lesions and psoriatic arthritis PA) is a chronic inflammatory autoimmune disease that can be triggered by excessive activation of endosomal toll-like receptors (TLRs), mainly TLR9. Elevated TLR9 levels are observed in both PA
Svetlana N. Chebysheva +5 more
doaj +1 more source
Expression of TLR9 and NF-κB in condyloma acuminatum
Pifu-xingbing zhenliaoxue zazhi, 2021 Objective To explore the expression and significance of TLR9 and NF-κB in condyloma acuminatum (CA). Methods The streptavidin-peroxidase (SP) immunohistochemistry method was used to measure the expression of TLR9 and NF-κB in 50 cases of CA and 20 normal
Guangwen YIN +4 more
doaj +1 more source
Immunocytochemical characteristic of the endometrial mucosa HIV-infected women [PDF]
Гинекология, 2020 Relevance. Human immunodeficiency virus (HIV) infection is an independent factor in reduced fertility and a risk factor for miscarriage. There are some date an endometrial receptivity of HIV-infected patients has changed that plays an important role in ...
Irina N. Vorobtsova +5 more
doaj +1 more source
Mechanisms of TLR9 activation [PDF]
Journal of Endotoxin Research, 2004 Non-methylated CpG-motifs in bacterial or viral DNA are recognized by TLR9 as foreign. The activation of TLR9 by microbial DNA or synthetic oligonucleotides based on these motifs leads to the induction of innate immune responses. We have compared the subcellular localization of fluorescent versions of TLR9 and TLR4 and found that TLR9 is expressed in ...
Eicke, Latz +3 more
openaire +2 more sources
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. [PDF]
, 2008 Mammalian Toll-like receptors (TLRs) 3, 7, 8 and 9 initiate immune responses to infection by recognizing microbial nucleic acids; however, these responses come at the cost of potential autoimmunity owing to inappropriate recognition of self nucleic acids.
Barton, Gregory M +6 more
core +5 more sources
The role of Toll-like receptors in chemoradiotherapy-induced gastrointestinal mucositis
口腔疾病防治, 2021 Mucositis is a common gastrointestinal complication in cancer patients undergoing chemoradiotherapy, including oral mucositis and gastrointestinal mucositis, with clinical manifestations of oral ulcers, vomiting, diarrhea and pain that seriously reduce ...
JI Ling +3 more
doaj +1 more source