Renal Failure, 2020 Objective Nephrotoxicity is the main side effect of cyclosporine A and finding an effective combating method is urgent. The present study investigates the improving effect of erythropoietin (EPO) on cyclosporine A induce renal injury in rats and further ...
Bin Liu, Ping Tan
doaj +1 more source
LPS/TLR4 Pathways in Breast Cancer: Insights into Cell Signalling
, 2022 Background: Cancer cells are usually recognized as foreign particles by the immune cells. Mounting evidence suggest an important link between toll-like receptors (TLRs) and carcinogenesis. This review article focused on the role of TLRs, especially TLR4,
Afroz, R +5 more
core +1 more source
TLR4/MyD88/PI3K interactions regulate TLR4 signaling
Journal of Leukocyte Biology, 2009 AbstractTLRs activate immune responses by sensing microbial structures such as bacterial LPS, viral RNA, and endogenous “danger” molecules released by damaged host cells. MyD88 is an adapter protein that mediates signal transduction for most TLRs and leads to activation of NF-κB and MAPKs and production of proinflammatory cytokines.
Michelle H W, Laird +6 more
openaire +3 more sources
Inflammatory response modulation by epinephrine and norepinephrine
RUDN Journal of Medicine, 2023 Relevance. Inflammation is a defense response of an organism to a pathogen. It appears in order to maintain homeostasis and is regulated by the immune, nervous, and endocrine systems.
Svetlana V. Guryanova +2 more
doaj +1 more source
Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer-Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy. [PDF]
Adv Sci (Weinh)A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Guo X +10 more
europepmc +2 more sources
The effect of a high-intensity interval training with Portulaca oleracea supplementation on Irisin and TLR4 in the liver tissue of rats with non-alcoholic fatty liver disease [PDF]
مجله علوم پزشکی فیض (پیوسته), 2023 Background: Lifestyle modification through dietary interventions and exercise training is still one of the most effective ways to treat non-alcoholic fatty liver disease.
Majid Farah Nia +3 more
doaj
Fibronectin III 13-14 Domains Induce Joint Damage via Toll-Like Receptor 4 Activation and Synergize with Interleukin-1 and Tumour Necrosis Factor [PDF]
, 2011 Cartilage loss is a feature of chronic arthritis. It results from degradation of the extracellular matrix which is composed predominantly of aggrecan and type II collagen.
Saralili Dipa Robertson +6 more
core +1 more source
Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62 [PDF]
, 2012 ES-62 is an immunomodulatory phosphorylcholine (PC)-containing glycoprotein secreted by the rodent filarial nematode Acanthocheilonema viteae. Previously, the use of knockout mice has revealed the effects of ES-62 on macrophages and dendritic cells to be
Allen, Janet +3 more
core +4 more sources
Postulates for validating TLR4 agonists [PDF]
European Journal of Immunology, 2015 TLRs play a central role in the innate immune response, recognizing a variety of molecular structures characteristic of pathogens. Although TLR4, together with its co‐receptor myeloid differentiation‐2 (MD‐2), recognize bacterial LPS and therefore Gram‐negative bacterial infections, it also plays a key role in many other pathophysiological processes ...
Mateja, Manček-Keber, Roman, Jerala
openaire +2 more sources
, 2021 We hypothesized that blood transfusion could induce platelet-mediated innate immune reactions caused by the interaction between TLR4 and damage-associated molecular patterns (DAMPs).
huang, G (via Mendeley Data)
core +4 more sources