Results 51 to 60 of about 272,563 (343)

TLR4 rs1927914 polymorphism contributes to serum TLR4 levels in patients with aortic aneurysm

Experimental and Molecular Pathology, 2021
Toll-like receptor 4 (TLR4) is a crucial regulator of inflammatory reactions and vascular remodeling. Elevated TLR4 expression has been proved to be correlated with an increased risk of aortic aneurysm (AA). This study aimed to explore the influence of TLR4 gene polymorphisms on TLR4 expression levels and its probable functional significance in AA ...
Tan, Li, Jingjing, Jing, Nannan, Dong, Xiaozheng, Liu, Chunyan, Ma, Jun, Yang   +5 more
openaire   +2 more sources

TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K/AKT pathway after spinal cord injury

Cell Death and Disease, 2020
Neuroinflammation plays a crucial role in the secondary phase of spinal cord injury (SCI), and is initiated following the activation of toll-like receptor 4 (TLR4). However, the downstream mechanism remains unknown.
Shun Xu, Jin Wang, Jianyuan Jiang, Jian Song, Wei Zhu, Fan Zhang, Minghao Shao, Haocheng Xu, Xiaosheng Ma, F. Lyu   +9 more
semanticscholar   +1 more source

Bacterial TLR4 and NOD2 signaling linked to reduced mitochondrial energy function in active inflammatory bowel disease

Gut Microbes, 2020
Inflammatory bowel disease (IBD) has been linked to active signaling with bacterial components and reduced mitochondrial ATP production; however, synergism between both of these disease characteristics remains unclear.
Emmanuelle Ruiz, Harrison M. Penrose, Sandra Heller, Hani Nakhoul, Melody Baddoo, Erik F. Flemington, Emad Kandil, Suzana D. Savkovic   +7 more
doaj   +1 more source

TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis

Vaccines, 2017
Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate immune response and its activation by bacterial endotoxin is responsible for chronic and acute inflammatory disorders that are becoming more and more frequent in ...
N. Kuzmich, Konstantin V. Sivak, V. Chubarev, Yury B. Porozov, T. N. Savateeva-Lyubimova, F. Peri   +5 more
semanticscholar   +1 more source

STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

Nature Communications, 2020
Detection of microbial components such as lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) on macrophages induces a robust pro-inflammatory response that is dependent on metabolic reprogramming. These innate metabolic changes have been compared to
Jesse J. Balic, Hassan Albargy, Kevin Luu, Francis J Kirby, W. Jayasekara, Finbar Mansell, Daniel J. Garama, N. Baschuk, D. Nardo, Cynthia Louis, Fiarchra Humphries, K. Fitzgerald, E. Latz, D. Gough, A. Mansell   +14 more
semanticscholar   +1 more source

Tuo-Min-Ding-Chuan Decoction Alleviates Airway Inflammations in the Allergic Asthmatic Mice Model by Regulating TLR4-NLRP3 Pathway-Mediated Pyroptosis: A Network Pharmacology and Experimental Verification Study

Drug Design, Development and Therapy, 2023
Mingsheng Lyu,1,2 Jingbo Qin,3 Shuaiyang Huang,2 Dongmei Shao,4 Guirui Huang,2 Fan Yang,5,6 Xuefeng Gong,7 Shiyu Zhang,2 Zhijie Zhang,2 Ji Wang,6 Hongsheng Cui2 1Center of Respiratory Disease, Dongzhimen Hospital, Beijing University of Chinese Medicine ...
Lyu M, Qin J, Huang S, Shao D, Huang G, Yang F, Gong X, Zhang S, Zhang Z, Wang J, Cui H   +10 more
doaj  

Acupuncture Attenuates Inflammation in Microglia of Vascular Dementia Rats by Inhibiting miR-93-Mediated TLR4/MyD88/NF-κB Signaling Pathway

Oxidative Medicine and Cellular Longevity, 2020
Background It is widely accepted that inflammation may contribute to cognitive impairment in patients with vascular dementia (VD). Our prior clinical researches have reported that acupuncture can alleviate cognitive function in VD, but the underlying ...
Lu Wang, Jing-Wen Yang, Li-Ting Lin, Jin Huang, Xue‐Rui Wang, Xin-Tong Su, Yan Cao, M. Fisher, Cun-Zhi Liu   +8 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Anti-inflammatory potential of black cumin seed oil and its nanoemulsion formulation against lipopolysaccharide-induced liver injury in mice

Asian Pacific Journal of Tropical Biomedicine
Objective: To evaluate the anti-inflammatory effect of black cumin seed oil (BCSO) and its nanoemulsion on lipopolysaccharide (LPS)-induced liver injury in mice. Methods: LPS-induced acute liver injury mouse model was used to evaluate the effects of BCSO
Hesham Haffez, Rehab Hosni, Shady A. Swidan, Hatem K. Amin   +3 more
doaj   +1 more source

The correlation between serum resistin and toll-like receptor-4 with insulin resistance in hypertensive subjects with or without type 2 diabetes mellitus

Baghdad Journal of Biochemistry and Applied Biological Sciences, 2021
Background: The most chronic disease prevalence in the Iraqi population are type-2 diabetes mellitus (T2DM) and hypertension (HT). One of the important causes of these chronic diseases is obesity.
Mustafa K. Al-Taie, Rayah S. Baban, Mouayed B. Hamed   +2 more
doaj   +1 more source