Results 81 to 90 of about 65,188 (262)
Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019 Receptorii Toll-like recunosc structurile moleculare legate de agentul patogen a micobacterii și, astfel, joacă un rol important în protecţia organismului faţă de infecţia tuberculoasă.
Alexandru Varzari +5 more
doaj
Toll‐Like Receptor 9 Plays a Pivotal Role in Angiotensin II–Induced Atherosclerosis
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Toll‐like receptor (TLR) 9 recognizes bacterial DNA, activating innate immunity, whereas it also provokes inflammation in response to fragmented DNA released from mammalian cells.
Daiju Fukuda +19 more
doaj +1 more source
Critical role of toll-like receptor 9 in morphine and Mycobacterium tuberculosis-Induced apoptosis in mice. [PDF]
PLoS ONE, 2010 Although it is established that opioid and Mycobacterium tuberculosis are both public health problems, the mechanisms by which they affect lung functions remain elusive.We report here that mice subjected to chronic morphine administration and M ...
Lin Chen +11 more
doaj +1 more source
Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]
, 2018 Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D +13 more
core +1 more source
Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles
Advanced Science, EarlyView.Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu +6 more
wiley +1 more source
Journal of Mazandaran University of Medical Sciences, 2019 Background and purpose: Hepatocellular carcinoma (HCC) is a most common liver malignancy and TLR9 (Toll-like receptor) is essential for CpG DNA-induced immune responses.
Arezou Rezaei +4 more
doaj
Frontiers in Immunology, 2018 Toll-like receptor 9 (TLR9) belongs to the group of endosomal receptors of the innate immune system with the ability to recognize hypomethylated CpG sequences from DNA.
Erika Aurora Martínez-García +14 more
doaj +1 more source
TLR9 agonist protects mice from radiation-induced gastrointestinal syndrome. [PDF]
PLoS ONE, 2012 Radiation-induced gastrointestinal syndrome (RIGS) is due to the clonogenic loss of crypt cells and villi depopulation, resulting in disruption of mucosal barrier, bacterial invasion, inflammation and sepsis.
Subhrajit Saha +7 more
doaj +1 more source
DOCK8 Functions as an Adaptor that Links TLR–MyD88 Signaling to B Cell Activation [PDF]
, 2012 DOCK8 and MyD88 have been implicated in serologic memory. Here we report antibody responses were impaired and \(CD27^+\) memory B cells were severely reduced in DOCK8-deficient patients.
Al-Herz, Waleed +30 more
core +1 more source
Blocking TIR Domain Interactions in TLR9 Signaling [PDF]
The Journal of Immunology, 2018 Abstract Interaction of TLR9 with ligands activates NF-κB, leading to proinflammatory cytokine production. Excessive TLR activation is a pathogenic factor for inflammatory diseases. This study has examined cell-permeating decoy peptides (CPDPs) derived from the TLR9 Toll/IL-1R resistance (TIR) domain. CPDP 9R34, which included AB loop, β-
Artur Javmen +3 more
openaire +2 more sources