Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance. [PDF]
, 2020 Stromal-epithelial interactions dictate cancer progression and therapeutic response. Prostate cancer (PCa) cells were identified to secrete greater concentration of mitochondrial DNA (mtDNA) compared to noncancer epithelia.
Agarwal, Priyanka +11 more
core
How mucosal epithelia deal with stress: Role of NKG2D/NKG2D ligands during inflammation [PDF]
, 2017 Mucosal epithelia encounter both physicochemical and biological stress during their life and have evolved several mechanisms to deal with them, including regulation of immune cell functions.
Alessandra Soriani +5 more
core +2 more sources
Drug Design, Development and Therapy, 2021 Qingling Guo,1,2 Haili Qu,3 Hong Zhang,4 Xia Zhong4 1Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, People’s Republic of China; 2Department of Endocrinology, Shandong Provincial ...
Guo Q, Qu H, Zhang H, Zhong X
doaj
Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice. [PDF]
PLoS ONE, 2017 Genetic deficiency in TLR9 accelerates pathogenesis in the spontaneous polygenic MRL.Faslpr murine model of systemic lupus erythematosus, despite the absence of anti-nucleosome autoantibodies. However, it could be argued that this result was dependent on
Kevin M Nickerson +3 more
doaj +1 more source
Chicken Toll-like Receptor 3 Recognizes Its Cognate Ligand When Ectopically Expressed in Human Cells [PDF]
, 2007 Recognition of pathogens by toll-like receptors (TLRs) causes activation of signaling cascades that trigger cytokine secretion and, ultimately, innate immunity.
Bauer, Stefan +7 more
core +1 more source
TLR9−/− and TLR9+/+ mice display similar immune responses to a DNA vaccine [PDF]
Immunology, 2004 SummaryPlasmid DNA continues to attract interest as a potential vaccine‐delivery vehicle. However, the mechanisms whereby immune responses are elicited by plasmids are not fully understood. Although there have been suggestions regarding the importance of CpG motifs in plasmid immunogenicity, the molecular mechanisms by which CpG motifs enhance immune ...
Shawn, Babiuk +6 more
openaire +2 more sources
Targeting STAT3 in Cancer with Nucleotide Therapeutics. [PDF]
, 2019 Signal transducer and activator of transcription 3 (STAT3) plays a critical role in promoting the proliferation and survival of tumor cells. As a ubiquitously-expressed transcription factor, STAT3 has commonly been considered an "undruggable" target for ...
Grandis, Jennifer R +3 more
core +2 more sources
Toll-like receptor 9 is required for opioid-induced microglia apoptosis. [PDF]
PLoS ONE, 2011 Opioids have been widely applied in clinics as one of the most potent pain relievers for centuries, but their abuse has deleterious physiological effects beyond addiction.
Lei He +12 more
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Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA
Frontiers in Immunology, 2018 Mouse toll-like receptor 9 (TLR9) is an endosomal sensor for single-stranded DNA. TLR9 is transported from the endoplasmic reticulum to endolysosomes by a multiple transmembrane protein Unc93 homolog B1, and proteolytically cleaved at its ectodomain. The
Ryutaro Fukui +13 more
doaj +1 more source
Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells. [PDF]
PLoS ONE, 2011 Plasmacytoid dendritic cells (pDCs) play a key role in detecting pathogens by producing large amounts of type I interferon (IFN) by sensing the presence of viral infections through the Toll-Like Receptor (TLR) pathway.
Isabelle E Vincent +10 more
doaj +1 more source