Results 71 to 80 of about 38,400 (238)

The role of Toll-like receptor 9 in a murine model of Cryptococcus gattii infection

Scientific Reports, 2021
Toll-like receptor 9 (TLR9) is crucial to the host immune response against fungi, such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, but its importance in Cryptococcus gattii infection is unknown.
Elias Barbosa da Silva-Junior, Luan Firmino-Cruz, Joyce Cristina Guimarães-de-Oliveira, Juliana Valente Rodrigues De-Medeiros, Danielle de Oliveira Nascimento, Matheus Freire-de-Lima, Lycia de Brito-Gitirana, Alexandre Morrot, Jose Osvaldo Previato, Lucia Mendonça-Previato, Debora Decote-Ricardo, Herbert Leonel de Matos Guedes, Celio Geraldo Freire-de-Lima   +12 more
doaj   +1 more source

TLR9-Targeted SiRNA Delivery In Vivo [PDF]

, 2016
The SiRNA strategy is a potent and versatile method for modulating expression of any gene in various species for investigational or therapeutic purposes. Clinical translation of SiRNA-based approaches proved challenging, mainly due to the difficulty of targeted SiRNA delivery into cells of interest and the immunogenic side effects of oligonucleotide ...
Dewan Md Sakib, Hossain, Dayson, Moreira, Qifang, Zhang, Sergey, Nechaev, Piotr, Swiderski, Marcin, Kortylewski   +5 more
openaire   +2 more sources

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Potential Chronotherapeutic Optimization of Antimalarials in Systemic Lupus Erythematosus: Is Toll-Like Receptor 9 Expression Dependent on the Circadian Cycle in Humans?

Frontiers in Immunology, 2018
Toll-like receptor 9 (TLR9) belongs to the group of endosomal receptors of the innate immune system with the ability to recognize hypomethylated CpG sequences from DNA.
Erika Aurora Martínez-García, Erika Aurora Martínez-García, Erika Aurora Martínez-García, Maria Guadalupe Zavala-Cerna, Andrea Verónica Lujano-Benítez, Pedro Ernesto Sánchez-Hernández, Pedro Ernesto Sánchez-Hernández, Beatriz Teresita Martín-Márquez, Beatriz Teresita Martín-Márquez, Flavio Sandoval-García, Flavio Sandoval-García, Flavio Sandoval-García, Mónica Vázquez-Del Mercado, Mónica Vázquez-Del Mercado, Mónica Vázquez-Del Mercado   +14 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

TLR9 signaling requires ligand-induced phosphorylation of two specific tyrosine residues by EGFR and Syk

mBio
Toll-like receptors (TLRs) are transmembrane proteins that recognize microbial components or cellular danger signals and activate intracellular signaling pathways, leading to induction of anti-microbial and inflammatory genes.
Manoj Veleeparambil, Chenyao Wang, Patricia M. Kessler, Pracheta Sengupta, Santanu Das, Ritu Chakravarti, Belinda Willard, Ganes C. Sen, Saurabh Chattopadhyay   +8 more
doaj   +1 more source

The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis [PDF]

International Journal of Inflammation, 2016
Toll-like receptors (TLRs) are key players in the pathogenesis of inflammatory conditions including coronary arterial disease (CAD). They are expressed by a variety of immune cells where they recognize pathogen-associated molecular patterns (PAMPs). TLRs recruit adaptor molecules, including myeloid differentiation primary response protein (MYD88) and ...
Mohsin H. K. Roshan, Amos Tambo, Nikolai P. Pace   +2 more
openaire   +4 more sources

“Nature's Polymer Reimagined: Conventional and Green Routes to Pectin, Its Bioactive Promise and Industrial Applications”

Food Chemistry International, EarlyView.
Pectin, a versatile natural polymer, is extracted through conventional and emerging green extraction methods, offering multifunctional bioactive properties useful in food, pharmaceutical, and environmental applications. ABSTRACT Pectin, a molecular tapestry woven from diverse polysaccharides, holds a pivotal role across food, pharmaceutical, and ...
Afra Anika Rafique, Aunwesha Sahani, Md Morsaline Billah, Kazi Mohammed Didarul Islam   +3 more
wiley   +1 more source

Advances in Immunological Combination Therapy for Colorectal Cancer

iMetaMed, EarlyView.
Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu, Rongbo Wen, Tianshuai Zhang, Fuao Cao, Xiaoming Zhu, Liqiang Hao, Wei Zhang, Guanyu Yu   +7 more
wiley   +1 more source

Development of TLR9 agonists for cancer therapy [PDF]

Journal of Clinical Investigation, 2007
In vertebrates, the TLRs are a family of specialized immune receptors that induce protective immune responses when they detect highly conserved pathogen-expressed molecules. Synthetic agonists for several TLRs, including TLR3, TLR4, TLR7, TLR8, and TLR9, have been or are being developed for the treatment of cancer.
openaire   +2 more sources