Results 71 to 80 of about 65,188 (262)

Protective effect of TLR2/TLR9 agonists on pulmonary Acinetobacter baumannii infection in mice

陆军军医大学学报
Objective To investigate the protective effect of Toll-like receptor (TLR) 2 /TLR9 agonists, Pam2CSK4 (Pam) and CpG ODN (CpG) on mice infected with Acinetobacter baumannii (Ab) in the lungs.
CHENG Hao, YANG Yun, SUN Hongwu
doaj   +1 more source

Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes [PDF]

, 2017
BACKGROUND: Monocytes/macrophages are activated in several autoimmune diseases, including systemic sclerosis (scleroderma; SSc), with increased expression of interferon (IFN)-regulatory genes and inflammatory cytokines, suggesting dysregulation of the ...
Dreyfus, David H., FAGGIONI, Alberto, FARINA, Antonella, Farina, G. Alessandra, Lacconi, Valentina, Lenna, Stefania, MORRONE, Stefania, PERUZZI, Giovanna, QUARTA, SILVIA, ROSATO, Edoardo, Trojanowska, Maria, VESTRI, Anna Rita, York, Michael   +12 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption. [PDF]

, 2019
The role of lymphoid tissue as a potential source of HIV-1 rebound following interruption of antiretroviral therapy (ART) is uncertain. To address this issue, we compared the latent viruses obtained from CD4+ T cells in peripheral blood and lymph nodes ...
Ablanedo-Terrazas, Yuria, Barton, John P, Cohen, Yehuda Z, Damsgaard, Tine, Del Rio Estrada, Perla M, Denton, Paul W, Garcia Noceda, Marco, Lorenzi, Julio CC, Lu, Ching-Lan, Nussenzweig, Michel C, Oliveira, Thiago Y, Pai, Joy A, Reyes-Teran, Gustavo, Søgaard, Ole S, Tolstrup, Martin, Vibholm, Line K   +15 more
core   +1 more source

Toll-Like Receptor 9-Mediated Inflammation Triggers Alveolar Bone Loss in Experimental Murine Periodontitis [PDF]

, 2015
Chronic periodontitis is a local inflammatory disease induced by a dysbiotic microbiota and leading to destruction of the tooth-supporting structures.
Abe, Toshiharu, Crump, Katie E., Hajishengallis, George, Kim, Paul D., Sahingur, Sinem E., Xia-Juan, Xia   +5 more
core   +2 more sources

TLR9-Targeted SiRNA Delivery In Vivo [PDF]

, 2016
The SiRNA strategy is a potent and versatile method for modulating expression of any gene in various species for investigational or therapeutic purposes. Clinical translation of SiRNA-based approaches proved challenging, mainly due to the difficulty of targeted SiRNA delivery into cells of interest and the immunogenic side effects of oligonucleotide ...
Dewan Md Sakib, Hossain, Dayson, Moreira, Qifang, Zhang, Sergey, Nechaev, Piotr, Swiderski, Marcin, Kortylewski   +5 more
openaire   +2 more sources

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

The Role of Dysregulated Neuroinflammatory Molecular Pathways in Parkinson Disease: A Systematic Review [PDF]

Caspian Journal of Neurological Sciences
Background: Parkinson disease (PD) is a prevalent neurodegenerative disorder affecting dopaminergic neurons in the substantia nigra (SN). Neuroinflammation has a vital role in PD pathophysiology.
Mohammadreza Kosari, Afsaneh Asgari Taei, Andis Klegeris, Sevim Soleimani, Arian Tavasol, Kimia Jazi, Kimia Eyvani, Ashkan Bahrami, Zahra Farrokhi, Farnoosh Vosough, Faraz Rahmani Khajeh, Saleh Behzadi, Zohreh Zamani   +12 more
doaj  

Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation [PDF]

, 2014
Funding: JW and NARG thank the Wellcome Trust (080088, 086827, 075470), The Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (097377) and the European Union ALLFUN (FP7/2007 2013, HEALTH-2010-260338) for funding. MGN was supported
Biedermann, Tilo, Brown, Alistair J P, Brown, Gordon D, Gow, Neil A R, Kanneganti, Thirumala-Devi, Köberle, Martin, Lenardon, Megan D, MacCallum, Donna M, Malireddi, R K Subbarao, Netea, Mihai G, Schaller, Martin, Vautier, Simon, Wagener, Jeanette   +12 more
core   +4 more sources

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source