Results 21 to 30 of about 65,188 (262)
TLR9 mediates S. aureus killing inside osteoblasts via induction of oxidative stress [PDF]
, 2016 Background: Staphylococcus aureus is the principle causative pathogen of osteomyelitis and implant-associated bone infections. It is able to invade and to proliferate inside osteoblasts thus avoiding antibiotic therapy and the host immune system ...
Alt, Volker +7 more
core +2 more sources
Natural killer cell-dependent anti-fibrotic pathway in liver injury via Toll-like receptor-9. [PDF]
PLoS ONE, 2013 The toll-like receptor-9 (TLR9) agonist cytosine phosphate guanine (CpG), activates hepatic stellate cells (HSCs) and mediates fibrosis. We investigated the TLR9 effects on lymphocyte/HSCs interactions.
Lina Abu-Tair +7 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Toll-Like Receptor 9 (TLR9) elicits cellular response to nucleic acids derived from pathogens or dead cells. Previous studies have shown that TLR9-driven response may lead to differential impact on the pathogenesis of liver diseases.
Liuyi Hao +5 more
doaj +1 more source
Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]
, 2020 The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia +4 more
core +2 more sources
Репродуктивная эндокринология, 2017 The aim of study. To reveal the peculiarities of mRNA expression of the inflammatory component genes of the immune response in the expected window of the implantation in women with RPL in ART programs. Material and methods.
К. П. Головатюк +4 more
doaj +1 more source
Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle [PDF]
, 2014 Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and ...
Abe +100 more
core +1 more source
Low doses of ionizing radiation induce immune-stimulatory responses in isolated human primary monocytes [PDF]
, 2013 The health effects arising from exposure to low doses of ionizing radiation are of particular concern, mainly due to the increased application of diagnostic and therapeutic X-ray modalities.
Baatout, Sarah +3 more
core +1 more source
Transcription of toll-like receptors 2, 3, 4 and 9, FoxP3 and Th17 cytokines in a susceptible experimental model of canine Leishmania infantum infection [PDF]
, 2015 Canine leishmaniosis (CanL) due to Leishmania infantum is a chronic zoonotic systemic disease resulting from complex interactions between protozoa and the canine immune system.
A Ives +81 more
core +4 more sources
New vistas on TLR9 activation [PDF]
European Journal of Immunology, 2011 AbstractTogether with other reports, evidence published in this issue of the European Journal of Immunology by Avalos and Ploegh (Eur. J. Immunol. 2011. 41: 2820–2827) implies that trafficking of TLR9 from the ER to endolysosomal compartments, which is aided by the transmembrane UNC93B1 ER protein, is followed by proteolytic cleavage of the TLR9 ...
openaire +2 more sources
CHANGES OF INNATE IMMUNITY INDEXES IN SEVERE ASTHMA IN CHILDREN
Медицинская иммунология, 2019 At the present time, the role of innate immunity in pathogenesis of bronchial asthma (BA) is actively studied, in particular, significance of TLRs and cytokines. The study included 42 patients with severe bronchial asthma (from 3 to 12 years old), and 67
L. V. Gankovskaya +9 more
doaj +1 more source