Results 11 to 20 of about 38,400 (238)
Characterization of cooperative PS-oligo activation of human TLR9
Molecular Therapy - Nucleic Acids, 2023 Single-stranded phosphorothioate oligonucleotides (PS-oligos) can activate TLR9, leading to an innate immune response. This can occur with PS-oligos containing unmethylated CpG sites, the canonical motif, or PS-oligos that do not contain those motifs ...
Adam Pollak, Stanley Crooke
exaly +3 more sources
Frontiers in Pharmacology, 2021 Toll-Like Receptor 9 (TLR9) elicits cellular response to nucleic acids derived from pathogens or dead cells. Previous studies have shown that TLR9-driven response may lead to differential impact on the pathogenesis of liver diseases.
Liuyi Hao, Xinguo Sun, Zhanxiang Zhou
exaly +3 more sources
Blocking Toll-like receptor 9 attenuates bleomycin-induced pulmonary injury [PDF]
Journal of Pathology and Translational Medicine, 2022 Background Acute respiratory distress syndrome (ARDS) is one of the most common complications in coronavirus disease 2019 patients suffering from acute lung injury (ALI). In ARDS, marked distortion of pulmonary architecture has been reported.
Badr Alzahrani +5 more
doaj +1 more source
Immunocytochemical characteristic of the endometrial mucosa HIV-infected women [PDF]
Гинекология, 2020 Relevance. Human immunodeficiency virus (HIV) infection is an independent factor in reduced fertility and a risk factor for miscarriage. There are some date an endometrial receptivity of HIV-infected patients has changed that plays an important role in ...
Irina N. Vorobtsova +5 more
doaj +1 more source
The role of Toll-like receptors in chemoradiotherapy-induced gastrointestinal mucositis
口腔疾病防治, 2021 Mucositis is a common gastrointestinal complication in cancer patients undergoing chemoradiotherapy, including oral mucositis and gastrointestinal mucositis, with clinical manifestations of oral ulcers, vomiting, diarrhea and pain that seriously reduce ...
JI Ling +3 more
doaj +1 more source
Mechanisms of TLR9 activation [PDF]
Journal of Endotoxin Research, 2004 Non-methylated CpG-motifs in bacterial or viral DNA are recognized by TLR9 as foreign. The activation of TLR9 by microbial DNA or synthetic oligonucleotides based on these motifs leads to the induction of innate immune responses. We have compared the subcellular localization of fluorescent versions of TLR9 and TLR4 and found that TLR9 is expressed in ...
Eicke, Latz +3 more
openaire +2 more sources
TLR9 gene expression in immune cells of patients with psoriasis
Consilium Medicum, 2022 Background. Psoriasis (skin lesions and psoriatic arthritis PA) is a chronic inflammatory autoimmune disease that can be triggered by excessive activation of endosomal toll-like receptors (TLRs), mainly TLR9. Elevated TLR9 levels are observed in both PA
Svetlana N. Chebysheva +5 more
doaj +1 more source
MAPK signaling regulates the efficacy of chemoimmunotherapy
Molecular & Cellular Oncology, 2022 Resistance to chemoimmunotherapy is a major issue for cancer care. We recently unravelled the role of mitogen-activated protein kinase (MAPK) to limit the antitumor efficacy of such combination.
François Ghiringhelli
doaj +1 more source
Expression of TLR9 and NF-κB in condyloma acuminatum
Pifu-xingbing zhenliaoxue zazhi, 2021 Objective To explore the expression and significance of TLR9 and NF-κB in condyloma acuminatum (CA). Methods The streptavidin-peroxidase (SP) immunohistochemistry method was used to measure the expression of TLR9 and NF-κB in 50 cases of CA and 20 normal
Guangwen YIN +4 more
doaj +1 more source
Cell-Specific TLR9 Trafficking in Primary APCs of Transgenic TLR9-GFP Mice [PDF]
The Journal of Immunology, 2013 Abstract Recognition of nucleic acids by TLR9 requires its trafficking from the endoplasmic reticulum to endolysosomal compartments and its subsequent proteolytic processing. Both processes depend on interactions of TLR9 with the polytopic endoplasmic reticulum–resident protein UNC93B1.
Avalos, Ana M. +8 more
openaire +3 more sources