Results 51 to 60 of about 56,183 (304)
Necroptosis of Lung Epithelial Cells Triggered by Ricin Toxin and Bystander Inflammation
Cellular Physiology and Biochemistry, 2023 Background/Aims: The ribosome-inactivating proteins include the biothreat agent, ricin toxin (RT). When inhaled, RT causes near complete destruction of the lung epithelium coincident with a proinflammatory response that includes TNF family cytokines ...
LaRocca
doaj +1 more source
HMGB1 and injury amplification
Oncotarget, 2015 While apoptotic cell death is believed to be mostly non-reactive and hence a component of development and tissue homeostasis, other forms of cell death such as necrosis and necroptosis are considered reactive, resulting in strong inflammatory responses.
Peter, Huebener +2 more
openaire +2 more sources
HMGB1-RAGE Axis Makes No Contribution to Cardiac Remodeling Induced by Pressure-Overload. [PDF]
, 2016 High-mobility group box1 (HMGB1) exerts effects on inflammation by binding to receptor for advanced glycation end products (RAGE) or Toll-like receptor 4.
Hairuo Lin (3161859) +25 more
core +1 more source
MiRNA-129-5p Targeting HMGB1 Inhibits Proliferation and Migration of Osteosarcoma Cells
Zhongliu Fangzhi Yanjiu, 2022 Objective To investigate the effects of miR-129-5p on the proliferation and migration of osteosarcoma cells and the regulation of HMGB1 gene. Methods The expression of miR-129-5p and HMGB1 in osteosarcoma cell line MG-63, Saos-2 and osteoblast hFOB1.19 ...
ZHANG Huaibin +4 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The roles of HMGB1 in liver injury
, 2022 The liver, an organ with a vital role in the organism, can become inflamed for various reasons and activate many intracellular and extracellular signalling pathways.
Memi, Gülsün
core
Targeting HMGB1 in the treatment of sepsis [PDF]
Expert Opinion on Therapeutic Targets, 2014 Sepsis refers to the host's deleterious and non-resolving systemic inflammatory response to microbial infections and represents the leading cause of death in the intensive care unit. The pathogenesis of sepsis is complex, but partly mediated by a newly identified alarmin molecule, the high mobility group box 1 (HMGB1).Here we review the evidence that ...
Haichao, Wang +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Cancer Management and Research, 2020 Chuanping Yuan, Ling Yang Department of Oncology, The Xinyu People’s Hospital, Xinyu, Jiangxi 338000, People’s Republic of ChinaCorrespondence: Ling YangDepartment of Oncology, The Xinyu People’s Hospital, No.369 Xinxin North Road ...
Yuan C, Yang L
doaj
HMGB1 as a representative DAMP and anti-HMGB1 antibody therapy
Folia Pharmacologica Japonica, 2018 High mobility group box-1 (HMGB1), a representative damage-associated molecular patterns (DAMPs), has been reported to be involved in many inflammatory diseases. To validate HMGB1 as a target molecule of inflammatory diseases and to examine the effects of inhibition of HMGB1 on the diseases, we raised anti-HMGB1 monoclonal antibody (mAb) neutralizing ...
openaire +3 more sources