Results 91 to 100 of about 46,527 (261)

TLR9 ligation in pancreatic stellate cells promotes tumorigenesis [PDF]

, 2015
Modulation of Toll-like receptor (TLR) signaling can have protective or protumorigenic effects on oncogenesis depending on the cancer subtype and on specific inflammatory elements within the tumor milieu.
Tuveson, D., Xu, Y., Engle, D. D., Jonnadula, S., Levie, E., Barilla, R., Tippens, D., Pushalkar, S., Daley, D., Nguy, S., Ahn, J., Avanzi, A., Deutsch, M., Miller, G., Hajdu, C., Zambirinis, C. P., Seifert, L., Greco, S. H., Eisenthal, A., Torres-Hernandez, A., Saxena, D.   +20 more
core   +1 more source

Role of defensins in immunothrombosis

Rheumatology &Autoimmunity, EarlyView.
Defensins are important proteins that link the immune system and blood clotting, playing a key role in immunothrombosis. α‐defensins mainly come from neutrophils, while β‐defensins are produced by epithelial cells and platelets. These proteins help form blood clots in several ways: they slow down clot breakdown (fibrinolysis), activate platelets, and ...
Yuebing Wang, Guijuan Guo, Xiangjun Liu, Xiaoyu Chen, Wenqiong Wang, Patapong Towiwat, Ru Li, Chun Li   +7 more
wiley   +1 more source

Regulation of innate liver injury by TLR9

, 2022
Thesis (Master's)--University of Washington, 2022The inflammatory response to hepatocyte death is mediated by TIR-domain containing adapters, which are involved in pattern recognition receptor (PRR) signaling.
Douglass, Alyse
core  

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source

Triad3A-Mediated K48-Linked ubiquitination and degradation of TLR9 impairs mitochondrial bioenergetics and exacerbates diabetic cardiomyopathy

Journal of Advanced Research
Introduction: Targeted protein degradation represents a promising therapeutic approach, while diabetic cardiomyopathy (DCM) arises as a consequence of aberrant insulin secretion and impaired glucose and lipid metabolism in the heart..
Chunyan Kong, Zhen Guo, Fangyuan Liu, Nan Tang, Mingyu Wang, Dan Yang, Chenfei Li, Zheng Yang, Yulan Ma, Pan Wang, Qizhu Tang   +10 more
doaj   +1 more source

Ammonia-Induced Brain Edema Requires Macrophage and T Cell Expression of Toll-Like Receptor 9Summary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aim: Ammonia is central in the pathogenesis of brain edema in acute liver failure (ALF) with infection and systemic inflammation expediting development of intracranial hypertension (ICH).
Godhev Kumar Manakkat Vijay, Changyun Hu, Jian Peng, Irma Garcia-Martinez, Rafaz Hoque, Rejina Mariam Verghis, Yun Ma, Wajahat Zafar Mehal, Debbie Lindsay Shawcross, Li Wen   +9 more
doaj   +1 more source

Development of TLR9 agonists for cancer therapy [PDF]

Journal of Clinical Investigation, 2007
In vertebrates, the TLRs are a family of specialized immune receptors that induce protective immune responses when they detect highly conserved pathogen-expressed molecules. Synthetic agonists for several TLRs, including TLR3, TLR4, TLR7, TLR8, and TLR9, have been or are being developed for the treatment of cancer.
openaire   +2 more sources

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Etude du TLR9 à la membrane plasmique des lymphocytes B : caractérisation des anticorps anti-TLR9 commerciaux

, 2018
Regulatory B cells (Breg) play a key role in regulating the immunological response.This regulatory behaviour can be induced by stimulation of the B cells. Toll-like receptor 9 (TLR9), an innate immune receptor, participate to that induction.
Cumin, Marie
core   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source