Results 31 to 40 of about 44,760 (265)

Role of Low Frequency Repetitive Trans Cranial Magnetic Stimulation in Drug Resistant Epilepsy Clinical, Laboratory and Neurophysiology Study [PDF]

International Journal of Medical Arts
Background: Drug-resistant epilepsy [DRE] poses significant challenges in management, affecting a huge number of epileptic patients despite the availability of antiepileptic medications.
Asmaa Mohamed Abd Elwaged, Hoda M Masoud, Rasha El-bialy Elsharkawy, Sarah Younes Abdelaziz   +3 more
doaj   +1 more source

Long non-coding RNA LINC00704 promotes cell proliferation, migration, and invasion in papillary thyroid carcinoma via miR-204-5p/HMGB1 axis

Open Life Sciences, 2020
Papillary thyroid carcinoma (PTC) is a common malignancy worldwide. LncRNA LINC00704 (mitotically associated long non-coding RNA) was reported as a crucial regulator in PTC.
Lin Yihui, Jiang Jianjia
doaj   +1 more source

Peripheral HMGB1-induced hyperalgesia in mice: Redox state-dependent distinct roles of RAGE and TLR4

Journal of Pharmacological Sciences, 2016
Nuclear HMGB1 that contains 3 cysteine residues is acetylated and secreted to the extracellular space, promoting inflammation via multiple molecules such as RAGE and TLR4.
Daichi Yamasoba, Maho Tsubota, Risa Domoto, Fumiko Sekiguchi, Hiroyuki Nishikawa, Keyue Liu, Masahiro Nishibori, Hiroyasu Ishikura, Tetsushi Yamamoto, Atsushi Taga, Atsufumi Kawabata   +10 more
doaj   +1 more source

HMGB1 and injury amplification

Oncotarget, 2015
While apoptotic cell death is believed to be mostly non-reactive and hence a component of development and tissue homeostasis, other forms of cell death such as necrosis and necroptosis are considered reactive, resulting in strong inflammatory responses.
Peter, Huebener, Celine, Hernandez, Robert F, Schwabe   +2 more
openaire   +2 more sources

HMGB1 Mediates Microglia-Astrocyte/Neuron Crosstalk and Pyroptosis by the TLR4/NF-κB Pathway in Multiple Sclerosis

Frontiers in Bioscience-Landmark
Background: Multiple sclerosis (MS) is characterized as a chronic inflammatory autoimmune disorder affecting the central nervous system (CNS).
Yang Feng, Liang Wang, Zhuofeng Mao, Weiping Wang   +3 more
doaj   +1 more source

HMGB1-mediated apoptosis and autophagy in ischemic heart diseases

Vascular Biology, 2019
Acute myocardial infarction (MI) and its consequences are the most common and lethal heart syndromes worldwide and represent a significant health problem.
Eleonora Foglio, Laura Pellegrini, Antonia Germani, Matteo Antonio Russo, Federica Limana   +4 more
doaj   +1 more source

Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation [PDF]

Molecular Medicine, 2019
Extracellular high mobility group box 1 protein  (HMGB1) serves a central role in inflammation as a transporter protein, which binds other immune-activating molecules that are endocytosed via the receptor for advanced glycation end-products (RAGE). These pro-inflammatory complexes are targeted to the endolysosomal compartment, where HMGB1 permeabilizes
Huan Yang, Hui Liu, Qiong Zeng, Gavin H. Imperato, Meghan E. Addorisio, Jianhua Li, Mingzhu He, Kai Fan Cheng, Yousef Al-Abed, Helena E. Harris, Sangeeta S. Chavan, Ulf Andersson, Kevin J. Tracey   +12 more
openaire   +3 more sources

High‐mobility group box 1 emerges as a therapeutic target for asthma

Immunity, Inflammation and Disease, 2023
High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair.
Qianni Yang, Min Li, Yunjiao Hou, Huilin He, Shibo Sun   +4 more
doaj   +1 more source

Necroptosis of Lung Epithelial Cells Triggered by Ricin Toxin and Bystander Inflammation

Cellular Physiology and Biochemistry, 2023
Background/Aims: The ribosome-inactivating proteins include the biothreat agent, ricin toxin (RT). When inhaled, RT causes near complete destruction of the lung epithelium coincident with a proinflammatory response that includes TNF family cytokines ...
LaRocca
doaj   +1 more source

HMGB1 as a representative DAMP and anti-HMGB1 antibody therapy

Folia Pharmacologica Japonica, 2018
High mobility group box-1 (HMGB1), a representative damage-associated molecular patterns (DAMPs), has been reported to be involved in many inflammatory diseases. To validate HMGB1 as a target molecule of inflammatory diseases and to examine the effects of inhibition of HMGB1 on the diseases, we raised anti-HMGB1 monoclonal antibody (mAb) neutralizing ...
openaire   +3 more sources