Results 31 to 40 of about 172,294 (303)
Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62 [PDF]
, 2012 ES-62 is an immunomodulatory phosphorylcholine (PC)-containing glycoprotein secreted by the rodent filarial nematode Acanthocheilonema viteae. Previously, the use of knockout mice has revealed the effects of ES-62 on macrophages and dendritic cells to be
Allen, Janet +3 more
core +4 more sources
Postulates for validating TLR4 agonists [PDF]
European Journal of Immunology, 2015 TLRs play a central role in the innate immune response, recognizing a variety of molecular structures characteristic of pathogens. Although TLR4, together with its co‐receptor myeloid differentiation‐2 (MD‐2), recognize bacterial LPS and therefore Gram‐negative bacterial infections, it also plays a key role in many other pathophysiological processes ...
Mateja, Manček-Keber, Roman, Jerala
openaire +2 more sources
, 2021 We hypothesized that blood transfusion could induce platelet-mediated innate immune reactions caused by the interaction between TLR4 and damage-associated molecular patterns (DAMPs).
huang, G (via Mendeley Data)
core +4 more sources
TLR4 rs1927914 polymorphism contributes to serum TLR4 levels in patients with aortic aneurysm
Experimental and Molecular Pathology, 2021 Toll-like receptor 4 (TLR4) is a crucial regulator of inflammatory reactions and vascular remodeling. Elevated TLR4 expression has been proved to be correlated with an increased risk of aortic aneurysm (AA). This study aimed to explore the influence of TLR4 gene polymorphisms on TLR4 expression levels and its probable functional significance in AA ...
Tan, Li +5 more
openaire +2 more sources
Delayed Resolution of Acute Inflammation in Ulcerative Colitis Is Associated with Elevated Cytokine Release Downstream of TLR4 [PDF]
, 2010 Background: Ulcerative colitis (UC) is widely viewed as a leukocyte-mediated disorder. Although strong evidence implicates an exuberant response to microbial components in its pathogenesis, no intrinsic immune defect has been identified and the ...
Bu'Hussain Hayee +17 more
core +2 more sources
Ivermectin decreases inflammation and imiquimod–induced psoriasis-like skin lesions in rat via targeting TLR4 / p65 NF-κB [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Psoriasis is a chronic skin disease that usually manifests as white and silver spots on the skin. Because of its anti-inflammatory properties, we investigated the effects of ivermectin (IVM) on imiquimod (IMQ)-induced psoriasis in rats ...
Tayebeh Noori +2 more
doaj +1 more source
Gut Microbes, 2020 Inflammatory bowel disease (IBD) has been linked to active signaling with bacterial components and reduced mitochondrial ATP production; however, synergism between both of these disease characteristics remains unclear.
Emmanuelle Ruiz +7 more
doaj +1 more source
Association between TLR4 and PTEN Involved in LPS-TLR4 Signaling Response
BioMed Research International, 2016 In this study, we explored the potential mechanisms of how PTEN regulating LPS induced TLR4 signaling pathway. The initial findings from ELISA demonstrate that PTEN influences TNF-αsecretion by its lipid phosphatase activity. Subsequently, western blot, immunoprecipitation assay, and immunofluorescence were performed to explore the activation process ...
Huahua Yin +8 more
openaire +3 more sources
TLR4-dependent stimulation of IFN-β by ProTα variants.
, 2016 (A) IFN-β, (B) IL-6, and (C) TNF-α expression was measured by RT-qPCR on cDNAs from wild type and TLR4-/- mouse bone marrow-derived macrophages treated with 200 ng/ml of different ProTα variants for 2 h. Though at lower levels, TNF-α remains inducible by
Judith Aberg (2839373) +4 more
core +1 more source
Unravelling the anti-inflammatory mechanisms of dietary fatty acids [PDF]
, 2009 Polyunsaturated fatty acids (PUFA) have been shown to modulate immune responses and have therapeutic effects in inflammatory disorders. The specific mechanisms of their actions have yet to be defined.
Dowling, Jennifer K.
core +2 more sources