Results 11 to 20 of about 46,527 (261)
New vistas on TLR9 activation [PDF]
European Journal of Immunology, 2011 AbstractTogether with other reports, evidence published in this issue of the European Journal of Immunology by Avalos and Ploegh (Eur. J. Immunol. 2011. 41: 2820–2827) implies that trafficking of TLR9 from the ER to endolysosomal compartments, which is aided by the transmembrane UNC93B1 ER protein, is followed by proteolytic cleavage of the TLR9 ...
Wagner, H, Hermann Wagner
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TLR9 agonists induced cell death in Burkitt's lymphoma cells is variable and influenced by TLR9 polymorphism [PDF]
Cell Death & Disease, 2012 Toll-like receptor 9 (TLR9) triggering is a promising novel strategy to combat cancer as it induces innate and adaptive immunity responses. B-cell lymphoma is unique in this context as tumor cells express TLR9 and may harbor latent Epstein-Barr virus (EBV), a gamma-herpesvirus with remarkable oncogenic potential when latent.
Noack, J +8 more
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TLR9 agonist protects mice from radiation-induced gastrointestinal syndrome. [PDF]
PLoS ONE, 2012 Radiation-induced gastrointestinal syndrome (RIGS) is due to the clonogenic loss of crypt cells and villi depopulation, resulting in disruption of mucosal barrier, bacterial invasion, inflammation and sepsis.
Subhrajit Saha +7 more
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TLR9 Trafficking and Signaling [PDF]
, 2019 Toll-like Receptor 9 (TLR9) is an endosomal receptor found highly expressed in B cells and plasmacytoid dendritic cells (pDCs). It is activated by unmethylated CpG DNA and synthetic CpG oligodeoxyribonucleotides (ODNs) to produce pro-inflammatory cytokines (TNFα, IL-12) and type I interferons (IFNs).
Cemalovic, Ena
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CHANGES OF INNATE IMMUNITY INDEXES IN SEVERE ASTHMA IN CHILDREN
Медицинская иммунология, 2019 At the present time, the role of innate immunity in pathogenesis of bronchial asthma (BA) is actively studied, in particular, significance of TLRs and cytokines. The study included 42 patients with severe bronchial asthma (from 3 to 12 years old), and 67
L. V. Gankovskaya +9 more
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Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection [PDF]
, 2013 Persistent production of type I interferon (IFN) by activated plasmacytoid dendritic cells (pDC) is a leading model to explain chronic immune activation in human immunodeficiency virus (HIV) infection but direct evidence for this is lacking.
Simon C Watkins +39 more
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Drug Design, Development and Therapy, 2021 Qingling Guo,1,2 Haili Qu,3 Hong Zhang,4 Xia Zhong4 1Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, People’s Republic of China; 2Department of Endocrinology, Shandong Provincial ...
Guo Q, Qu H, Zhang H, Zhong X
doaj
Frontiers in Pharmacology, 2021 Toll-Like Receptor 9 (TLR9) elicits cellular response to nucleic acids derived from pathogens or dead cells. Previous studies have shown that TLR9-driven response may lead to differential impact on the pathogenesis of liver diseases.
Liuyi Hao +5 more
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, 2005 Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
Anders, Hans-Joachim, H-J Anders
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Natural killer cell-dependent anti-fibrotic pathway in liver injury via Toll-like receptor-9. [PDF]
PLoS ONE, 2013 The toll-like receptor-9 (TLR9) agonist cytosine phosphate guanine (CpG), activates hepatic stellate cells (HSCs) and mediates fibrosis. We investigated the TLR9 effects on lymphocyte/HSCs interactions.
Lina Abu-Tair +7 more
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