Results 71 to 80 of about 170,484 (302)

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

A Review: The Significance of Toll-Like Receptors 2 and 4, and NF-κB Signaling in Endothelial Cells during Atherosclerosis

Frontiers in Bioscience-Landmark
Atherosclerosis (AS) is a chronic inflammatory vascular disease that begins with endothelial activation followed by a series of inflammatory responses, plaque formation, and finally rupture.
Baoxin Yan, Xiaoxian Yu, Xianzhen Cai, Xiaojun Huang, Bin Xie, Danchun Lian, Jinhao Chen, Weiwen Li, Ying Lin, Junjun Ye, Jilin Li   +10 more
doaj   +1 more source

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

RNase L Is Involved in Liposaccharide-Induced Lung Inflammation

Viruses, 2020
RNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade ...
Ruhan Wei, Guanmin Chen, Naseh Algehainy, Chun Zeng, Chunfang Liu, Hongli Liu, Wendy Liu, Dennis Stacey, Aimin Zhou   +8 more
doaj   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

The development of metabolic endotoxemia is dependent on the type of sweetener and the presence of saturated fat in the diet

Gut Microbes, 2020
Fat and sweeteners contribute to obesity. However, it is unknown whether specific bacteria are selectively modified by different caloric and noncaloric sweeteners with or without a high-fat diet (HFD).
Mónica Sánchez-Tapia, Aaron W. Miller, Omar Granados-Portillo, Armando R. Tovar, Nimbe Torres   +4 more
doaj   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Sialylation of campylobacter jejuni lipo-oligosaccharides: impact on phagocytosis and cytokine production in mice [PDF]

, 2012
<p>Background: Guillain-Barré syndrome (GBS) is a post-infectious polyradiculoneuropathy, frequently associated with antecedent Campylobacter jejuni (C. jejuni) infection. The presence of sialic acid on C.
Alistair S. Easton (176369), Astrid Heikema (176373), Alistair S Easton, Jim Guthrie, Donachie Anne M., Easton, A.S. (Alistair), Anne M. Donachie (176370), Boon, Louis, Goodyear, C.S. (Carl), Ruth Huizinga, Jacobs, Bart C., Hugh J Willison, Easton, Alistair S., van Rijs, Wouter, Louis Boon, Easton, AS, Samsom, JN, Jacobs Bart C., Willison, H.J. (Hugh), Heikema, Astrid, Willison, HJ, Louis Boon (87167), Jacobs, B.C. (Bart), Carl S Goodyear, Bart C. Jacobs (139863), Astrid Heikema, Guthrie, J. (Jim), Bart C Jacobs, Heikema, A.P. (Astrid), Boon, L. (Louis), Willison, Hugh J., Willison Hugh J., Donachie, AM, Guthrie, J, Carl S. Goodyear (176375), Heikema Astrid, van Rijs, W, Guthrie, Jim, Huizinga Ruth, Rijs, Wouter, Donachie, A.M. (Anne), Goodyear Carl S., Easton, Alistair, Samsom, J.N. (Janneke), Huizinga, Ruth, Anne M Donachie, Samsom, Janneke, Samsom Janneke N., Jacobs, B.C., Janneke N. Samsom (176374), Guthrie Jim, Boon, L, Goodyear, CS, Hugh J. Willison (139850), van Rijs Wouter, Huizinga, R, Huizinga, R. (Ruth), Boon Louis, Easton Alistair S., Wouter van Rijs, Boon, L (Louis), Wouter van Rijs (139839), Samsom, Janneke N., Rijs, W. (Wouter) van, Donachie, Anne M., Janneke N Samsom, Heikema, A, Ruth Huizinga (176367), Jacobs, BC, Goodyear, Carl S., Jim Guthrie (176371)   +70 more
core   +4 more sources

Binding free energies of TLR4, vaccine, and TLR4-vaccine complex.

, 2023
Binding free energies of TLR4, vaccine, and TLR4-vaccine complex.
Shahin Nazarian (9192158), Sajjad Ahmad (768814), Hamidreza Pazoki-Toroudi (10879906), Mahdi Ghatreh Samani (15852860), Elham Raeisi (15852857), Samira Sanami (13192454), Muhammad Tahir ul Qamar (9269536), Shahram Tahmasebian (14233182), Maryam Fazeli (3171162)   +8 more
core   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source