Results 51 to 60 of about 51,717 (306)
Peripheral HMGB1-induced hyperalgesia in mice: Redox state-dependent distinct roles of RAGE and TLR4
Journal of Pharmacological Sciences, 2016 Nuclear HMGB1 that contains 3 cysteine residues is acetylated and secreted to the extracellular space, promoting inflammation via multiple molecules such as RAGE and TLR4.
Daichi Yamasoba +10 more
doaj +1 more source
HMGB1 and injury amplification
Oncotarget, 2015 While apoptotic cell death is believed to be mostly non-reactive and hence a component of development and tissue homeostasis, other forms of cell death such as necrosis and necroptosis are considered reactive, resulting in strong inflammatory responses.
Peter, Huebener +2 more
openaire +2 more sources
Frontiers in Bioscience-LandmarkBackground: Multiple sclerosis (MS) is characterized as a chronic inflammatory autoimmune disorder affecting the central nervous system (CNS).
Yang Feng +3 more
doaj +1 more source
HMGB1-mediated apoptosis and autophagy in ischemic heart diseases
Vascular Biology, 2019 Acute myocardial infarction (MI) and its consequences are the most common and lethal heart syndromes worldwide and represent a significant health problem.
Eleonora Foglio +4 more
doaj +1 more source
High‐mobility group box 1 emerges as a therapeutic target for asthma
Immunity, Inflammation and Disease, 2023 High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair.
Qianni Yang +4 more
doaj +1 more source
Necroptosis of Lung Epithelial Cells Triggered by Ricin Toxin and Bystander Inflammation
Cellular Physiology and Biochemistry, 2023 Background/Aims: The ribosome-inactivating proteins include the biothreat agent, ricin toxin (RT). When inhaled, RT causes near complete destruction of the lung epithelium coincident with a proinflammatory response that includes TNF family cytokines ...
LaRocca
doaj +1 more source
, 2011 Copyright information:Taken from "Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis"http://arthritis-research.com/content/9/2/R35Arthritis Research & Therapy 2007;9(2):R35-R35.Published ...
Riikka Söderling (32046) +6 more
core +1 more source
MiRNA-129-5p Targeting HMGB1 Inhibits Proliferation and Migration of Osteosarcoma Cells
Zhongliu Fangzhi Yanjiu, 2022 Objective To investigate the effects of miR-129-5p on the proliferation and migration of osteosarcoma cells and the regulation of HMGB1 gene. Methods The expression of miR-129-5p and HMGB1 in osteosarcoma cell line MG-63, Saos-2 and osteoblast hFOB1.19 ...
ZHANG Huaibin +4 more
doaj +1 more source
High-mobility group box protein 1 (HMGB1) expression in collagen-induced arthritis
, 2011 The presence of cells expressing HMGB1 in the invading pannus of collagen-induced arthritis is shown. In this experiment, the section was stained for HMGB1 using affinity-purified polyclonal rabbit anti-HMGB1 antibodies (BD Pharmingen, San Diego, CA, USA)
David S Pisetsky (23495) +2 more
core +1 more source
HMGB1 as a representative DAMP and anti-HMGB1 antibody therapy
Folia Pharmacologica Japonica, 2018 High mobility group box-1 (HMGB1), a representative damage-associated molecular patterns (DAMPs), has been reported to be involved in many inflammatory diseases. To validate HMGB1 as a target molecule of inflammatory diseases and to examine the effects of inhibition of HMGB1 on the diseases, we raised anti-HMGB1 monoclonal antibody (mAb) neutralizing ...
openaire +3 more sources