Results 21 to 30 of about 170,484 (302)

Interaction of Opioids with TLR4—Mechanisms and Ramifications [PDF]

Cancers, 2021
The innate immune receptor toll-like receptor 4 (TLR4) is known as a sensor for the gram-negative bacterial cell wall component lipopolysaccharide (LPS). TLR4 activation leads to a strong pro-inflammatory response in macrophages; however, it is also recognised to play a key role in cancer.
Mai Mahmoud Gabr, Iqira Saeed, Jared A. Miles, Benjamin P. Ross, Paul Nicholas Shaw, Markus W. Hollmann, Marie-Odile Parat   +6 more
openaire   +5 more sources

The Defensive Action of LYRM03 on LPS-Induced Acute Lung Injury by NF-κB/TLR4/NLRP3 Signals

Journal of Investigative Surgery, 2021
The aim of the current investigation was to study the role of 3-amino-2-hydroxy-4-phenyl-valyl-isoleucine (LYRM03) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and investigate its potential pathogenesis.
Bin Wang, Jiaoyue Wang, Daopeng Lu, Na Qi, Qin Liu   +4 more
doaj   +1 more source

Paroxetine effect on expression of TLR2 and TLR4 genes in PBMCs of mentally normal individuals [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2021
Background: Paroxetine is one of the well-known antidepressants. Recent studies have focused on paroxetine’s probable immuno-modulatory effects, since findings have indicated inflammation’s role in the pathophysiology of depression.
Fatemeh Ganjalishahi, Anahid Hemmatpur, Mahdi Dehghan manshadi, Hossein Hadi nedoushan, Alireza Karimollah   +4 more
doaj   +1 more source

Biallelic TLR4 deficiency in humans

Journal of Allergy and Clinical Immunology, 2023
Toll-like receptors (TLRs) mediate functions for host defense and inflammatory responses. TLR4 recognizes LPS, a component of gram-negative bacteria as well as host-derived endogenous ligands such as S100A8 and S100A9 proteins.We sought to report phenotype and cellular function of individuals with complete TLR4 deficiency.We performed genome sequencing
Melania Capitani, Ahmad A. Al-Shaibi, Sumeet Pandey, Lisa Gartner, Henry Taylor, Satanay Z. Hubrack, Nourhen Agrebi, Muneera Jassim Al-Mohannadi, Saad Al Kaabi, Thomas Vogl, Johannes Roth, Daniel Kotlarz, Christoph Klein, Adrian K. Charles, Vinayan Vijayakumar, Mohammed Yousuf Karim, Bruce George, Simon P. Travis, Mamoun Elawad, Bernice Lo, Holm H. Uhlig   +20 more
openaire   +3 more sources

Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages [PDF]

, 2009
Background Toll-like receptors (TLRs) are present on monocytes and alveolar macrophages that form the first line of defense against inhaled particles.
Esmaeil Mortaz, Nijkamp, Frans P, Caldenhoven Eric, Caldenhoven, Eric, Kraneveld, Aletta D, Gert Folkerts, Sarir Hadi, Folkerts Gert, Nijkamp Frans P, Khalil Karimi, Kraneveld Aletta D, Karimi Khalil, Sarir, Hadi, Mortaz Esmaeil, Karimi, Khalil, Rahman Irfan, Folkerts, Gert, Frans P Nijkamp, Rahman, Irfan, Irfan Rahman, Eric Caldenhoven, Aletta D Kraneveld, Mortaz, Esmaeil, Hadi Sarir   +23 more
core   +1 more source

Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients [PDF]

, 2011
Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs)
Carsten Schwenke, Matthias Schott, Koch, Alexander, Stefan R Bornstein, Ralf R Schumann, Schott, Matthias, Lutz Hamann, Hamann, Lutz, Bornstein, Stefan R., Schwenke, Carsten, Alexander Koch, Muhammed Kurt, Zacharowski, Kai, Kai Zacharowski, Olaf Boehm, Schumann, Ralf R., Grotemeyer, Dirk, Kurt, Muhammed, Boehm, Olaf, Dirk Grotemeyer   +19 more
core   +1 more source

Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release : an observational study in three cohorts [PDF]

, 2010
Introduction: It has been proposed that individual genetic variation contributes to the course of severe infections and sepsis. Recent studies of single nucleotide polymorphisms (SNPs) within the endotoxin receptor and its signaling system showed an ...
Oh, Djin Ye, Koch, Alexander, David A Schwartz, van der Meer, Jos W. M., Latz, E., Eicke Latz, Djin-Ye Oh, Schumann, Ralf R, Schumann, R.R., Chryssanthi Skalioti, van der Meer, Jos WM, Jos WM van der Meer, Kumpf, Oliver, Skalioti, C., Eva Lorenz, van der Meer, Jos W.M., van der Meer, J.W., Schwartz, David A, Schlag, Peter M., Netea, M.G., Giamarellos-Bourboulis, Evangelos, Bart-Jan Kullberg, Kai Zacharowski, Mouktaroudi, Maria, Mouktaroudi, M., Latz, Eicke, Lorenz, Eva, Netea, Mihai G, Kumpf, O., Schlag, P.M., Kullberg, B.J., Schlag, Peter M, Peter M Schlag, Hamann, L., Lorenz, E., Kullberg, Bart Jan, Lutz Hamann, Ferwerda, B., Maria Mouktaroudi, Christina Routsi, Alexander Koch, Zacharowski, Kai, Oliver Kumpf, Schumann, Ralf R., Routsi, C., Evangelos J Giamarellos-Bourboulis, Bart Ferwerda, Mihai G Netea, Routsi, Christina, Koch, A., Schwartz, David A., Skalioti, Chryssanthi, Ralf R Schumann, Giamarellos-Bourboulis, E.J., Meer, J.W.M. van der, Kullberg, Bart-Jan, Hamann, Lutz, Netea, Mihai G., Giamarellos-Bourboulis, Evangelos J., Oh, D.Y., Schwartz, D.A., Oh, Djin-Ye, Zacharowski, K., Ferwerda, Bart, Giamarellos-Bourboulis, Evangelos J   +64 more
core   +2 more sources

Decursin negatively regulates LPS-induced upregulation of the TLR4 and JNK signaling stimulated by the expression of PRP4 in vitro

Animal Cells and Systems, 2020
The current investigation was carried out to analyze the correlation of bacterial lipopolysaccharide (LPS) and pre-mRNA processing factor 4B (PRP4) in inducing inflammatory response and cell actin cytoskeleton rearrangement in macrophages (Raw 264.7) and
Muhammad Bilal Ahmed, Salman Ul Islam, Young Sup Lee   +2 more
doaj   +1 more source

Effects of three types of fresh Rehmannia glutinosa improve lipopolysaccharide-induced acute kidney injury in sepsis through the estrogen receptor pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): To explore the effects and mechanism of three types of fresh Rehmannia glutinosa, namely Beijing No. 3 (BJ3H), Huaizhong No. 1 (HZ1H), and Taisheng (TS) on lipopolysaccharide (LPS)-induced acute kidney injury in the sepsis (S-AKI) mice ...
Meng Liu, Mengnan Zeng, Pengli Guo, Yuhan Zhang, Xiaofeng Yang, Jufang Jia, Qinqin Zhang, Beibei Zhang, Bing Cao, Ru Wang, Xiaoke Zheng, Weisheng Feng   +11 more
doaj   +1 more source

Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state [PDF]

, 2001
Background: Macrophages sense microorganisms through activation of members of the Toll-like receptor family, which initiate signals linked to transcription of many inflammation associated genes.
Aderem, A, Underhill David M, Ozinsky, A O, Underhill, D. M., Ozinsky, A.O., Sweet Matthew J, Hume, D A, Liew Foo Y, Sweet, M J, Underhill, D M, Liew, F Y, Liew, F.Y., Aderem, A., Sweet, M. J., Hume, D. A., Hume David A, Ozinsky Adrian O, Aderem Alan   +17 more
core   +1 more source