Results 21 to 30 of about 38,400 (238)
Frontiers in Molecular Neuroscience, 2022 Toll like receptor 9 (TLR9) is a critical sensor for danger-associated molecular patterns (DAMPs) and a crucial marker of non-sterile/sterile inflammation among all TLRs. However, the significance of TLR9 in inflammatory pain remains unclear.
Yu Chen +11 more
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CHANGES OF INNATE IMMUNITY INDEXES IN SEVERE ASTHMA IN CHILDREN
Медицинская иммунология, 2019 At the present time, the role of innate immunity in pathogenesis of bronchial asthma (BA) is actively studied, in particular, significance of TLRs and cytokines. The study included 42 patients with severe bronchial asthma (from 3 to 12 years old), and 67
L. V. Gankovskaya +9 more
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Drug Design, Development and Therapy, 2021 Qingling Guo,1,2 Haili Qu,3 Hong Zhang,4 Xia Zhong4 1Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, People’s Republic of China; 2Department of Endocrinology, Shandong Provincial ...
Guo Q, Qu H, Zhang H, Zhong X
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Natural killer cell-dependent anti-fibrotic pathway in liver injury via Toll-like receptor-9. [PDF]
PLoS ONE, 2013 The toll-like receptor-9 (TLR9) agonist cytosine phosphate guanine (CpG), activates hepatic stellate cells (HSCs) and mediates fibrosis. We investigated the TLR9 effects on lymphocyte/HSCs interactions.
Lina Abu-Tair +7 more
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The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review
Current Issues in Pharmacy and Medical Sciences, 2020 The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human Epstein-Barr (EBV) and Papillomavirus-(HPV) related cancers.
Dworzanska Anna +1 more
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TLR9−/− and TLR9+/+ mice display similar immune responses to a DNA vaccine [PDF]
Immunology, 2004 SummaryPlasmid DNA continues to attract interest as a potential vaccine‐delivery vehicle. However, the mechanisms whereby immune responses are elicited by plasmids are not fully understood. Although there have been suggestions regarding the importance of CpG motifs in plasmid immunogenicity, the molecular mechanisms by which CpG motifs enhance immune ...
Shawn, Babiuk +6 more
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Drug Design, Development and Therapy, 2021 Qin Li,1,* Jie Ren,2,* Wei Liu,3 Guoqin Jiang,2 Rongkuan Hu1 1GenePharma Co., Ltd., Suzhou, 215125, Jiangsu, People’s Republic of China; 2Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004,
Li Q, Ren J, Liu W, Jiang G, Hu R
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Sensing the hybrid—a novel PAMP for TLR9 [PDF]
The EMBO Journal, 2014 The host immune response is initiated by pattern recognition receptors (PRR) when triggered by specific ligands known as pathogen-associated molecular patterns (PAMP). Toll-like receptor 9 is highly expressed in plasmacytoid dendritic cells and is well described as a PRR for CpG DNA which induce the production of cytokines and type I interferons.
Søren B, Jensen, Søren R, Paludan
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The role of toll-like receptor 9 (TLR9) in Epstein-Barr virus-associated gastric cancer
Current Issues in Pharmacy and Medical Sciences, 2020 Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is the most common malignancy caused by EBV infection. Toll-like receptors (TLRs) as major components of innate immune system are crucial in the development of inflammatory processes and ...
Dworzanska Anna +6 more
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Was Induction of HIV-1 Through TLR9? [PDF]
The Journal of Immunology, 2003 Equils et al. ([1][1]) reported implication of simultaneous activation of Toll-like receptors (TLRs) on HIV replication. When spleen cells from HIV-1 transgenic mice were exposed to agonists of TLR2, TLR4, and TLR9, p24 production was induced.
Sudhir, Agrawal, R Russell, Martin
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