Results 31 to 40 of about 46,527 (261)
TLR9−/− and TLR9+/+ mice display similar immune responses to a DNA vaccine [PDF]
Immunology, 2004 SummaryPlasmid DNA continues to attract interest as a potential vaccine‐delivery vehicle. However, the mechanisms whereby immune responses are elicited by plasmids are not fully understood. Although there have been suggestions regarding the importance of CpG motifs in plasmid immunogenicity, the molecular mechanisms by which CpG motifs enhance immune ...
Shawn, Babiuk +6 more
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, 2019 A and B) For batch mode, reaction was performed for 3h at 30°C. A and C) For CECF mode, reaction was performed using optimized conditions (see previous sections). Optimal conditions were: 48h reaction time and 30°C reaction temperature.
Lena Thoring (3185994) +4 more
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Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells. [PDF]
PLoS ONE, 2011 Plasmacytoid dendritic cells (pDCs) play a key role in detecting pathogens by producing large amounts of type I interferon (IFN) by sensing the presence of viral infections through the Toll-Like Receptor (TLR) pathway.
Isabelle E Vincent +10 more
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Toll-like receptor 9 mediated responses in cardiac fibroblasts. [PDF]
PLoS ONE, 2014 Altered cardiac Toll-like receptor 9 (TLR9) signaling is important in several experimental cardiovascular disorders. These studies have predominantly focused on cardiac myocytes or the heart as a whole.
Ingrid Kristine Ohm +9 more
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Sensing the hybrid—a novel PAMP for TLR9 [PDF]
The EMBO Journal, 2014 The host immune response is initiated by pattern recognition receptors (PRR) when triggered by specific ligands known as pathogen-associated molecular patterns (PAMP). Toll-like receptor 9 is highly expressed in plasmacytoid dendritic cells and is well described as a PRR for CpG DNA which induce the production of cytokines and type I interferons.
Søren B, Jensen, Søren R, Paludan
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Protective effect of TLR2/TLR9 agonists on pulmonary Acinetobacter baumannii infection in mice
陆军军医大学学报Objective To investigate the protective effect of Toll-like receptor (TLR) 2 /TLR9 agonists, Pam2CSK4 (Pam) and CpG ODN (CpG) on mice infected with Acinetobacter baumannii (Ab) in the lungs.
CHENG Hao, YANG Yun, SUN Hongwu
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Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA
Frontiers in Immunology, 2018 Mouse toll-like receptor 9 (TLR9) is an endosomal sensor for single-stranded DNA. TLR9 is transported from the endoplasmic reticulum to endolysosomes by a multiple transmembrane protein Unc93 homolog B1, and proteolytically cleaved at its ectodomain. The
Ryutaro Fukui +13 more
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The regulatory capacity of B cells directs the aggressiveness of CLL
OncoImmunology, 2019 Chronic lymphocytic leukemia (CLL) is associated with abnormal T-cell responses responsible for defective anti-tumor activities. Intriguingly, CLL B cells share phenotypical characteristics with regulatory B (Breg) cells suggesting that they might ...
Audrey Mohr +12 more
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Toll-like receptor 9 is required for opioid-induced microglia apoptosis. [PDF]
PLoS ONE, 2011 Opioids have been widely applied in clinics as one of the most potent pain relievers for centuries, but their abuse has deleterious physiological effects beyond addiction.
Lei He +12 more
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Was Induction of HIV-1 Through TLR9? [PDF]
The Journal of Immunology, 2003 Equils et al. ([1][1]) reported implication of simultaneous activation of Toll-like receptors (TLRs) on HIV replication. When spleen cells from HIV-1 transgenic mice were exposed to agonists of TLR2, TLR4, and TLR9, p24 production was induced.
Sudhir, Agrawal, R Russell, Martin
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