Results 31 to 40 of about 38,400 (238)
Polymorphisms and expression of toll-like receptors in autoimmune thyroid diseases
Autoimmunity, 2017 Graves’ disease (GD) and Hashimoto’s disease (HD) are autoimmune thyroid diseases (AITDs). Prognosis of AITDs varies in each patient. Toll-like receptors (TLRs) are pattern-recognition receptors that activate signaling pathways involved in the production
Naoya Inoue +8 more
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Transcriptional Regulation of the Human TLR9 Gene [PDF]
The Journal of Immunology, 2004 Abstract To clarify the molecular basis of human TLR9 (hTLR9) gene expression, the activity of the hTLR9 gene promoter was characterized using the human myeloma cell line RPMI 8226. Reporter gene analysis and EMSA demonstrated that hTLR9 gene transcription was regulated via four cis-acting elements, cAMP response element, 5′-PU box, 3′
Fumihiko, Takeshita +5 more
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The regulatory capacity of B cells directs the aggressiveness of CLL
OncoImmunology, 2019 Chronic lymphocytic leukemia (CLL) is associated with abnormal T-cell responses responsible for defective anti-tumor activities. Intriguingly, CLL B cells share phenotypical characteristics with regulatory B (Breg) cells suggesting that they might ...
Audrey Mohr +12 more
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Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice. [PDF]
PLoS ONE, 2017 Genetic deficiency in TLR9 accelerates pathogenesis in the spontaneous polygenic MRL.Faslpr murine model of systemic lupus erythematosus, despite the absence of anti-nucleosome autoantibodies. However, it could be argued that this result was dependent on
Kevin M Nickerson +3 more
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New vistas on TLR9 activation [PDF]
European Journal of Immunology, 2011 AbstractTogether with other reports, evidence published in this issue of the European Journal of Immunology by Avalos and Ploegh (Eur. J. Immunol. 2011. 41: 2820–2827) implies that trafficking of TLR9 from the ER to endolysosomal compartments, which is aided by the transmembrane UNC93B1 ER protein, is followed by proteolytic cleavage of the TLR9 ...
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TLR9 regulation by proteolysis: A friend or a foe [PDF]
European Journal of Immunology, 2011 AbstractIntracellular TLRs sense viral and bacterial nucleic acids from a wide variety of pathogens. Previous studies have shown that TLR9 requires processing for signalling. Following proteolysis, a fragment corresponding to the C‐terminal part of TLR9 was shown to bind MyD88 and to induce signalling when cells were stimulated with TLR9 ligands.
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Baseless Assumptions: Activation of TLR9 by DNA [PDF]
Immunity, 2008 The Toll-like receptor 9 (TLR9) is activated by DNA presented in acidified, intracellular compartments. Previous studies suggested that signaling required unmethylated CpG dinucleotides, but in this issue of Immunity, Haas et al. (2008) challenge this view, showing that DNA can activate TLR9 in a sequence-independent manner.
Gangloff, Monique, Gay, Nicholas J.
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Репродуктивная эндокринология, 2017 The aim of study. To reveal the peculiarities of mRNA expression of the inflammatory component genes of the immune response in the expected window of the implantation in women with RPL in ART programs. Material and methods.
К. П. Головатюк +4 more
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Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells. [PDF]
PLoS ONE, 2011 Plasmacytoid dendritic cells (pDCs) play a key role in detecting pathogens by producing large amounts of type I interferon (IFN) by sensing the presence of viral infections through the Toll-Like Receptor (TLR) pathway.
Isabelle E Vincent +10 more
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Toll-like receptor 9 mediated responses in cardiac fibroblasts. [PDF]
PLoS ONE, 2014 Altered cardiac Toll-like receptor 9 (TLR9) signaling is important in several experimental cardiovascular disorders. These studies have predominantly focused on cardiac myocytes or the heart as a whole.
Ingrid Kristine Ohm +9 more
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