Results 21 to 30 of about 46,527 (261)
Lactate-Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis. [PDF]
Cell ProlifThis study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Guo J +5 more
europepmc +2 more sources
CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo [PDF]
, 2007 Background Bacterial DNA containing motifs of unmethylated CpG dinucleotides (CpG-ODN) initiate an innate immune response mediated by the pattern recognition receptor Toll-like receptor 9 (TLR9).
Schwederski Markus +21 more
core +1 more source
The role of toll-like receptor 9 (TLR9) in Epstein-Barr virus-associated gastric cancer
Current Issues in Pharmacy and Medical Sciences, 2020 Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is the most common malignancy caused by EBV infection. Toll-like receptors (TLRs) as major components of innate immune system are crucial in the development of inflammatory processes and ...
Dworzanska Anna +6 more
doaj +1 more source
Evolutionary Response Patterns of the Rodent <i>TLR</i> Genes to Climatic Factors. [PDF]
Ecol EvolThis study systematically investigates the associations between climatic factors and the evolutionary dynamics of Toll‐like receptor (TLR) genes across 42 rodent species. Our findings demonstrate that temperature‐related climatic variables (Annual Mean Temperature, Mean Diurnal Range, and Max Temperature of Warmest Month) may modulate the evolutionary ...
Zhao C +6 more
europepmc +2 more sources
Drug Design, Development and Therapy, 2021 Qin Li,1,* Jie Ren,2,* Wei Liu,3 Guoqin Jiang,2 Rongkuan Hu1 1GenePharma Co., Ltd., Suzhou, 215125, Jiangsu, People’s Republic of China; 2Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004,
Li Q, Ren J, Liu W, Jiang G, Hu R
doaj
Antitumor activity of a novel TLR9 agonist and cooperativity with targeted agents [PDF]
, 2008 Novel modified Toll-like receptor 9 (TLR9) agonists, termed immune modulatory oligonucleotides (IMOs), exhibit antitumor activity and are currently investigated in cancer patients. Intriguingly, their mechanisms of action on tumor growth and angiogenesis
Garofalo, Sonia
core +1 more source
Репродуктивная эндокринология, 2017 The aim of study. To reveal the peculiarities of mRNA expression of the inflammatory component genes of the immune response in the expected window of the implantation in women with RPL in ART programs. Material and methods.
К. П. Головатюк +4 more
doaj +1 more source
The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review
Current Issues in Pharmacy and Medical Sciences, 2020 The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human Epstein-Barr (EBV) and Papillomavirus-(HPV) related cancers.
Dworzanska Anna +1 more
doaj +1 more source
Polymorphisms and expression of toll-like receptors in autoimmune thyroid diseases
Autoimmunity, 2017 Graves’ disease (GD) and Hashimoto’s disease (HD) are autoimmune thyroid diseases (AITDs). Prognosis of AITDs varies in each patient. Toll-like receptors (TLRs) are pattern-recognition receptors that activate signaling pathways involved in the production
Naoya Inoue +8 more
doaj +1 more source
Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice. [PDF]
PLoS ONE, 2017 Genetic deficiency in TLR9 accelerates pathogenesis in the spontaneous polygenic MRL.Faslpr murine model of systemic lupus erythematosus, despite the absence of anti-nucleosome autoantibodies. However, it could be argued that this result was dependent on
Kevin M Nickerson +3 more
doaj +1 more source