Results 51 to 60 of about 46,527 (261)

TLR9 regulation by proteolysis: A friend or a foe [PDF]

European Journal of Immunology, 2011
AbstractIntracellular TLRs sense viral and bacterial nucleic acids from a wide variety of pathogens. Previous studies have shown that TLR9 requires processing for signalling. Following proteolysis, a fragment corresponding to the C‐terminal part of TLR9 was shown to bind MyD88 and to induce signalling when cells were stimulated with TLR9 ligands.
openaire   +5 more sources

TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients

BMC Cancer, 2010
Background Our study aims to evaluate the expression of TLR9 in glioma tissues, examine the association between TLR9 expression, clinicopathological variables, and glioma patient outcome, we further characterized the direct effects of TLR9 agonist CpG ...
Jiang Tao, Ying Qiao, Yan Ying, Cao Shouqiang, Wang Chao, Xu Ke, Wu Anhua   +6 more
doaj   +1 more source

The role of TLR9 on Leishmania amazonensis infection and its influence on intranasal LaAg vaccine efficacy. [PDF]

PLoS Neglected Tropical Diseases, 2019
Leishmania (L.) amazonensis is one of the etiological agents of cutaneous leishmaniasis (CL) in Brazil. Currently, there is no vaccine approved for human use against leishmaniasis, although several vaccine preparations are in experimental stages.
Juliana Elena Silveira Pratti, Alessandra Marcia da Fonseca Martins, Juliana Paiva da Silva, Tadeu Diniz Ramos, Joyce Carvalho Pereira, Luan Firmino-Cruz, Diogo Oliveira-Maciel, Thiago Soares de Souza Vieira, Leandra Linhares Lacerda, Andre Macedo Vale, Celio G Freire-de-Lima, Daniel C Oliveira Gomes, Elvira M Saraiva, Bartira Rossi-Bergmann, Herbert Leonel de Matos Guedes   +14 more
doaj   +1 more source

TLR9-stimulated pDCs induce a unique NK-cell phenotype and IFN-γ production.

, 2016
A–C—Phenotype analysis of NK cells following overnight stimulation with IL-15, IFN-α, or co-culture with TLR9-stimulated pDCs. Graphs represent the means of MFIs for (A) CD69, (B) TRAIL, and (C) NKG2D immunostaining, with error bars representing the ...
Martine Cordeau (3204120), Paulo Cordeiro (3204123), Hervé Sartelet (142359), Assila Belounis (3204117), Michel Duval (447435), Martin Lelaidier (3204114), Sabine Herblot (676673)   +6 more
core   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

TLR9 activation dampens the early inflammatory response to Paracoccidioides brasiliensis, impacting host survival. [PDF]

PLoS Neglected Tropical Diseases, 2013
BACKGROUND: Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P.
João Filipe Menino, Margarida Saraiva, Ana G Gomes-Alves, Diogo Lobo-Silva, Mark Sturme, Jéssica Gomes-Rezende, Ana Laura Saraiva, Gustavo H Goldman, Cristina Cunha, Agostinho Carvalho, Luigina Romani, Jorge Pedrosa, António Gil Castro, Fernando Rodrigues   +13 more
doaj   +1 more source

CD82 controls CpG-dependent TLR9 signaling.

, 2021
The tetraspanin CD82 is a potent suppressor of tumor metastasis and regulates several processes including signal transduction, cell adhesion, motility, and aggregation. However, the mechanisms by which CD82 participates in innate immunity are unknown. We
Hidde L Ploegh (9420965), Paige E Negoro (11551522), Katerina Artavanis-Tsakonas (202484), Daniel P Lukason (11551504), Michael K Mansour (11551537), Nida S Khan (11551501), Jennifer L Reedy (11551510), Shuying Xu (5577506), Eva-Maria Frickel (206815), Tammy D Vyas (11551525), Zeina Dagher (5244344), Marianela Feliu (5577509), Stuart M Levitz (11551543), Eicke Latz (416789), Rebecca A Ward (11551507), Pia V Kasperkovitz (11551519), Zaida G Ramirez-Ortiz (11551513), Mridu Acharaya (11551531), Jatin M Vyas (11551546), Christine E Becker (11551534), You-Me Kim (467484), Jenny M Tam (11551516), Melanie M Brinkmann (11551528), Allison K Lord (9644042), Cindy K Miranti (11551540)   +24 more
core   +1 more source

A Pancreatitis‐Inspired Trypsinogen Nanoplatform Reprograms Tumor‐Associated Macrophages via NF‐κB for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao, Yu He, Wenhao Li, Bo Gong, Han Lin, Jianlin Shi, Yuan Yong, Wencheng Wu   +7 more
wiley   +1 more source

Absent Toll-like receptor-9 expression predicts poor prognosis in renal cell carcinoma

Journal of Experimental & Clinical Cancer Research, 2011
Background Toll-like receptor 9 (TLR9) is a cellular DNA-receptor whose activation with cognate ligands triggers an immune reaction, with increased production of inflammatory cytokines. The aim of this study was to examine the expression of TLR9 in renal
Paavonen Timo K, Vuopala Katri S, Kauppila Saila, Hirvikoski Pasi, Ronkainen Hanna, Selander Katri S, Vaarala Markku H   +6 more
doaj   +1 more source

IRAP+ endosomes restrict TLR9 activation and signaling

, 2017
International audienceThe retention of intracellular Toll-like receptors (TLRs) in the endoplasmic reticulum prevents their activation under basal conditions. TLR9 is activated by sensing ligands in specific endosomal-lysosomal compartments.
Mauvais, Francois-Xavier, Evnouchidou, Irini, Chignard, Michel, Joel Babdor, Aimé Cézaire Adiko, Mira Tohmé, Babdor, Joël, Adiko, Aimé Cézaire, Sophia Maschalidi, Manoury, Bénédicte, Irini Evnouchidou, Francois-Xavier Mauvais, Meriem Garfa-Traore, Brinkmann, Melanie M, Descamps, Delphyne, Cézaire, Adiko Assi Aimé, Melanie M Brinkmann, Tohmé, Mira, Maschalidi, Sophia, Mariacristina De Luca, Michel Chignard, Delphyne Descamps, Bénédicte Manoury, Saveanu, Loredana, de Luca, Mariacristina, Garfa-Traore, Meriem, Vasconcellos, Luiz Ricardo, Brinkmann, Melanie, M, Brinkmann, Melanie,, Luiz Ricardo Vasconcellos, Loredana Saveanu   +30 more
core   +1 more source